Despite the important role that NAD plays in axon maintenance and degeneration, an understanding of how NMNAT2 expression, a terminal enzyme for NAD production, influences retinal ganglion cell degeneration is lacking. Here the authors demonstrate epigallocatechin gallate (EGCG) drives NAD production in neurons through an NMNAT2 dependent mechanism and provides neuroprotection against retinal ganglion cell injury ex vivo.
- James R. Tribble
- Melissa Jöe
- Pete A. Williams
