Conplastic mice that share the same nuclear genome but have different mitochondrial DNA were analysed throughout their life — the mitochondrial genome affects many aspects of physiology and results in differences in median lifespan; the authors propose that the interplay of mitochondrial and nuclear genomes may be an important factor influencing this phenomenon.
- Ana Latorre-Pellicer
- Raquel Moreno-Loshuertos
- José Antonio Enríquez
