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In the context of parental or diet-induced obesity, preweaning ketosis contributes to improved health outcomes, particularly by regulating the histone acetylome and β-hydroxybutyrylome for transcriptional activation of beige fat biogenesis genes.

Temporal integration throughout the human auditory cortex is predominantly locked to absolute time and does not vary with the duration of speech structures such as phonemes or words.

A memory technology that combines the functions of memristors and ferroelectric capacitors in a single stack can be used for on-chip training and inference of artificial neural networks.

Helen Brabham is a team leader at 2Blades, where her work focuses on discovering sustainable approaches for eradicating plant diseases. Helen talks to Nature Plants about her experiences in academia and industry and how researchers can bridge the gap between these two worlds.

UTe₂ is a proposed intrinsic topological superconductor, but its quasiparticle surface band has not yet been visualized. Now this is achieved using quasiparticle interference imaging, revealing the symmetry of the superconducting order parameter.

The distribution of long-lived radiogenic isotopes along the world's mid-ocean ridges can be used to map geochemical domains, reflecting contrasting refilling modes of the upper mantle. Refilling of the upper mantle in the Atlantic and Indian domains is slow and confined to localized upwellings, whereas in the Pacific, upwellings are comparatively much wider and more rapid.

Gradients of cell recognition molecules wire a sensorimotor interface in Drosophila.

The placenta plays vital roles in supporting fetal development. Here, Richards et al. develop a high-throughput bioprinted trophoblast organoid model to recapitulate the microenvironment of the early placenta, enabling investigation of placenta development and evaluation of therapeutics for placenta dysfunction disorders.

Defects in materials can be used to detect magnetic fields at the nanoscale. Here the authors show that a carbon-related defect in hexagonal boron nitride acts as a robust nanoscale sensor capable of vectorial magnetic field detection.

Dual cyclin A/B RxL inhibitors selectively kill small cell lung cancer cells and other cancer cells with high E2F activity.

A survey of geoscience researchers from across Africa highlights key challenges in conducting impactful research. Improved access to skills training can boost research success.

Perineural invasion and cancer-induced nerve injury of tumour-associated nerves are associated with poor response to anti-PD-1 therapy, which can be reversed by combining anti-PD-1 therapy with anti-inflammatory interventions.

Elaborate traits like birdsong are thought to be sexually selected in males but are poorly understood in females. This study shows that year-round territoriality and biparental care are selected for female birdsong, whereas migration, seasonal territoriality, and loss of male care led to losses of female song.

Loggerhead sea turtles, which undergo long-distance migrations, can learn magnetic signatures associated with different geographic areas and have two different magnetic senses, each based on a different underlying mechanism.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Pathology-oriented multiplexing (PathoPlex) represents a framework for widespread access to multiplexed imaging and computational image analysis of clinical specimens at a relatively high throughput and subcellular resolution.

Johannes Krause et al. synthesized seagrass carbon stock data from 2700+ soil cores to find that they vary by plant functional group and coastal setting, indicating where conservation efforts would most effectively avoid emissions from seagrass loss

Three independent theoretical approaches are used to assess the efficiency of the electromagnetic wave mode radiation at the plasma frequency from beam-generated sources during type III solar radio bursts, with parameters close to realistic conditions.

The authors assess the growing field of climate change health impact attribution. They show literature bias towards direct heat effects and extreme weather in high-income countries, highlighting the lack of global representation in current efforts.

Here the authors apply machine learning approaches to Alzheimer’s genetics, confirm known associations and suggest novel risk loci. These methods demonstrate predictive power comparable to traditional approaches, while also offering potential new insights beyond standard genetic analyses.

Wearable sensors typically require innovative methods of energy harvesting for low-power electronics. Here, the authors present an adaptive power management system with a trimodal energy harvesting approach.

A range of mechanisms has been proposed for large-scale folding in polar ice sheets. Here, using new three-dimensional reconstructions of such folds in the onset region of the Greenland Petermann Glacier, the authors show that these formed due to flow convergence and the high mechanical anisotropy of ice.

Materials which simultaneously exhibit superconductivity and topologically non-trivial electronic band structure possess potential applications in quantum computing but have yet to be found. Here, the authors find superconductivity in MoTe₂, a material predicted to be topologically non-trivial.

Analysis of data from multiple instruments reveals a giant exoplanet in orbit around the 0.2-solar-mass star TOI-6894. The existence of this exoplanetary system challenges assumptions about planet formation and it is an excellent target for atmospheric characterization.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

An expert-elicitation process identifies current methodological barriers for monitoring terrestrial biodiversity, and how technological and procedural development of robotic and autonomous systems may contribute to overcoming these challenges.

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

In this study, the authors assess the global response to the toxic aldehyde glyoxal (GO) in Pseudomonas aeruginosa, suggesting that GO controls quorum sensing during infection through a mechanism involving a novel protein, ArqI.

Globally, Black people have some of the highest rates of cardiovascular disease. Racial inequities in cardiovascular health must be tackled. Black In Cardio is a trainee-led initiative aimed at promoting Black people in the cardiovascular field and raising awareness about issues related to the cardiovascular health of Black communities.

The arcuate fascicle connection with the middle temporal gyrus has been considered unique to humans. Using high-resolution diffusion MRI, the authors systematically show this connection in chimpanzees, suggesting a gradual evolution of the language network.

Epitaxial BaTiO₃ ultra scaled nanoislands (30−60 nm) on Si exhibit an electrically switchable topological center down-convergent polar pattern. The peculiar island shape induces a lateral swirling component, which confers chirality to the polar domains.

The authors report shotgun sequences from airborne environmental DNA samples, identifying local biodiversity and enabling deeper analysis of specific species and genomic regions of interest.

Far-field mid-infrared spectroscopy reveals both the electroluminescence of hyperbolic phonon polaritons of hexagonal boron nitride excited by strongly biased graphene, and the associated radiative energy transfer through the material.

Waves breaking on sandy beaches globally contribute a similar amount of dissolved silicon to oceans as that from rivers, according to a global analysis informed by experiments performed on a simulated quartz sand beach.

Song et al. developed a computational tool to profile binding pairs between tumor-derived antigens and antibodies from high-throughput B cell receptor sequencing data, predicting response to immune-checkpoint inhibitor therapy and risk of adverse events.

Kumar et al. show that under glucose-depleted conditions, neurons can use fatty acids as an alternative source of energy to support synaptic function.