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Showing 101–150 of 349 results

Advanced filters: Author: Carlos Zaragoza Clear advanced filters

Trough to peak ratio of once-daily lisinopril and twice-daily captopril in patients with essential hypertension

N Martell
B Gill
M Luque
Research11 Feb 1998
Journal of Human Hypertension

Volume: 12, P: 69-72
Adherence Of Spanish Primary Physicians And Clinical Practise To The Mediterranean Diet

Ares Sentenach-Carbo
Carme Batlle
Anna Bach-Faig
Research28 Nov 2018
European Journal of Clinical Nutrition

Volume: 72, P: 92-98
The first hominin of Europe

The discovery of a human lower jaw associated with stone tools and animal bones from the Sima del Elefante in northern Spain is reported. The finds have been dated to between 1.1 and 1.2 million years using a variety of dating techniques, making the site the oldest and most accurately dated record of human occupation in Europe.

Eudald Carbonell
José M. Bermúdez de Castro
Juan L. Arsuaga
Research27 Mar 2008
Nature

Volume: 452, P: 465-469
Simulated resilience of tropical rainforests to CO₂-induced climate change

Assessing potential future carbon loss from tropical forests is important for evaluating the efficacy of programmes for reducing emissions from deforestation and degradation (REDD). An exploration of results from 22 climate models in conjunction with a land surface scheme suggests that in the Americas, Africa and Asia, the resilience of tropical forests to climate change is higher than expected, although uncertainties are large.

Chris Huntingford
Przemyslaw Zelazowski
Peter M. Cox
Research10 Mar 2013
Nature Geoscience

Volume: 6, P: 268-273
The unequal effects of the health–economy trade-off during the COVID-19 pandemic

The authors construct a model that captures both health and economic aspects of the coronavirus disease 2019 pandemic, and uncover trade-offs between epidemic and economic outcomes both when individuals change their behaviour due to fear of infection and when non-pharmaceutical interventions are imposed.

Marco Pangallo
Alberto Aleta
J. Doyne Farmer
ResearchOpen Access16 Nov 2023
Nature Human Behaviour

Volume: 8, P: 264-275
Breakfast consumption and its relationship with diet quality and adherence to Mediterranean diet in European adolescents: the HELENA study

Natalia Giménez-Legarre
Alba M. Santaliestra-Pasías
Luis A. Moreno
Research04 Aug 2022
European Journal of Clinical Nutrition

Volume: 76, P: 1690-1696
Nivolumab plus chemotherapy or ipilimumab in gastro-oesophageal cancer

Results in the CheckMate 649 phase 3 trial for first-line combined nivolumab and chemotherapy treatment continue to show clinically meaningful efficacy in gastric, gastro-oesophageal junction or oesophageal adenocarcinoma after 24 months, with no new safety signals.

Kohei Shitara
Jaffer A. Ajani
Yelena Y. Janjigian
ResearchOpen Access23 Mar 2022
Nature

Volume: 603, P: 942-948
Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Contrary to the view that urbanization is a major driver of the global rise in obesity, the global increase in body-mass index is shown to be mostly due to increases in the body-mass indexes of rural populations.

Honor Bixby
James Bentham
Majid Ezzati
ResearchOpen Access08 May 2019
Nature

Volume: 569, P: 260-264
Nanoporous graphene-based thin-film microelectrodes for in vivo high-resolution neural recording and stimulation

Bidirectional neural interface electronic devices offer therapeutic options. Here, the authors present wafer-scale fabrication of flexible nanoporous graphene-based implantable microelectrode arrays with low impedance and high charge injection for in vivo brain recording and nerve stimulation.

Damià Viana
Steven T. Walston
Jose A. Garrido
ResearchOpen Access11 Jan 2024
Nature Nanotechnology

Volume: 19, P: 514-523
Risk factors for developing ventilator-associated lower respiratory tract infection in patients with severe COVID-19: a multinational, multicentre study, prospective, observational study

Luis Felipe Reyes
Alejandro Rodriguez
Neus Guasch
ResearchOpen Access21 Apr 2023
Scientific Reports

Volume: 13, P: 1-15
3D collagen migration patterns reveal a SMAD3-dependent and TGF-β1-independent mechanism of recruitment for tumour-associated fibroblasts in lung adenocarcinoma

Yago Juste-Lanas
Natalia Díaz-Valdivia
Jordi Alcaraz
ResearchOpen Access26 Dec 2022
British Journal of Cancer

Volume: 128, P: 967-981
Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents

Current cysteine bioconjugation strategies for protein-drug conjugates synthesis often yield heterogeneous and poorly stable products. Here, the authors use carbonylacrylic derivatives to selectively modify cysteine residues and synthesize biologically functional antibody conjugates highly stable in plasma.

