Nature Search

Human oligodendrocyte progenitor cells mediate synapse elimination through TAM receptor activation

Oligodendrocyte progenitor cells (OPCs) contribute to developmental synapse elimination in animal models. Here, the authors use a human brain organoid model to demonstrate that that uptake of synapses in a subset of human OPCs depends on growth arrest-specific gene 6 (GAS6)-AXL signaling.

Asimenia Gkogka
Susmita Malwade
Carl M. Sellgren
ResearchOpen Access05 Dec 2025
Nature Communications

Volume: 16, P: 1-13
Discoveries in complex biosystems

Carl Persson
Correspondence01 Oct 1997
Nature Biotechnology

Volume: 15, P: 927
Subcellular localization as a driver of protein function

Proteins can localize to multiple cellular compartments and some exhibit distinct functions depending on their location. This Review discusses the mechanisms of protein localization, the control of specialized protein functions through subcellular localization, and how mislocalization is involved in cancer, neurodegeneration and autoimmunity.

Alina Sigaeva
Charlotte Hutchings
Emma Lundberg
Reviews18 Feb 2026
Nature Reviews Molecular Cell Biology

P: 1-18
Viral DNA and a viral peptide can act as cofactors of adenovirus virion proteinase activity

Walter F. Mangel
William J. McGrath
Carl W. Anderson
Research01 Jan 1993
Nature

Volume: 361, P: 274-275
A cornucopia of drug discovery?

Carl Persson
Correspondence01 Jan 1996
Nature Medicine

Volume: 2, P: 5-6
Adaptations for stealth in the wing-like flippers of a large ichthyosaur

Analysis of a fossilized front flipper of the Jurassic ichthyosaur Temnodontosaurus that preserves details of soft tissue indicates the presence of a serrated trailing edge that would have reduced noise generated while swimming, enabling stealth hunting and hiding from predators.

Johan Lindgren
Dean R. Lomax
Dan-Eric Nilsson
ResearchOpen Access16 Jul 2025
Nature

Volume: 644, P: 976-983
Primary lysis of eosinophils as a major mode of activation of eosinophils in human diseased tissues

Carl Persson
Lena Uller
Correspondence25 Nov 2013
Nature Reviews Immunology

Volume: 13, P: 902
A genetic-epigenetic interplay at 1q21.1 locus underlies CHD1L-mediated vulnerability to primary progressive multiple sclerosis

This study identifies distinct genetic-epigenetictranscriptional interplay at the 1q21.1 locus in relation to neuronal deficits in primary progressive multiple sclerosis (PPMS).

Majid Pahlevan Kakhki
Antonino Giordano
Maja Jagodic
ResearchOpen Access30 Jul 2024
Nature Communications

Volume: 15, P: 1-17
‘Bedside’ observations challenge aspects of the ‘epithelial barrier hypothesis’

Correspondence regarding the Review ‘Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?'

Carl Persson
Correspondence02 Nov 2021
Nature Reviews Immunology

Volume: 21, P: 829
Genetic variation in the clonal bryophyte Hylocomium splendens at hierarchical geographical scales in Scandinavia

Nils Cronberg
Ulf Molau
Mats Sonesson
Research01 Mar 1997
Heredity

Volume: 78, P: 293-301
The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location

Single-cell RNA-seq and ATAC-seq, combined with spatial transcriptomics, identify age- and location-related cellular dynamics of diffuse midline gliomas, such as variable oligodendrocyte precursor-like tumor stem cell populations and increased mesenchymal states with age.

Ilon Liu
Li Jiang
Mariella G. Filbin
ResearchOpen Access05 Dec 2022
Nature Genetics

Volume: 54, P: 1881-1894
Prognostic genome and transcriptome signatures in colorectal cancers

A large integrated genome and transcriptome analysis of colorectal cancer identifies prognostic mutations and expression subtypes.

Luís Nunes
Fuqiang Li
Tobias Sjöblom
ResearchOpen Access07 Aug 2024
Nature

Volume: 633, P: 137-146
Cerebrospinal fluid concentration of complement component 4A is increased in first episode schizophrenia

Schizophrenia risk has been associated with the complement component 4 (C4) genes. Here the authors show that C4A is elevated in individuals with schizophrenia.

Jessica Gracias
Funda Orhan
Carl M. Sellgren
ResearchOpen Access03 Nov 2022
Nature Communications

Volume: 13, P: 1-13
Beta-adrenoceptor drugs and progression to Parkinson’s disease milestones in a large pooled incident cohort

Ruwani S. Wijeyekoon
Marta Camacho
Caroline H. Williams-Gray
ResearchOpen Access03 Jul 2025
npj Parkinson's Disease

Volume: 11, P: 1-10
Clinical research, or classical clinical research?

