Nature Search

Polygenic and developmental profiles of autism differ by age at diagnosis

A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.

Xinhe Zhang
Jakob Grove
Varun Warrier
ResearchOpen Access01 Oct 2025
Nature

P: 1-12
Transgenic plants protected from insect attack

Mark Vaeck
Arlette Reynaerts
Jan Leemans
Research02 Jul 1987
Nature

Volume: 328, P: 33-37
Individual variations in glycemic responses to carbohydrates and underlying metabolic physiology

Deep phenotyping of responses to carbohydrate meals and mitigators revealed interindividual differences in postprandial glycemic responses that reflect underlying metabolic physiology, such as insulin resistance and beta cell dysfunction.

Yue Wu
Ben Ehlert
Michael P. Snyder
ResearchOpen Access04 Jun 2025
Nature Medicine

Volume: 31, P: 2232-2243
Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats

Timothy J. Aitman
Takanari Gotoda
James Scott
Research01 Jun 1997
Nature Genetics

Volume: 16, P: 197-201
Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses

Study shows PTSD predisposition shares distinct genes and genomic regions with several cardiovascular conditions. Here the findings reveal neuronal, immune, and metabolic pathways, and repurposed drug targets that further the understanding of the comorbidity.

Jie Shen
Wander Valentim
Gita A. Pathak
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-17
The health effects associated with physical, sexual and psychological gender-based violence against men and women: a Burden of Proof study

Gender-based violence is widespread, affecting women and men worldwide. Stein et al. use a meta-analysis and the Burden of Proof methodology to evaluate associations between gender-based violence and eight health outcomes, including major depressive disorder, substance use and reproductive health.

Caroline Stein
Luisa S. Flor
Emmanuela Gakidou
ResearchOpen Access10 Apr 2025
Nature Human Behaviour

Volume: 9, P: 1201-1216
Health effects associated with exposure of children to physical violence, psychological violence and neglect: a Burden of Proof study

Around the world, more than a billion children are regularly exposed to violence or neglect. Flor et al. systematically review evidence that links childhood physical violence, psychological violence and neglect to increased risks for 14 health outcomes.

Luisa S. Flor
Caroline Stein
Emmanuela Gakidou
ResearchOpen Access10 Apr 2025
Nature Human Behaviour

Volume: 9, P: 1217-1236
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder

Multi-ancestry genome-wide analyses identify 95 loci associated with post-traumatic stress disorder and implicate candidate genes, pathways and neurobiological systems underlying its pathophysiology.

Caroline M. Nievergelt
Adam X. Maihofer
Karestan C. Koenen
Research18 Apr 2024
Nature Genetics

Volume: 56, P: 792-808
Seedling root system adaptation to water availability during maize domestication and global expansion

Characterization of seminal root number variation in the root systems of >9,000 global maize accessions and its wild relatives provides insights into root trait adaptation to environments during domestication and global expansion.

Peng Yu
Chunhui Li
Frank Hochholdinger
Research22 May 2024
Nature Genetics

Volume: 56, P: 1245-1256
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

Stig Bojesen, Georgia Chenevix-Trench, Alison Dunning and colleagues report common variants at the TERT-CLPTM1L locus associated with mean telomere length measured in whole blood. They also identify associations at this locus to breast or ovarian cancer susceptibility and report functional studies in breast and ovarian cancer tissue and cell lines.

Stig E Bojesen
Karen A Pooley
Alison M Dunning
Research27 Mar 2013
Nature Genetics

Volume: 45, P: 371-384
Heritable microbiome variation is correlated with source environment in locally adapted maize varieties

He et al. found that locally adapted maize varieties exert patterns of genetic control on their root and rhizosphere microbiomes that follow variation in their home environments, consistent with a role in tolerance to prevailing stress.

Xiaoming He
Danning Wang
Peng Yu
Research21 Mar 2024
Nature Plants

Volume: 10, P: 598-617
Genetic mechanisms of critical illness in COVID-19

A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

Erola Pairo-Castineira
Sara Clohisey
J. Kenneth Baillie
Research11 Dec 2020
Nature

Volume: 591, P: 92-98
A remnant planetary core in the hot-Neptune desert

Observations of TOI-849b reveal a radius smaller than Neptune’s but a large mass of about 40 Earth masses, indicating that the planet is the remnant core of a gas giant.

