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Advanced filters: Author: Caiyi Pang Clear advanced filters

  • Prime editing enables precise and efficient genome editing, but its efficacy is hindered by pegRNA’s 3’ extension. Here the authors develop a mismatched pegRNA (mpegRNA) strategy to reduce complementarity and secondary structure formation and can increase prime editing efficiency and reduce indels.

    • Jidong Fei
    • Dongdong Zhao
    • Xueli Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10