Carl Persson
Correspondence01 Jul 1999
Nature Medicine

Volume: 5, P: 714-715
A low-eccentricity migration pathway for a 13-h-period Earth analogue in a four-planet system

TOI-500 hosts at least four planets, the innermost of which is an Earth-sized ultra-short-period body with a density similar to Earth. The architecture of the TOI-500 system can be explained by a slow, secular, low-eccentricity migration scenario.

Luisa Maria Serrano
Davide Gandolfi
Carl Ziegler
Research28 Apr 2022
Nature Astronomy

Volume: 6, P: 736-750
Clonidine prevents radiation-induced cell death in human brain organoids

Martin Lundberg
Samudyata
Carl M. Sellgren
ResearchOpen Access31 Oct 2025
Scientific Reports

Volume: 15, P: 1-10
Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

The tau protein is theorized to spread transneuronally in Alzheimers disease, though this theory remains unproven in humans. Our simulations of epidemic-like protein spreading across human brain networks support this theory, and suggest the spreading dynamics are modified by β-amyloid

Jacob W. Vogel
Yasser Iturria-Medina
Per Wollmer
ResearchOpen Access26 May 2020
Nature Communications

Volume: 11, P: 1-15
Associations between lifestyle factors and levels of per- and polyfluoroalkyl substances (PFASs), phthalates and parabens in follicular fluid in women undergoing fertility treatment

Ida Hallberg
Richelle D. Björvang
Pauliina Damdimopoulou
ResearchOpen Access22 Jul 2023
Journal of Exposure Science & Environmental Epidemiology

Volume: 33, P: 699-709
A safe operating space for humanity

Identifying and quantifying planetary boundaries that must not be transgressed could help prevent human activities from causing unacceptable environmental change, argue Johan Rockström and colleagues.

Johan Rockström
Will Steffen
Jonathan A. Foley
Special Features23 Sept 2009
Nature

Volume: 461, P: 472-475
A triple protostar system formed via fragmentation of a gravitationally unstable disk

Observations of the triple protostar system L1448 IRS3B support the hypothesis that companion stars can form because of gravitational instability in a protostellar disk.

John J. Tobin
Kaitlin M. Kratter
Laura M. Pérez
Research26 Oct 2016
Nature

Volume: 538, P: 483-486
Cardiovascular protein profiling in patients with first-episode psychosis

Anna Malmqvist
Feride Eren
Sophie Erhardt
ResearchOpen Access14 Jun 2025
Schizophrenia

Volume: 11, P: 1-10
A Short Polypeptide Marker Sequence Useful for Recombinant Protein Identification and Purification

Thomas P. Hopp
Kathryn S. Prickett
Paul J. Conlon
Research01 Oct 1988
Bio/Technology

Volume: 6, P: 1204-1210
Shaping a resilient future in response to COVID-19

The concept of resilience, once meaning the ability to ‘bounce back’ to the status quo, now refers to the capacity to live and develop with change. A mismatch between the latest science of resilience and the talk of resilience recovery after COVID-19 requires resilience thinking to be aligned with sustainable development.

Johan Rockström
Albert V. Norström
Deon Nel
Reviews11 May 2023
Nature Sustainability

Volume: 6, P: 897-907
Transnational corporations and the challenge of biosphere stewardship

Transnational corporations control large proportions of the industries and commodities that directly and indirectly impact the environment. Here, the authors discuss the problems, but also potential benefits, of such consolidation for sustainability.

Carl Folke
Henrik Österblom
Aart de Zeeuw
Reviews16 Sept 2019
Nature Ecology & Evolution

Volume: 3, P: 1396-1403
Cerebrospinal fluid proteomic study of two bipolar disorder cohorts

Anniella Isgren
Andreas Göteson
Mikael Landén
ResearchOpen Access19 Aug 2022
Molecular Psychiatry

Volume: 27, P: 4568-4574
Assessment of transmitral and left atrial appendage flow rate from cardiac 4D-CT

Bäck et al. describe a motion tracking algorithm to measure the flow rate through the mitral valve (MV) and the left atrial appendage (LAA) from 4D-CT data. The developed algorithm provided accurate tracking of dynamic cardiac geometries resulting in similar flow rates at the MV and LAA to those measured by 4D flow MRI.