David J. Armstrong
Théo A. Lopez
Zhuchang Zhan
Research01 Jul 2020
Nature

Volume: 583, P: 39-42
KIF1C activates and extends dynein movement through the FHF cargo adapter

Here the authors show that codependence of dynein and kinesin KIF1C occurs through binding of the FTS–HOOK3–FHIP1B cargo adapter. Binding of KIF1C releases the HOOK3 autoinhibited folded conformation allowing dynein to bind the adapter. In this cocomplex, KIF1C further acts as a processivity factor for dynein.

Ferdos Abid Ali
Alexander J. Zwetsloot
Anne Straube
ResearchOpen Access02 Jan 2025
Nature Structural & Molecular Biology

Volume: 32, P: 756-766
Health effects associated with exposure to intimate partner violence against women and childhood sexual abuse: a Burden of Proof study

A meta-analysis using the burden of proof risk function identified consistent evidence supporting harmful associations between the exposure to intimate partner violence against women and childhood sexual abuse on health outcomes.

Cory N. Spencer
Mariam Khalil
Emmanuela Gakidou
ResearchOpen Access11 Dec 2023
Nature Medicine

Volume: 29, P: 3243-3258
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

A cross-ancestry genome-wide association meta-analysis of amyotrophic lateral sclerosis (ALS) including 29,612 patients with ALS and 122,656 controls identifies 15 risk loci with distinct genetic architectures and neuron-specific biology.

Wouter van Rheenen
Rick A. A. van der Spek
Jan H. Veldink
ResearchOpen Access06 Dec 2021
Nature Genetics

Volume: 53, P: 1636-1648
International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

Post-traumatic stress disorder (PTSD) is a common mental health problem. Here, the authors report a GWAS from the Psychiatric Genomics Consortium in which they identify two risk loci in European ancestry and one locus in African ancestry individuals and find that PTSD is genetically correlated with several other psychiatric traits.

Caroline M. Nievergelt
Adam X. Maihofer
Karestan C. Koenen
ResearchOpen Access08 Oct 2019
Nature Communications

Volume: 10, P: 1-16
Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148

Genetic variants at multiple loci of chr5p15.33 have been associated with susceptibility to numerous cancers. Here the authors show that the association of one of these loci may be explained by a variant, rs36115365, influencing telomerase reverse transcriptase (TERT) expression via ZNF148.

Jun Fang
Jinping Jia
Laufey T. Amundadottir
ResearchOpen Access27 Apr 2017
Nature Communications

Volume: 8, P: 1-17
Aberrant neural computation of social controllability in nicotine-dependent humans

A neurocomputational model of social forward thinking shows that smokers under-estimate the influence of their actions on future interactions, a cognitive deficit associated with aberrant prefrontal and midbrain activities.

Caroline McLaughlin
Qi Xiu Fu
Xiaosi Gu
ResearchOpen Access14 Aug 2024
Communications Biology

Volume: 7, P: 1-11
Rare coding variation provides insight into the genetic architecture and phenotypic context of autism

Analysis of rare protein-truncating, damaging missense and copy number variants from exome sequencing of 63,237 individuals identifies 72 genes associated with autism spectrum disorder.

Jack M. Fu
F. Kyle Satterstrom
Michael E. Talkowski
Research18 Aug 2022
Nature Genetics

Volume: 54, P: 1320-1331
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16
Antidepressant-like Effects of Buprenorphine are Mediated by Kappa Opioid Receptors

Edgardo Falcon
Caroline A Browne
Irwin Lucki
Research16 Mar 2016
Neuropsychopharmacology

Volume: 41, P: 2344-2351
Proteins containing the UBA domain are able to bind to multi-ubiquitin chains

Caroline R.M. Wilkinson
Michael Seeger
Colin Gordon
Research13 Sept 2001
Nature Cell Biology

Volume: 3, P: 939-943
v-Abl protein tyrosine kinase (PTK) mediated suppression of apoptosis is associated with the up-regulation of Bcl-X_L

Quan Chen
Jonathan Turner
Caroline Dive
Research30 Oct 1997
Oncogene

Volume: 15, P: 2249-2254
Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group

Sarah M. C. Colbert
Eric T. Monson
Lea Zillich
ReviewsOpen Access25 Sept 2025
Molecular Psychiatry

P: 1-11
Trauma and posttraumatic stress disorder modulate polygenic predictors of hippocampal and amygdala volume

Yuanchao Zheng
Melanie E. Garrett
Rajendra A. Morey
ResearchOpen Access16 Dec 2021
Translational Psychiatry

Volume: 11, P: 1-10
The association of food insecurity with mental health in preschool-aged children and their parents

Gabriella Dean
Mara Z. Vitolins
Callie L. Brown
Research04 Jan 2023
Pediatric Research

Volume: 94, P: 290-295
Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis

Leonard van den Berg, Roel Ophoff and colleagues present a genome-wide association study of sporadic amyotrophic lateral sclerosis. The work uncovers associated SNPs at 9p21.2 and an associated locus at 19p13.3 mapping to the UNC13A gene.

