Deleted in liver cancer 1 (DLC1) is frequently down-regulated in hepatocellular carcinoma tissue and correlates with α-fetoprotein levels, vascular invasion, poor differentiation and poor prognosis. The authors show that DLC1 suppresses the proliferation, migration, invasion and autophagy of hepatocellular carcinoma cells through inactivating Wnt/β-catenin signaling and inhibition of the serine/threonine kinase ROCK1.
- Hui-Ta Wu
- Cheng-Rong Xie
- Zhen-Yu Yin
