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Showing 1–10 of 10 results
Advanced filters: Author: C. Erec Stebbins Clear advanced filters

  • The co-crystal structure of VSGsur with the trypanocidal compound suramin directly links the binding of the drug to the resistance phenotype displayed by strains of Trypanosoma brucei expressing VSGsur. Therefore, VSGs can have a function beyond that of antigenic variation.

    • Johan Zeelen
    • Monique van Straaten
    • C. Erec Stebbins
    Research
    Nature Microbiology
    Volume: 6, P: 392-400

  • Helicobacter pylori is a strong risk factor for stomach cancer. The CagA effector protein is translocated into host cells by a type IV secretion system and is a key virulence factor. Its effects are mediated in part through the host polarity kinase PAR1b/MARK2, which CagA binds and inhibits. The crystal structure of a complex between CagA peptide and MARK2 reveals that the CagA peptide mimics targets of this kinase family.

    • Dragana Nes̆ić
    • Marshall C Miller
    • C Erec Stebbins
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 130-132

  • Analyses of the toxin produced by Salmonella Typhi bacteria reveal an unusual assembly of toxin subunits, and show that most symptoms of typhoid fever can be linked to one subunit's DNA-damaging activity. See Letter p.350

    • C. Erec Stebbins
    News & Views
    Nature
    Volume: 499, P: 293

  • Trypanosoma brucei parasites switch their variant surface glycoprotein (VSG) coats to escape immune recognition. The crystal structure of VSG3 reveals that additional modifications, such as O-glycosylation, further expand antigenic variation and potentiate immune evasion.

    • Jason Pinger
    • Dragana Nešić
    • C. Erec Stebbins
    Research
    Nature Microbiology
    Volume: 3, P: 932-938

  • In bacteria, type III secretion systems (T3SS) allow the direct transport of protein across membranes, and related elements of a sorting platform facilitate hierarchical secretion of protein substrates. Here, the authors illustrate the mechanism of selective assembly of the T3SS sorting platforms in injectisome and flagellar systems.

    • Ryan Q. Notti
    • Shibani Bhattacharya
    • C. Erec Stebbins
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-11

  • Structural biology is making significant contributions toward an understanding of molecular constituents and mechanisms underlying human diseases at an atomic resolution, as discussed at the international Murnau Conference on Structural Biology of Disease Mechanisms held in September 2007 in Murnau, Germany.

    • K Ulrich Wendt
    • Manfred S Weiss
    • Dirk W Heinz
    News & Views
    Nature Structural & Molecular Biology
    Volume: 15, P: 117-120