Barbara Bernardim
Pedro M.S.D. Cal
Gonçalo J. L. Bernardes
ResearchOpen Access26 Oct 2016
Nature Communications

Volume: 7, P: 1-9
Comprehensive molecular profiling of multiple myeloma identifies refined copy number and expression subtypes

Longitudinal genomic and transcriptomic profiling of 1,143 patients with multiple myeloma by the Relating Clinical Outcomes in Multiple Myeloma to Personal Assessment of Genetic Profile study yields an improved copy number and gene expression subtype scheme, most notably a high-risk proliferative subtype associated with complete loss of RB1 or MAX.

Sheri Skerget
Daniel Penaherrera
Jonathan J. Keats
ResearchOpen Access19 Aug 2024
Nature Genetics

Volume: 56, P: 1878-1889
Diagnostic and therapeutic strategies for small abdominal aortic aneurysms

Abdominal aortic aneurysm (AAA) is a common condition that can result in aortic rupture and death. AAA-related mortality continues to rise, highlighting the growing need for effective management strategies. In this Review, the authors discuss the current and future diagnostic and therapeutic strategies for the management of AAA, including the potential of new imaging techniques and novel pharmacological agents.

Ahmed Klink
Fabien Hyafil
Zahi A. Fayad
Reviews08 Feb 2011
Nature Reviews Cardiology

Volume: 8, P: 338-347
Unravelling the cellular response to the SARS-COV-2 vaccine in inflammatory bowel disease patients on biologic drugs

Samuel J. Martínez-Domínguez
Sandra García-Mateo
Pedro M. Baptista
ResearchOpen Access27 Dec 2023
Scientific Reports

Volume: 13, P: 1-11
GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways

Systemic sclerosis (SSc) is a heterogeneous chronic autoimmune disease that affects the connective tissue. Here, López-Isac et al. identify 13 new risk loci for SSc as well as loci specific for limited cutaneous and diffuse SSc and, defining credible sets and performing functional annotation, highlight key pathways and cell types for SSc.

Elena López-Isac
Marialbert Acosta-Herrera
Javier Martin
ResearchOpen Access31 Oct 2019
Nature Communications

Volume: 10, P: 1-14
Author Correction: Comprehensive molecular profiling of multiple myeloma identifies refined copy number and expression subtypes

Sheri Skerget
Daniel Penaherrera
Jonathan J. Keats
Amendments and CorrectionsOpen Access09 Jun 2025
Nature Genetics

Volume: 57, P: 1789
Atrial fibrillation as a new prognosis factor in chronic patients after hospitalization: the CHRONIBERIA index

Javier Suarez-Dono
Ignacio Novo-Veleiro
Antonio Pose-Reino
ResearchOpen Access11 Mar 2023
Scientific Reports

Volume: 13, P: 1-8
A mutation in the POT1 gene is responsible for cardiac angiosarcoma in TP53-negative Li–Fraumeni-like families

Genetic factors that cause cardiac angiosarcoma are unknown. Calveteet al. show that a missense mutation in protection of telomeres1 (POT1) gene causes cardiac angiosarcoma by affecting the POT1 function and, consequently, telomere length and stability.

Oriol Calvete
Paula Martinez
Javier Benítez
ResearchOpen Access25 Sept 2015
Nature Communications

Volume: 6, P: 1-12
Comparison of resistive capacitive energy transfer therapy on cadaveric molars and incisors with and without implants

Albert Pérez-Bellmunt
Jordi Caballé-Serrano
Carlos López-de-Celis
ResearchOpen Access13 Jul 2022
Scientific Reports

Volume: 12, P: 1-8
A novel chimeric antigen receptor T-cell therapy targeting CD84 for the treatment of acute myeloid and T-cell lymphoblastic leukemias

Lorena Pérez-Amill
Mercedes Armand-Ugón
Nela Klein-González
ResearchOpen Access06 Aug 2025
Leukemia

Volume: 39, P: 2432-2441
COVID-19 clinical phenotypes in vaccinated and nonvaccinated solid organ transplant recipients: a multicenter validation study

Carmen Infante-Domínguez
Sonsoles Salto-Alejandre
Alice Toschi
ResearchOpen Access03 Dec 2024
Scientific Reports

Volume: 14, P: 1-13
Rapid northern hemisphere ice sheet melting during the penultimate deglaciation

Stalagmites from NW Iberia record the rapid demise of large ice sheets during the penultimate deglaciation, and reveal decadal-scale feedbacks between warming and ice melting.

