Cells with multiple centrosomes, as are often observed in cancer, can still divide successfully because the centrosomes cluster to form a single spindle pole body. Drosopoulos et al.show that degradation of the kinesin Eg5 by APC/C-CDH1 is required for centrosome clustering.
- Konstantinos Drosopoulos
- Chan Tang
- Spiros Linardopoulos
