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Showing 1–6 of 6 results
Advanced filters: Author: Carolyne M. Ndila Clear advanced filters

  • A strong association has been found between three regions of the Plasmodium falciparum genome and sickle haemoglobin in children with severe malaria, suggesting parasites have adapted to overcome natural host immunity.

    • Gavin Band
    • Ellen M. Leffler
    • Dominic P. Kwiatkowski
    ResearchOpen Access
    Nature
    Volume: 602, P: 106-111

  • Estimates of the burden of malaria often don't take wider, indirect effects on overall health into consideration. Here, Uyoga et al. estimate the indirect impact of malaria on children’s health in a case-control study, using the sickle cell trait as a proxy indicator for an effective intervention.

    • Sophie Uyoga
    • Alex W. Macharia
    • Thomas N. Williams
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-7

  • Four genome-wide associated loci are currently known for malaria susceptibility. Here, the authors expand on earlier work by combining data from 11 malaria-endemic countries and additional population sequencing informing an African-enriched imputation reference panel, with findings including a previously unreported association on chromosome 6.

    • Gavin Band
    • Quang Si Le
    • Dominic P. Kwiatkowski
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-19

  • The Malaria Genomic Epidemiology Network reports a large multicenter association study for severe malaria due to Plasmodium falciparum in 11,890 cases and 17,441 controls from 12 locations in Africa, Asia and Oceania. They examine 27 loci previously associated with severe malaria and replicate associations at the HBB, ABO, ATP2B4, G6PD and CD40LG loci, but they fail to replicate other previously reported associations.

    • Kirk A Rockett
    • Geraldine M Clarke
    • Dominic P Kwiatkowski
    Research
    Nature Genetics
    Volume: 46, P: 1197-1204