Heather M. Stoll
Isabel Cacho
R. Lawrence Edwards
ResearchOpen Access02 Jul 2022
Nature Communications

Volume: 13, P: 1-16
Sampling and processing blood samples within the South American Youth/Child cARdiovascular and Environmental (SAYCARE) Study

Graciela López
Raphael Assali Serruya
Gabriela Berg
ResearchOpen Access20 Jan 2020
Scientific Reports

Volume: 10, P: 1-7
The importance of murine phospho-MLKL-S345 in situ detection for necroptosis assessment in vivo

Konstantinos Kelepouras
Julia Saggau
Gianmaria Liccardi
ResearchOpen Access23 May 2024
Cell Death & Differentiation

Volume: 31, P: 897-909
Molecular characterization of pregnancy-associated breast cancer and insights on timing from GEICAM-EMBARCAM study

Regina Peña-Enríquez
Begoña Bermejo
Juan de la Haba-Rodríguez
ResearchOpen Access08 Feb 2025
npj Breast Cancer

Volume: 11, P: 1-16
Heterogeneity in the association between prediabetes categories and reduction on glomerular filtration rate in a 5-year follow-up

Marjan Manouchehri
Lucía Cea-Soriano
Pedro Muñoz
ResearchOpen Access05 May 2022
Scientific Reports

Volume: 12, P: 1-10
Combined use of a healthy lifestyle smartphone application and usual primary care counseling to improve arterial stiffness, blood pressure and wave reflections: a Randomized Controlled Trial (EVIDENT II Study)

José I. Recio-Rodríguez
Emiliano Rodriguez-Sanchez
Luis Garcia-Ortiz
Research26 Dec 2018
Hypertension Research

Volume: 42, P: 852-862
Prevalence and factors linked to renal involvement in prediabetes patients across Europe in the ePREDICE trial

Sebastián Mas-Fontao
Esther Civantos
Jesús Egido
ResearchOpen Access05 Dec 2024
Scientific Reports

Volume: 14, P: 1-15
Enabling cell recovery from 3D cell culture microfluidic devices for tumour microenvironment biomarker profiling

María Virumbrales-Muñoz
Jose M. Ayuso
Ignacio Ochoa
ResearchOpen Access17 Apr 2019
Scientific Reports

Volume: 9, P: 1-14
Ultra-fast direct growth of metallic micro- and nano-structures by focused ion beam irradiation

Rosa Córdoba
Pablo Orús
José María De Teresa
ResearchOpen Access01 Oct 2019
Scientific Reports

Volume: 9, P: 1-10
Severe encephalopathy associated to pyruvate dehydrogenase mutations and unbalanced coenzyme Q₁₀ content

Claudio Asencio
María A Rodríguez-Hernandez
Plácido Navas
Research27 May 2015
European Journal of Human Genetics

Volume: 24, P: 367-372
Improving transportation networks: Effects of population structure and decision making policies

Federico Pablo-Martí
Angel Sánchez
ResearchOpen Access03 Jul 2017
Scientific Reports

Volume: 7, P: 1-9
Optical bistability via an external control field in all-fiber ring cavity

Shili Li
Qiang Ge
Benli Yu
ResearchOpen Access21 Aug 2017
Scientific Reports

Volume: 7, P: 1-5
Clinical correlates of anti-SARS-CoV-2 antibody profiles in Spanish COVID-19 patients from a high incidence region

Robert Markewitz
Antje Torge
Ralf Junker
ResearchOpen Access23 Feb 2021
Scientific Reports

Volume: 11, P: 1-11
Long-term outcome of older patients with newly diagnosed de novo acute promyelocytic leukemia treated with ATRA plus anthracycline-based therapy

D Martínez-Cuadrón
P Montesinos
M A Sanz
Research06 Jun 2017
Leukemia

Volume: 32, P: 21-29
The heterogeneity of reversion to normoglycemia according to prediabetes type is not explained by lifestyle factors

Carolina Giráldez-García
Lucía Cea-Soriano
Carmen Yuste
ResearchOpen Access06 May 2021
Scientific Reports

Volume: 11, P: 1-11
Effect of LDL cholesterol, statins and presence of mutations on the prevalence of type 2 diabetes in heterozygous familial hypercholesterolemia

Elisenda Climent
Sofía Pérez-Calahorra
Juan Pedro-Botet
ResearchOpen Access17 Jul 2017
Scientific Reports

Volume: 7, P: 1-8
Gastrointestinal effects of aspirin

Aspirin is one of the most prescribed drugs worldwide, as it can prevent cardiovascular morbidity and mortality. However, aspirin can cause gastrointestinal complications. In this Review, Angel Lanas and Carlos Sostres discuss the gastrointestinal effects of aspirin and suggest that physicians need to consider the advantages and risks for individual patients to maximize the benefits of aspirin.

