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Showing 1–11 of 11 results
Advanced filters: Author: Catherine A Vickers Clear advanced filters

  • We need a fresh approach to conducting clinical trials. Our present system is in serious need of an overhaul. Regulatory guidelines need to be re-evaluated, as they present significant barriers and cause delays.

    • E. David Crawford
    • Catherine M. Tangen
    News & Views
    Nature Reviews Urology
    Volume: 6, P: 297-298

  • Metabolic enzymes of the tricarboxylic acid cycle, such as 2-oxoglutarate dehydrogenase, are differentially expressed in absorptive and secretory lineages, guiding cell fate establishment and offering insights for targeted regenerative therapies.

    • Almudena Chaves-Perez
    • Scott E. Millman
    • Scott W. Lowe
    ResearchOpen Access
    Nature
    Volume: 643, P: 468-477

  • During February–June 2024 we conducted four surveys among researchers regarding the likely existence of basic, complex, and intelligent extraterrestrial life. Our results offer a snapshot of community opinion and reveal a significant degree of consensus that extraterrestrial life is likely to exist.

    • Peter Vickers
    • Emma Gardiner
    • Sean McMahon
    Comments & Opinion
    Nature Astronomy
    Volume: 9, P: 16-18

  • Grant and colleagues used comparative proteomics and genomics to examine the evolution of the postsynaptic density and MAGUK-associated signaling complexes implicated in learning and memory. They found conservation of synaptic components amidst diverse species, but also found species-specific adaptation and increased signaling complexity in vertebrates.

    • Richard D Emes
    • Andrew J Pocklington
    • Seth G N Grant
    Research
    Nature Neuroscience
    Volume: 11, P: 799-806

  • Several different viruses have a role in cancer pathogenesis, contributing to the development of various haematological malignancies and solid tumours via diverse, multifaceted mechanisms. However, this viral aetiology presents a unique opportunity for adoptive virus-specific T cell (VST) therapy. This Review summarizes the mechanisms of viral carcinogenesis and describes the current clinical experience with adoptive cellular immunotherapies for virus-related cancers, predominantly using non-genetically modified VSTs. The authors also discuss challenges and future directions for the ongoing clinical development of VST therapies.

    • Keri Toner
    • Chase D. McCann
    • Catherine M. Bollard
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 21, P: 709-724

  • Is the scientific status of astrobiology undermined by the lack of evidence for alien life, the problematic influence of science fiction, or the use of ‘astrobiology’ as a buzzword for attracting funding? Here we defend the emerging discipline.

    • Cyrille Jeancolas
    • Catherine Gillen
    • Peter Vickers
    Comments & Opinion
    Nature Astronomy
    Volume: 8, P: 5-7

  • Radiotherapy has been driven by constant technological advances since the discovery of X rays in 1895. This Timeline article covers the history of radiotherapy and focuses on the advances of major importance in the past two decades. These changes have provided clinical benefit for patients with cancer.

    • Juliette Thariat
    • Jean-Michel Hannoun-Levi
    • Jean-Pierre Gérard
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 10, P: 52-60