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Showing 1–5 of 5 results
Advanced filters: Author: Carson C. Thoreen Clear advanced filters

  • mTORC1 is shown to regulate a translational program that requires the rapamycin-resistant 4E-BP family of translational repressors and consists almost entirely of mRNAs containing 5′ terminal oligopyrimidine or related motifs.

    • Carson C. Thoreen
    • Lynne Chantranupong
    • David M. Sabatini
    Research
    Nature
    Volume: 485, P: 109-113

  • A rationally designed class of mTORC1 inhibitors combines the selectivity of rapamycin with the potency of mTOR kinase inhibitors.

    • Carson C. Thoreen
    News & Views
    Nature Chemical Biology
    Volume: 17, P: 1012-1013

  • A new study identifies a protective role for cellular aggregates in Huntington disease by showing that aggregates promote the clearance of mutant protein by activating autophagy through the inhibition of mTOR. This challenges the common view that they are possibly innocuous but probably harmful to the host cell.

    • Carson C Thoreen
    • David M Sabatini
    News & Views
    Nature Genetics
    Volume: 36, P: 553-554