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Evaluating long-term immunogenicity and safety, this study shows that fractional and standard dose boosting with Pfizer and AstraZeneca vaccines following CoronaVac or AstraZeneca priming produces adequate immune responses, informing COVID-19 booster vaccination policy.

Using data from the CoVPN 3008 study, the authors show that the neutralizing antibody correlate of risk holds in people living with HIV. However, the nAb correlate was weaker and shorter-lived in a vaccine-immunity versus hybrid-immunity population.

In this study, the authors report that post-vaccination neutralizing and binding antibody levels in the ENSEMBLE trial associate with Ad26.COV2.S vaccine efficacy (VE) against severe-critical COVID-19, with substantial VE even at unquantifiable neutralizing antibody titer.

China’s housing vacancy rate is estimated to have exceeded 30% since 2021. New research shows that targeted vacancy reduction, renovation, and demolition limits could cut China’s urban housing construction emissions by over 43% by 2060, aiding efforts toward meeting carbon neutrality goals.

Authors have previously reported on the efficacy and safety of the recombinant spike protein nanoparticle vaccine, NVX-CoV2373, in healthy adults. In this work, they assess anti-spike binding IgG, anti-RBD binding IgG and neutralising antibody titer as correlates of risk and protection against COVID-19.

Gold-standard evidence for correlates of protection is provided by analysis of a randomized phase 3 trial of Ad26.COV2.S for protection against moderate to severe-critical COVID-19 disease.

The rapid deployment of low-carbon measures is urgently needed to reduce cement emissions as cement CO₂ emissions from developing countries will almost deplete the remaining cement emissions budget within climate targets.

A large study in the United Kingdom shows that virus-specific antibody levels associated with at least 67% protection against SARS-CoV-2 Delta variant infection last longer after two doses of BNT162b2 vaccine than after two doses of ChAdOx1 vaccine in previously uninfected individuals.

Big-data empowered traffic signal control in China can reduce vehicle trip times, creating potential reduction of 31.73 million tonnes (Mt) of CO2 emissions annually and US$31.8 billion benefits per year.

Waning immunity and the emergence of the SARS-CoV-2 Omicron lineage led to reduced vaccine effectiveness and required vaccine updates. Here, the authors assess how different priming regimens affect the immunogenicity of BA.1 and BA.5 bivalent boosters.

The combined impacts of climate change and deforestation are estimated to reduce Amazon tree species richness by up to 58% by 2050, whilst deforestation alone may cause 19–36%, and climate change alone 31–37%.

The impact of prior infection on the immune response to COVID-19 vaccination has not been fully characterised. Here, the authors use data from ~100,000 adults in the UK and find that a single vaccine dose in those with prior infection produces a comparable or stronger response to two doses in those without infection.

The duration and strength of protection against SARS-CoV-2 infection resulting from a booster vaccine dose or breakthrough infection are not well understood. This study uses data from the UK COVID-19 Infection Survey to investigate correlates of protection against Omicron BA.4/5 infection and assess antibody responses to booster vaccination and breakthrough infections.

Aviation contributes to climate change and ways to reduce its emissions are widely debated. Here, the authors assess the effects of technology improvements and the use of sustainable aviation fuels and find that even when these are considered aviation is unlikely to meet emissions goals in line with the Paris Agreement.

Aerosol pollution from shipping contributes to cooling but also leads to premature mortality and morbidity. Here the authors combine emission inventories, atmospheric models and health risk functions to show how cleaner marine fuels will reduce premature deaths and childhood asthma but results in larger warming.

Current trends imply that we will transgress most of the planetary boundaries by 2050; however, ambitious, urgent and universal action to ameliorate climate change and increase resource efficiency can effectively reduce the degree of transgression.

Despite a rise in COVID-19 cases among children, there is limited understanding of the antibody responses mounted, compared to in adults. In this work, authors compare seroconversion rates and antibody responses in unvaccinated Australian children across the three SARS-CoV-2 waves (Wuhan, Delta and Omicron).

Nonlinear transitions in permafrost carbon feedback and surface albedo feedback have largely been excluded from climate policy studies. Here the authors modelled the dynamics of the two nonlinear feedbacks and the associated uncertainty, and found an important contribution to warming which leads to additional economic losses from climate change.

PM_2.5 pollution partially counteracts vegetation greening trends by delaying green-up dates and reducing photosynthetic activity. This study shows that the negative feedback between PM_2.5 pollution and terrestrial carbon uptake introduces unforeseen uncertainty in China’s carbon neutrality goals.

Emerging SARS-CoV-2 variants raise concerns on immune evasion. Here, the authors evaluate the neutralization efficiency of COVID-19 mRNA vaccinee sera against representative viruses of 13 WHO-designated SARS-CoV-2 variants of concern/interest.

Sensitive methods for antibody detection tend to be expensive and slow. Here, the authors report a magnetic particle spectroscopy method named COMPASS, as a rapid and low-cost technique which is comparable to ELISA in terms of sensitivity but with a measurement times of seconds.

