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Showing 1–8 of 8 results
Advanced filters: Author: Cathryn R. Cadwell Clear advanced filters

  • Layer 4 of the mammalian neocortex is important for cortical information processing but its cellular composition and local circuits remains elusive. The authors compared two primary sensory cortical areas of mice and found differences in cell composition and local connectivity.

    • Federico Scala
    • Dmitry Kobak
    • Andreas Savas Tolias
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Immunotherapy has yet to demonstrate efficacy for patients with glioblastoma. Here, the authors employ human single-cell RNA-seq, spatial transcriptomics, and a preclinical mouse model to show that glioblastoma cell-derived synaptogenic factor Thrombospondin-1 promotes neuronal circuit remodeling and regional immunosuppression, highlighting a potential therapeutic target.

    • Takahide Nejo
    • Saritha Krishna
    • Hideho Okada
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Brain slices offer an experimental window into human neurophysiology. Using high-density microelectrode array recordings and adeno-associated virus–mediated optogenetics, the authors demonstrate that optogenetic targeting of CAMK2A+ neurons can affect network activity in human hippocampal slices.

    • John P. Andrews
    • Jinghui Geng
    • Tomasz Jan Nowakowski
    Research
    Nature Neuroscience
    Volume: 27, P: 2487-2499

  • The BRAIN Initiative Cell Census Network has constructed a multimodal cell census and atlas of the mammalian primary motor cortex in a landmark effort towards understanding brain cell-type diversity, neural circuit organization and brain function.

    • Edward M. Callaway
    • Hong-Wei Dong
    • Susan Sunkin
    ResearchOpen Access
    Nature
    Volume: 598, P: 86-102

  • Single-cell or single-nucleus RNA-sequencing experiments form a basis for biological insights about cell types and states, but they require orthogonal experiments to confirm the functional relevance of their findings. Here the authors discuss options to support such findings and their challenges.

    • Marco Colonna
    • Genevieve Konopka
    • Naomi Habib
    Reviews
    Nature Neuroscience
    Volume: 27, P: 2310-2325