Sophia Bäck
Lilian Henriksson
Tino Ebbers
ResearchOpen Access11 Feb 2023
Communications Medicine

Volume: 3, P: 1-9
Scientific mobilization of keystone actors for biosphere stewardship

Henrik Österblom
Carl Folke
Jane Lubchenco
ResearchOpen Access04 Mar 2022
Scientific Reports

Volume: 12, P: 1-17
Improvement in indices of cellular protection after psychological treatment for social anxiety disorder

Kristoffer N. T. Månsson
Daniel Lindqvist
Tomas Furmark
ResearchOpen Access19 Dec 2019
Translational Psychiatry

Volume: 9, P: 1-10
Regulation of fungal decomposition at single-cell level

Michiel Op De Beeck
Carl Troein
Anders Tunlid
ResearchOpen Access02 Jan 2020
The ISME Journal

Volume: 14, P: 896-905
The soil organic matter decomposition mechanisms in ectomycorrhizal fungi are tuned for liberating soil organic nitrogen

César Nicolás
Tomas Martin-Bertelsen
Anders Tunlid
ResearchOpen Access11 Dec 2018
The ISME Journal

Volume: 13, P: 977-988
Chaperonin Assisted Phage Display of Antibody Fragments on Filamentous Bacteriophages

Eskil Söderfind
Ann Catrin Simonsson Lagerkvist
Carl A. K. Borrebaeck
Research01 Apr 1993
Bio/Technology

Volume: 11, P: 503-507
Author Correction: Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

Jacob W. Vogel
Yasser Iturria-Medina
Per Wollmer
Amendments and CorrectionsOpen Access05 Aug 2021
Nature Communications

Volume: 12, P: 1
Neurofilaments as biomarkers in neurological disorders — towards clinical application

Neurofilaments have been validated as specific body fluid biomarkers of neuro-axonal injury. In this Review, Khalil and colleagues provide an update on the structure and function of neurofilaments, analytical approaches and challenges in different clinical contexts, and progress towards clinical application of neurofilaments as a biomarker in various neurological disorders.

Michael Khalil
Charlotte E. Teunissen
Jens Kuhle
Reviews12 Apr 2024
Nature Reviews Neurology

Volume: 20, P: 269-287
A randomized placebo-controlled PET study of ketamine´s effect on serotonin_1B receptor binding in patients with SSRI-resistant depression

Mikael Tiger
Emma R. Veldman
Johan Lundberg
ResearchOpen Access01 Jun 2020
Translational Psychiatry

Volume: 10, P: 1-8
Neurodevelopmental disorders—high-resolution rethinking of disease modeling

Konstantin Khodosevich
Carl M. Sellgren
ReviewsOpen Access25 Nov 2022
Molecular Psychiatry

Volume: 28, P: 34-43

Search

Human oligodendrocyte progenitor cells mediate synapse elimination through TAM receptor activation

Discoveries in complex biosystems

Subcellular localization as a driver of protein function

Viral DNA and a viral peptide can act as cofactors of adenovirus virion proteinase activity

A cornucopia of drug discovery?

Adaptations for stealth in the wing-like flippers of a large ichthyosaur

Primary lysis of eosinophils as a major mode of activation of eosinophils in human diseased tissues

A genetic-epigenetic interplay at 1q21.1 locus underlies CHD1L-mediated vulnerability to primary progressive multiple sclerosis

‘Bedside’ observations challenge aspects of the ‘epithelial barrier hypothesis’

Genetic variation in the clonal bryophyte Hylocomium splendens at hierarchical geographical scales in Scandinavia

The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location

Prognostic genome and transcriptome signatures in colorectal cancers

Cerebrospinal fluid concentration of complement component 4A is increased in first episode schizophrenia

Beta-adrenoceptor drugs and progression to Parkinson’s disease milestones in a large pooled incident cohort

Clinical research, or classical clinical research?

A low-eccentricity migration pathway for a 13-h-period Earth analogue in a four-planet system

Clonidine prevents radiation-induced cell death in human brain organoids

Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

Associations between lifestyle factors and levels of per- and polyfluoroalkyl substances (PFASs), phthalates and parabens in follicular fluid in women undergoing fertility treatment

A safe operating space for humanity

A triple protostar system formed via fragmentation of a gravitationally unstable disk

Cardiovascular protein profiling in patients with first-episode psychosis

A Short Polypeptide Marker Sequence Useful for Recombinant Protein Identification and Purification

Shaping a resilient future in response to COVID-19

Transnational corporations and the challenge of biosphere stewardship

Cerebrospinal fluid proteomic study of two bipolar disorder cohorts

Assessment of transmitral and left atrial appendage flow rate from cardiac 4D-CT

Scientific mobilization of keystone actors for biosphere stewardship

Improvement in indices of cellular protection after psychological treatment for social anxiety disorder

Regulation of fungal decomposition at single-cell level

The soil organic matter decomposition mechanisms in ectomycorrhizal fungi are tuned for liberating soil organic nitrogen

Chaperonin Assisted Phage Display of Antibody Fragments on Filamentous Bacteriophages

Author Correction: Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

Neurofilaments as biomarkers in neurological disorders — towards clinical application

A randomized placebo-controlled PET study of ketamine´s effect on serotonin_1B receptor binding in patients with SSRI-resistant depression

Neurodevelopmental disorders—high-resolution rethinking of disease modeling

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