Nature Search

Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose

Responses to SARS-CoV-2 vaccines in different populations are important to define efficacy. Here the authors show using a cohort in Singapore that two doses of mRNA vaccine is less effective in recipients over 60 years of age and that a further dose of vaccine can improve these antibody levels.

Laurent Renia
Yun Shan Goh
Lisa F. P. Ng
ResearchOpen Access08 Aug 2022
Nature Communications

Volume: 13, P: 1-16
Untargeted metabolomics reveals key pathways in miscarriage: steroid, folate, fatty acid & glycosaminoglycan metabolism

Chee Wai Ku
Yu Bin Tan
Yie Hou Lee
ResearchOpen Access13 Jun 2025
npj Women's Health

Volume: 3, P: 1-11
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity

Gene expression is regulated by enhancers and super-enhancers, which can be identified by chromatin profiling. Here, the authors surveyed gastric cancer samples and cell lines to identify enhancer elements exhibiting somatic alterations.

Wen Fong Ooi
Manjie Xing
Patrick Tan
ResearchOpen Access28 Sept 2016
Nature Communications

Volume: 7, P: 1-17
SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

Although extrapulmonary complications of different organ systems are recognized in patients with severe COVID19 effects are less well studied. Here, Qiao et al. characterize the pathogenesis of SARS-CoV-2 on bone metabolism in Syrian hamster and find that bone loss is associated with virus-mediated cytokine dysregulation.

Wei Qiao
Hui En Lau
Kelvin Wai-Kwok Yeung
ResearchOpen Access09 May 2022
Nature Communications

Volume: 13, P: 1-16
Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients

Characterisation of the human antibody response to SARS-CoV-2 can help the design of serological tests and vaccines. Here, the authors identify two linear epitopes in SARS-CoV-2 spike protein that elicit neutralising antibodies in several patients and could thus be useful for serology and vaccine development.

Chek Meng Poh
Guillaume Carissimo
Lisa F. P. Ng
ResearchOpen Access01 Jun 2020
Nature Communications

Volume: 11, P: 1-7
Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19

COVID-19 severity is associated with cytokine levels and lymphopenia, but the role of immune cell subsets is not well understood. Here the authors immunophenotype whole blood samples from 54 COVID-19 patients and find that the immature neutrophil-to-VD2 T-cell ratio is associated with severe COVID-19.

Guillaume Carissimo
Weili Xu
Lisa FP Ng
ResearchOpen Access16 Oct 2020
Nature Communications

Volume: 11, P: 1-12
25-years Trends and Risk factors related to Surgical Outcomes of Giant Retinal Tear-Rhegmatogenous Retinal Detachments

Daniel S. W. Ting
Valencia H. X. Foo
Shu Yen Lee
ResearchOpen Access25 Mar 2020
Scientific Reports

Volume: 10, P: 1-8
Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing

EGFR mutant lung adenocarcinoma (LUAD) exhibit diverse clinical outcomes in response to targeted therapies. Here the authors show that these LUADs involve a complex genomic landscape with high intratumor heterogeneity, providing insights into the evolutionary trajectory of oncogene-driven LUAD and potential mediators of EGFR TKI resistance.

Rahul Nahar
Weiwei Zhai
Daniel S. W. Tan
ResearchOpen Access15 Jan 2018
Nature Communications

Volume: 9, P: 1-11
Genomic landscape of lung adenocarcinoma in East Asians

Genomic and transcriptomic analysis of lung adenocarcinoma (LUAD) in Asia indicates that Asian LUADs have fewer mutations, lower driver prevalence and fewer copy number alterations than European LUADs.

Jianbin Chen
Hechuan Yang
Weiwei Zhai
Research03 Feb 2020
Nature Genetics

Volume: 52, P: 177-186
Novel approach using serum progesterone as a triage to guide management of patients with threatened miscarriage: a prospective cohort study

Thiam Chye Tan
Chee Wai Ku
Nguan Soon Tan
ResearchOpen Access04 Jun 2020
Scientific Reports

Volume: 10, P: 1-7
A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma

The MET receptor is frequently activated in cancer. Here, the authors show that in head and neck and lung squamous carcinoma, a polymorphic MET variant enhances binding to HER2, resulting in activation of HER2 signalling and progression of the cancers.