Carlos Sostres
Angel Lanas
Reviews04 Jul 2011
Nature Reviews Gastroenterology & Hepatology

Volume: 8, P: 385-394
Association between adherence to the EAT-Lancet sustainable reference diet and cardiovascular health among European adolescents: the HELENA study

Leandro Teixeira Cacau
Giles T. Hanley-Cook
Luis A. Moreno
Research13 Dec 2023
European Journal of Clinical Nutrition

Volume: 78, P: 202-208
Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice

Fecal microbiome transplantation or probiotic therapy with Akkermansia muciniphila extends the lifespan and improves the health status of progeroid mice, pointing to the importance of the gut microbiome in regulating lifespan and healthspan.

Clea Bárcena
Rafael Valdés-Mas
Carlos López-Otín
Research22 Jul 2019
Nature Medicine

Volume: 25, P: 1234-1242
In vitro synergy screens of FDA-approved drugs reveal novel zidovudine- and azithromycin-based combinations with last-line antibiotics against Klebsiella pneumoniae

Marta Gómara-Lomero
Ana Isabel López-Calleja
Santiago Ramón-García
ResearchOpen Access02 Sept 2023
Scientific Reports

Volume: 13, P: 1-16
Emergence of network features from multiplexity

Alessio Cardillo
Jesús Gómez-Gardeñes
Stefano Boccaletti
ResearchOpen Access27 Feb 2013
Scientific Reports

Volume: 3, P: 1-6
Genetic landscape of 6089 inherited retinal dystrophies affected cases in Spain and their therapeutic and extended epidemiological implications

Irene Perea-Romero
Gema Gordo
Carmen Ayuso
ResearchOpen Access15 Jan 2021
Scientific Reports

Volume: 11, P: 1-13
Author Correction: dsRNAi-mediated silencing of PIAS2beta specifically kills anaplastic carcinomas by mitotic catastrophe

Joana S. Rodrigues
Miguel Chenlo
Clara V. Alvarez
Amendments and CorrectionsOpen Access11 Jul 2024
Nature Communications

Volume: 15, P: 1
Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing

Conplastic mice that share the same nuclear genome but have different mitochondrial DNA were analysed throughout their life — the mitochondrial genome affects many aspects of physiology and results in differences in median lifespan; the authors propose that the interplay of mitochondrial and nuclear genomes may be an important factor influencing this phenomenon.

Ana Latorre-Pellicer
Raquel Moreno-Loshuertos
José Antonio Enríquez
Research06 Jul 2016
Nature

Volume: 535, P: 561-565
The FAD synthetase from the human pathogen Streptococcus pneumoniae: a bifunctional enzyme exhibiting activity-dependent redox requirements

María Sebastián
Erandi Lira-Navarrete
Marta Martínez-Júlvez
ResearchOpen Access08 Aug 2017
Scientific Reports

Volume: 7, P: 1-15
Cytolytic γδ T-cells and IFNγ-producing CD4-lymphocytes characterise the early response to MTBVAC tuberculosis vaccine

María-José Felgueres
Gloria Esteso
Mar Valés-Gómez
ResearchOpen Access28 Mar 2025
npj Vaccines

Volume: 10, P: 1-12
Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder

GEMIN5, an RNA-binding protein, is required for formation of small nuclear ribonucleoproteins. Here, the authors identify loss of function mutations in GEMIN5 that are associated with a human neurodevelopmental disorder.

Sukhleen Kour
Deepa S. Rajan
Udai Bhan Pandey
ResearchOpen Access07 May 2021
Nature Communications

Volume: 12, P: 1-15
Global analysis reveals climatic controls on the oxygen isotope composition of cave drip water

δ¹⁸O of speleothems are a widely used paleoclimate proxy. Here, the authors conduct a global analysis of cave drip water δ¹⁸O compositions and find that drip waters from warmer climates have a seasonal bias toward precipitation δ¹⁸O of recharge periods, unlike in cooler climates where drip waters match well with recharge-weighted δ¹⁸O.

Andy Baker
Andreas Hartmann
Martin Werner
ResearchOpen Access05 Jul 2019
Nature Communications

Volume: 10, P: 1-7

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