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Showing 1–9 of 9 results
Advanced filters: Author: Carl-Mikael Suomivuori Clear advanced filters

  • Structural findings define the architecture of the mitochondrial pyruvate carrier, delineate its substrate-binding site and translocation pathway, and reveal its major conformational states, providing the molecular basis for understanding its function and inhibition.

    • Zheng He
    • Jianxiu Zhang
    • Liang Feng
    Research
    Nature
    Volume: 641, P: 250-257

  • Cryo-EM structures of µ-opioid receptor complexes with two agonists coupled to molecular dynamics simulations and functional assays highlight distinct efficacy for G protein subtype activation and β-arrestin recruitment.

    • Qianhui Qu
    • Weijiao Huang
    • Georgios Skiniotis
    Research
    Nature Chemical Biology
    Volume: 19, P: 423-430

  • Cryo-electron microscopy structures of the thyrotropin receptor reveal the basis for the activation of the receptor by autoantibodies in patients with Graves’ disease.

    • Bryan Faust
    • Christian B. Billesbølle
    • Aashish Manglik
    Research
    Nature
    Volume: 609, P: 846-853

  • This manuscript describes the structure of an endocannabinoid analog-bound CB1 complex and reveals the structural determinants of ligand efficacy. The activation mechanism, unique to CB1, that is exploited by allosteric modulators is also outlined.

    • Kaavya Krishna Kumar
    • Michael J. Robertson
    • Brian Kobilka
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • Cryo-electron microscopy structures of human neurotensin receptor 1 in complex with Gi1 protein and the agonist JMV449 reveal a non-canonical state that may represent an intermediate form in G-protein activation.

    • Hideaki E. Kato
    • Yan Zhang
    • Georgios Skiniotis
    Research
    Nature
    Volume: 572, P: 80-85

  • Determination of the cryo-EM structures of active neurokinin-1 receptor bound to substance P or the Gq biased peptide SP6–11 reveals that interactions with the receptor extracellular loops regulate G protein signaling selectivity.

    • Julian A. Harris
    • Bryan Faust
    • Aashish Manglik
    Research
    Nature Chemical Biology
    Volume: 18, P: 109-115