Li Ren Kong
Nur Afiqah Binte Mohamed Salleh
Boon Cher Goh
ResearchOpen Access25 Mar 2020
Nature Communications

Volume: 11, P: 1-14
Anti-retinal autoantibodies in myopic macular degeneration: a pilot study

Shaun Sebastian Sim
Chee Wai Wong
Chui Ming Gemmy Cheung
Research28 Oct 2020
Eye

Volume: 35, P: 2254-2259
Nanoscale chromatin profiling of gastric adenocarcinoma reveals cancer-associated cryptic promoters and somatically acquired regulatory elements

Epigenetic alterations alter chromatin structure and gene expression and are known contributors to cancer development. Here, Muratani et al.profile multiple epigenetic chromatin marks in primary gastric cancers and identify hundreds of altered promoters and enhancers that drive the gene expression program in these malignancies.

Masafumi Muratani
Niantao Deng
Patrick Tan
Research10 Jul 2014
Nature Communications

Volume: 5, P: 1-14
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

Fernando Rivadeneira and colleagues in the Genetic Factors for Osteoporosis Consortium report a large-scale meta-analysis identifying new loci associated with bone mineral density (BMD) and risk of fracture. Thirty-two new loci are found to be associated with BMD, and 6 loci confer higher risk for low-trauma bone fracture.

Karol Estrada
Unnur Styrkarsdottir
Fernando Rivadeneira
Research15 Apr 2012
Nature Genetics

Volume: 44, P: 491-501
Gestational age-specific normative values and determinants of serum progesterone through the first trimester of pregnancy

Chee Wai Ku
Xiaoxuan Zhang
Thiam Chye Tan
ResearchOpen Access18 Feb 2021
Scientific Reports

Volume: 11, P: 1-8
An open-source platform for analyzing and sharing worm-behavior data

Avelino Javer
Michael Currie
André E. X. Brown
Correspondence31 Aug 2018
Nature Methods

Volume: 15, P: 645-646
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

COVID-19 can be associated with neurological complications. Here the authors show that markers of brain injury, but not immune markers, are elevated in the blood of patients with COVID-19 both early and months after SARS-CoV-2 infection, particularly in those with brain dysfunction or neurological diagnoses.

Benedict D. Michael
Cordelia Dunai
David K. Menon
ResearchOpen Access22 Dec 2023
Nature Communications

Volume: 14, P: 1-15
Risk score to stratify miscarriage risk levels in preconception women

Xin Hui Choo
Chee Wai Ku
Jerry Kok Yen Chan
ResearchOpen Access08 Jun 2021
Scientific Reports

Volume: 11, P: 1-11
Characterisation of serum progesterone and progesterone-induced blocking factor (PIBF) levels across trimesters in healthy pregnant women

Mark Kit Lim
Chee Wai Ku
Nguan Soon Tan
ResearchOpen Access02 Mar 2020
Scientific Reports

Volume: 10, P: 1-9
Distribution and association of interpregnancy weight change with subsequent pregnancy outcomes in Asian women

Chee Wai Ku
Tuck Seng Cheng
See Ling Loy
ResearchOpen Access24 Mar 2023
Scientific Reports

Volume: 13, P: 1-10
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
Insight into different environmental niches adaptation and allergenicity from the Cladosporium sphaerospermum genome, a common human allergy-eliciting Dothideomycetes

Su Mei Yew
Chai Ling Chan
Chee Sian Kuan
ResearchOpen Access31 May 2016
Scientific Reports

Volume: 6, P: 1-13
Evaluation of subconjunctival liposomal steroids for the treatment of experimental uveitis

Chee Wai Wong
Bertrand Czarny
Tina T. Wong
ResearchOpen Access26 Apr 2018
Scientific Reports

Volume: 8, P: 1-11
Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

Benedict D. Michael
Cordelia Dunai
David K. Menon
Amendments and CorrectionsOpen Access04 Apr 2024
Nature Communications

Volume: 15, P: 1
Identification and characterization of a novel Epstein-Barr Virus-encoded circular RNA from LMP-2 Gene

Ke-En Tan
Wei Lun Ng
Yat-Yuen Lim
ResearchOpen Access13 Jul 2021
Scientific Reports

Volume: 11, P: 1-15
The fetal mouse metatarsal bone explant as a model of angiogenesis

This protocol describes how to set up an assay investigating vessel outgrowth from mouse fetal metatarsals. This assay is an ex vivo assay to investigate sprouting angiogenesis.

