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Chemotherapeutic drugs sensitize pre-B ALL cells for CD95- and cytotoxic T-lymphocyte-mediated apoptosis

C Posovszky
C Friesen
K-M Debatin
Research10 Mar 1999
Leukemia

Volume: 13, P: 400-409
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Ruth Loos and colleagues report results of a large genome-wide association study for body mass index. They identify 18 new loci associated with this trait, some of which map near key hypothalamic regulators of energy balance.

Elizabeth K Speliotes
Cristen J Willer
Ruth J F Loos
Research10 Oct 2010
Nature Genetics

Volume: 42, P: 937-948
Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

Adult forms of inflammatory bowel disease (IBD) are of a polygenic nature, but paediatric and very early onset (VEO) IBD also occur as monogenic forms. Here, using whole exome sequencing, the authors explore both the monogenic and polygenic contribution to VEO-IBD and characterize a rare somatic mosaic VEO-IBD patient.

Eva Gonçalves Serra
Tobias Schwerd
Carl A. Anderson
ResearchOpen Access21 Feb 2020
Nature Communications

Volume: 11, P: 1-15
Author Correction: Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

Eva Gonçalves Serra
Tobias Schwerd
Carl A. Anderson
Amendments and CorrectionsOpen Access22 Jun 2022
Nature Communications

Volume: 13, P: 1
The promise of new anti-obesity therapies arising from knowledge of genetic obesity traits

Rare monogenic obesity is caused by pathogenic variants in single genes, while common obesity mostly has a polygenic basis. This Review discusses genetic obesity traits, the emergence of novel pharmacological treatment options that target the central melanocortin pathway and future innovative therapies.

Anke Hinney
Antje Körner
Pamela Fischer-Posovszky
Reviews28 Jul 2022
Nature Reviews Endocrinology

Volume: 18, P: 623-637
Diagnostic delay in children with inflammatory bowel disease in the German-Austrian patient registry CEDATA-GPGE 2014–2018

Maren Leiz
Melanie Knorr
Neeltje van den Berg
ResearchOpen Access07 Dec 2022
Scientific Reports

Volume: 12, P: 1-9
NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease

T Schwerd
R V Bryant
H H Uhlig
ResearchOpen Access01 Nov 2017
Mucosal Immunology

Volume: 11, P: 562-574

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Chemotherapeutic drugs sensitize pre-B ALL cells for CD95- and cytotoxic T-lymphocyte-mediated apoptosis

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

Author Correction: Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

The promise of new anti-obesity therapies arising from knowledge of genetic obesity traits

Diagnostic delay in children with inflammatory bowel disease in the German-Austrian patient registry CEDATA-GPGE 2014–2018

NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease

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