Michael A van Es
Jan H Veldink
Leonard H van den Berg
Research06 Sept 2009
Nature Genetics

Volume: 41, P: 1083-1087
Rare copy number variation in posttraumatic stress disorder

Adam X. Maihofer
Worrawat Engchuan
Caroline M. Nievergelt
ResearchOpen Access21 Sept 2022
Molecular Psychiatry

Volume: 27, P: 5062-5069
Effects of genetically predicted posttraumatic stress disorder on autoimmune phenotypes

Adam X. Maihofer
Andrew Ratanatharathorn
Caroline M. Nievergelt
ResearchOpen Access01 Apr 2024
Translational Psychiatry

Volume: 14, P: 1-10
Dense magnetized plasma associated with a fast radio burst

Fast radio burst FRB 110523, discovered in archival data, reveals Faraday rotation and scattering that suggests dense magnetized plasma near the source; this means that to infer the source of the burst, models should involve young stellar populations such as magnetars.

Kiyoshi Masui
Hsiu-Hsien Lin
Jaswant K. Yadav
Research02 Dec 2015
Nature

Volume: 528, P: 523-525
Genetic determinants of right-ventricular remodeling after tetralogy of Fallot repair

Aamir Jeewa
Ashok Kumar Manickaraj
Seema Mital
Research13 Jul 2012
Pediatric Research

Volume: 72, P: 407-413
NEK1 variants confer susceptibility to amyotrophic lateral sclerosis

Jan Veldink and colleagues show that loss-of-function variants in NEK1 are associated with susceptibility to amyotrophic lateral sclerosis (ALS). In addition to finding an excess of rare loss-of-function NEK1 variants in ALS cases, they report a significant association between a specific NEK1 missense variant (p.Arg261His) and disease risk.

Kevin P Kenna
Perry T C van Doormaal
John E Landers
Research25 Jul 2016
Nature Genetics

Volume: 48, P: 1037-1042
Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus

Sébastien Jacquemont
Alexandre Reymond
Philippe Froguel
Research31 Aug 2011
Nature

Volume: 478, P: 97-102
Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

Wouter van Rheenen
Rick A. A. van der Spek
Jan H. Veldink
Amendments and CorrectionsOpen Access31 Jan 2022
Nature Genetics

Volume: 54, P: 361
De novo variants in SNAP25 cause an early-onset developmental and epileptic encephalopathy

Chiara Klöckner
Heinrich Sticht
Konrad Platzer
Research10 Dec 2020
Genetics in Medicine

Volume: 23, P: 653-660
Correction to: De novo variants in SNAP25 cause an early-onset developmental and epileptic encephalopathy

Chiara Klöckner
Heinrich Sticht
Konrad Platzer
Amendments and Corrections08 Mar 2021
Genetics in Medicine

Volume: 23, P: 796
Nicotine-Associated Cues Maintain Nicotine-Seeking Behavior in Rats Several Weeks after Nicotine Withdrawal: Reversal by the Cannabinoid (CB₁) Receptor Antagonist, Rimonabant (SR141716)

Caroline Cohen
Ghislaine Perrault
Philippe Soubrié
Research04 Aug 2004
Neuropsychopharmacology

Volume: 30, P: 145-155
Signatures of malaria-associated pathology revealed by high-resolution whole-blood transcriptomics in a rodent model of malaria

Jing-wen Lin
Jan Sodenkamp
Jean Langhorne
ResearchOpen Access03 Feb 2017
Scientific Reports

Volume: 7, P: 1-13
The Relationship of Antiphospholipid Antibodies to Thromboembolic Events in Pediatric Patients with Systemic Lupus Erythematosus: A Cross-Sectional Study

Caroline Berube
Lesley Mitchell
Maureen Andrew
Research01 Sept 1998
Pediatric Research

Volume: 44, P: 351-356
Fox Insight collects online, longitudinal patient-reported outcomes and genetic data on Parkinson’s disease

Luba Smolensky
Ninad Amondikar
Caroline Tanner
ResearchOpen Access24 Feb 2020
Scientific Data

Volume: 7, P: 1-9

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