In this Review, Hoppe and Elger discuss the etiological factors underlying depression as a comorbidity of epilepsy, comprising psychological factors such as learned helplessness and the 'burden of epilepsy', and neurobiological factors directly related to the seizures. The authors highlight the need for more clinical studies of antidepressants and psychotherapy, and emphasize the importance of an integrated approach to treatment that addresses both the psychological and the neurobiological factors.
- Christian Hoppe
- Christian E. Elger