Weihua Song
Chee Wai Fhu
Xiaomeng Wang
Protocols03 Sept 2015
Nature Protocols

Volume: 10, P: 1459-1473
Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer

Using single-cell RNA sequencing, Dong, Miao, Wang et al. profile the transcriptomes of 21,292 cells from biopsies of 6 castration-resistant prostate cancers. They find that all neuroendocrine tumor cells display a luminal-like epithelial phenotype, providing insights into the cellular states underlying neuroendocrine transdifferentiation in human prostate cancer.

Baijun Dong
Juju Miao
Wei-Qiang Gao
ResearchOpen Access16 Dec 2020
Communications Biology

Volume: 3, P: 1-15
Developing a lifestyle intervention program for overweight or obese preconception, pregnant and postpartum women using qualitative methods

Chee Wai Ku
Shu Hui Leow
See Ling Loy
ResearchOpen Access15 Feb 2022
Scientific Reports

Volume: 12, P: 1-9
Correlation of axial length and myopic macular degeneration to levels of molecular factors in the aqueous

Chee Wai Wong
Yasuo Yanagi
Chui Ming Gemmy Cheung
ResearchOpen Access31 Oct 2019
Scientific Reports

Volume: 9, P: 1-8
Type II collagen scaffolds for tissue engineering

Type II collagen, a key component of cartilaginous tissue, provides mechanical strength, supports cell growth, and regulates cellular processes. This Review covers the applications and advancements of type II collagen scaffolds in tissue engineering, focusing on hyaline cartilage and fibrocartilage.

Xu Hu
Zhonglian Wu
Dong-An Wang
ReviewsOpen Access10 Aug 2024
Communications Materials

Volume: 5, P: 1-17
Global Assessment of Retinal Arteriolar, Venular and Capillary Microcirculations Using Fundus Photographs and Optical Coherence Tomography Angiography in Diabetic Retinopathy

Tien-En Tan
Quang Nguyen
Daniel Shu Wei Ting
ResearchOpen Access13 Aug 2019
Scientific Reports

Volume: 9, P: 1-9
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22

Search

Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose

Untargeted metabolomics reveals key pathways in miscarriage: steroid, folate, fatty acid & glycosaminoglycan metabolism

Mapping the human genetic architecture of COVID-19

Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity

SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients

Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19

25-years Trends and Risk factors related to Surgical Outcomes of Giant Retinal Tear-Rhegmatogenous Retinal Detachments

Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing

Genomic landscape of lung adenocarcinoma in East Asians

Novel approach using serum progesterone as a triage to guide management of patients with threatened miscarriage: a prospective cohort study

A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma

Anti-retinal autoantibodies in myopic macular degeneration: a pilot study

Nanoscale chromatin profiling of gastric adenocarcinoma reveals cancer-associated cryptic promoters and somatically acquired regulatory elements

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

Gestational age-specific normative values and determinants of serum progesterone through the first trimester of pregnancy

An open-source platform for analyzing and sharing worm-behavior data

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

Risk score to stratify miscarriage risk levels in preconception women

Characterisation of serum progesterone and progesterone-induced blocking factor (PIBF) levels across trimesters in healthy pregnant women

Distribution and association of interpregnancy weight change with subsequent pregnancy outcomes in Asian women

At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Insight into different environmental niches adaptation and allergenicity from the Cladosporium sphaerospermum genome, a common human allergy-eliciting Dothideomycetes

Evaluation of subconjunctival liposomal steroids for the treatment of experimental uveitis

Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

Identification and characterization of a novel Epstein-Barr Virus-encoded circular RNA from LMP-2 Gene

The fetal mouse metatarsal bone explant as a model of angiogenesis

Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer

Developing a lifestyle intervention program for overweight or obese preconception, pregnant and postpartum women using qualitative methods

Correlation of axial length and myopic macular degeneration to levels of molecular factors in the aqueous

Type II collagen scaffolds for tissue engineering

Global Assessment of Retinal Arteriolar, Venular and Capillary Microcirculations Using Fundus Photographs and Optical Coherence Tomography Angiography in Diabetic Retinopathy

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

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