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Autologous HIV-specific T cell therapy targeting conserved epitopes is well-tolerated in six adults with HIV: an open-label, single-arm phase 1 study

While anti-retroviral therapy (ART) helps contain HIV, whether adoptive T cell therapy further improve the prognosis is unclear. Here the authors conduct an open-label, single-arm phase 1 study to assess the safety (primary outcome) and characteristic (secondary outcome) of autologous, HIV-specific T cell therapy to find it safe to warrant further efficacy assessment.

Danielle K. Sohai
Michael D. Keller
Catherine M. Bollard
ResearchOpen Access15 May 2025
Nature Communications

Volume: 16, P: 1-15
Onset of strong Iceland-Scotland overflow water 3.6 million years ago

This study examines the history of North Atlantic deep-water masses, as recorded in marine sediments. Major lithological changes and increased rate of deposition reveal that stronger deep-ocean circulation initiated 3.6 million years ago.

Matthias Sinnesael
Boris-Theofanis Karatsolis
Ross E. Parnell-Turner
ResearchOpen Access09 May 2025
Nature Communications

Volume: 16, P: 1-10
Amazon forests capture high levels of atmospheric mercury pollution from artisanal gold mining

The Peruvian Amazon is facing the highest known input of mercury pollution of any ecosystem globally. Intact forests located near artisanal gold mining are particularly at risk from this toxin.

Jacqueline R. Gerson
Natalie Szponar
Emily S. Bernhardt
ResearchOpen Access28 Jan 2022
Nature Communications

Volume: 13, P: 1-10
Developing a standardized framework for evaluating health apps using natural language processing

Julian Herpertz
Bridget Dwyer
John Torous
ResearchOpen Access06 Apr 2025
Scientific Reports

Volume: 15, P: 1-11
Addressing preferred specimen orientation in single-particle cryo-EM through tilting

The preferred specimen orientation problem limits accuracy and resolution in structure determination by cryo-EM. Collecting data at defined sample tilts yielded near-atomic-resolution structures for the influenza hemagglutinin trimer and ribosomal biogenesis intermediates.

Yong Zi Tan
Philip R Baldwin
Dmitry Lyumkis
Research03 Jul 2017
Nature Methods

Volume: 14, P: 793-796

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Autologous HIV-specific T cell therapy targeting conserved epitopes is well-tolerated in six adults with HIV: an open-label, single-arm phase 1 study

Onset of strong Iceland-Scotland overflow water 3.6 million years ago

Amazon forests capture high levels of atmospheric mercury pollution from artisanal gold mining

Developing a standardized framework for evaluating health apps using natural language processing

Addressing preferred specimen orientation in single-particle cryo-EM through tilting

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