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Showing 1–3 of 3 results
Advanced filters: Author: Chinmai Pindi Clear advanced filters

  • Pindi and Palermo review the contributions of deep learning structure prediction algorithms, physics-based simulations, neural networks, graph neural networks and generative models in engineering CRISPR systems and in understanding their mechanistic basis.

    • Chinmai Pindi
    • Giulia Palermo
    Reviews
    Nature Structural & Molecular Biology
    Volume: 33, P: 203-214

  • CRISPR-Cas9 is a major gene-editing tool that has attracted tremendous interdisciplinary efforts to ameliorate precise genome manipulation. Now, the pivotal structural features behind concerted double-stranded DNA cleavages by the Cas9 endonuclease have been captured through cryo-electron microscopy, laying the groundwork for improved Cas9 engineering.

    • Aakash Saha
    • Chinmai Pindi
    • Giulia Palermo
    News & Views
    Nature Catalysis
    Volume: 6, P: 870-872