Here, the authors report results from a Phase 1 trial with an AS03-adjuvanted, plant-based virus-like particle displaying the spike protein of the ancestral SARS-CoV-2. Six months post-second dose, they observe good neutralizing antibody titers and T cell responses to ancestral virus and variants of concern in participants.

Vast areas of the Amazon forest have been lost to agriculture in recent decades. This study assesses the potential of intensification—increasing yields on a given area—to produce more soybean in Brazil without further Amazon forest loss and to reduce existing CO₂ emissions.

Estimates of infection rates from the UK COVID-19 Infection Survey may have been biased by the characteristics of people who chose to take part. Here, the authors show that the survey population had unusually high vaccination rates and adjust infection estimates taking this into account.

Safeguarding existing forests is an important ecological concern but constrains the expansion of farmland to feed the growing world population. Here the authors analyse the option space for future changes in agriculture and diets compatible with a no-deforestation goal.

Defined levels of SARS-CoV-2-specific binding and neutralizing antibodies elicited by the COVID-19 vaccine ChAdOx1 nCoV-19 are identified as correlates of protection against symptomatic infection.

Prior infection or exposure to SARS-CoV-2 may influence immunogenicity and effectiveness of subsequent vaccination to new strains of virus. Here the authors show that immunogenicity of a BA.4/5 mRNA vaccine differed in recipients depending on whether they had been exposed to or infected with an earlier strain of virus.

Understanding how oil supply-side policies affect extraction, emissions and communities is important for the design of decarbonization pathways. Here the authors take a modelling approach to characterizing 2020–2045 decarbonization scenarios from various policies applied to California’s oil extraction.

Enhanced rock weathering is competitive with other carbon sequestration strategies in terms of land, energy and water use with its overall sustainability dependent on that of the energy system supplying it, according to a process-based life cycle assessment.

The SARS-CoV-2 Omicron variant is associated with high rates of vaccine breakthrough infections, but the immunological basis for this is not well characterised. Here, the authors show that increased anti-Spike IgG antibody levels are associated with a reduced risk of infection with the Delta variant, but not with Omicron.

The authors characterize immune response in Omicron-infected vaccinated individuals and observe an immune enhancement. While increases in neutralizing antibodies and spike T cells are stronger in previously naïve individuals, mucosal antibodies and non-spike responses increase regardless of infection history.

Future hydrogen economies need massive amounts of low-carbon hydrogen. Here, we show that mismatches between economic production and supply locations, water scarcity, and the need for renewable power and materials might limit large-scale hydrogen production.

Substituting fossil fuels with bioenergy from forests, as well as thinning forests to reduce wildfire emissions, has been proposed as a means of cutting carbon dioxide emissions. A study based on inventory data for US West Coast forests now challenges this proposal, and finds that it could lead to 2–14% higher emissions than current management practices over the next 20 years.

There is a growing need to find cost-effective options for greenhouse gas abatement. In this study, spatially disaggregated marginal abatement cost curves are developed to facilitate economic appraisal of tropical reforestation.

Enhancing nitrogen use efficiency can effectively reduce soil nitrogen losses from fertilizer use in the production of maize and wheat, according to a global analysis of field measurement data on crop-specific soil nitrogen losses.

Representing both socio-economic and climate uncertainties in a complex human-Earth system model provides probability distributions of human and Earth system outcomes that can help inform a risk-based decision-making process.

Development of vaccines remains challenging because viral antigens can be unstable or aggregate. Here, authors present ancestral sequence reconstruction as a method to generate stable and soluble antigens using exclusively available sequence information.

Current SARS-CoV-2 vaccines require several injections for optimal immune protection. Here, the authors report an intranasal live-attenuated vaccine that induces long-term immunity following a single dose and protects from SARS-CoV-2 wildtype and variants in non-human primate and small animal models.

Restoration of abandoned farmlands has the potential to improve ecosystem functions and benefits. Using a multidisciplinary approach, Knoke et al. show that ecological and economic indicators favour either afforestation or intense pasturing of these abandoned areas in the tropical Andes.

Relative economic benefits of achieving temperature targets have not properly accounted for damages at higher temperatures. Here the authors integrate dynamic cost-benefit analysis with a damage-cost curve and show that the Paris Climate Agreement constitutes the economically optimal policy pathway for the future.

SARS-CoV-2 evolution poses a risk to vaccine and antiviral drug efficacy. Here, Gagne et al. report the development of a variant-agnostic protein, RBD-62, with enhanced ACE2 binding obtained through in vitro evolution and show that RBD-62 inhalation protects nonhuman primates against SARS-CoV-2 Delta challenge.

In this work, the authors performed a single-cell genotyping and transcriptomics analysis, revealing cell-type-specific and nonautonomous effects of mTOR pathway mutations in mosaic focal cortical dysplasia.

Online shopping deliveries are booming, but the environmental cost is not always accounted. Here, the authors examine the impact of delivery services in China from 2007 to 2018 and find that Greenhouse gas emissions surged from 0.3 Mt in 2007 to 13.7 Mt of CO₂-equivalent in 2018, they predict that emissions could reach 75 MtCO₂e by 2035 if no mitigation measures are adopted.