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Showing 351–400 of 592 results

Advanced filters: Author: Christian I. Hong Clear advanced filters

Polluted dust promotes new particle formation and growth

Wei Nie
Aijun Ding
Markku Kulmala
ResearchOpen Access16 Oct 2014
Scientific Reports

Volume: 4, P: 1-7
Age at onset of type 1 diabetes between puberty and 30 years old is associated with increased diabetic nephropathy risk

Yen-Bo Lin
Wayne Huey-Herng Sheu
Tien-Jyun Chang
ResearchOpen Access13 Feb 2024
Scientific Reports

Volume: 14, P: 1-11
NTRK1 Fusions identified by non-invasive plasma next-generation sequencing (NGS) across 9 cancer types

Christian Rolfo
Alexander Drilon
David R. Gandara
Research03 Sept 2021
British Journal of Cancer

Volume: 126, P: 514-520
Epigenomics and transcriptomics association study of blood pressure and incident diagnosis of hypertension in twins

We identified biological pathways related to vascular smooth muscle cells and the immune system, particular inflammation, to be associated with hypertension and blood pressure. Of specific genes, we identified KMT2A (lysine methyltransferase 2A) to be central for blood pressure and hypertension development. Abbreviations: ACTB: beta-actin, ATM: ataxia-telangiectasia mutated, BP: blood pressure, EWAS: epigenome-wide association studies, KMT2A: lysine methyltransferase 2A, LMER: linear mixed effect regression, LR: linear regression, TWAS: transcriptome-wide association studies.

Asmus Cosmos Skovgaard
Afsaneh M. Nejad
Mette Soerensen
ResearchOpen Access19 Feb 2025
Hypertension Research

Volume: 48, P: 1599-1612
Estimation bias and agreement limits between two common self-report methods of habitual sleep duration in epidemiological surveys

Maria Korman
Daria Zarina
Cátia Reis
ResearchOpen Access10 Feb 2024
Scientific Reports

Volume: 14, P: 1-11
Children with chronic myeloid leukaemia treated with front-line imatinib have a slower molecular response and comparable survival compared with adults: a multicenter experience in Taiwan

Hsi-Che Liu
Ming-Chung Kuo
Lee-Yung Shih
Research30 Jan 2023
British Journal of Cancer

Volume: 128, P: 1294-1300
Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN)

The Dominantly Inherited Alzheimer Network neuroimaging repository is a free resource consisting of PET and MRI scans from 533 individuals across 206 families who are deeply phenotyped with genetic, clinical, cognitive and biofluid sampling.

Nicole S. McKay
Brian A. Gordon
Christian la Fougère
ResearchOpen Access10 Jul 2023
Nature Neuroscience

Volume: 26, P: 1449-1460
Author Correction: Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals

Nicola Whiffin
Konrad J. Karczewski
James S. Ware
Amendments and CorrectionsOpen Access02 Feb 2021
Nature Communications

Volume: 12, P: 1
Genomic variation in 3,010 diverse accessions of Asian cultivated rice

Analyses of genetic variation and population structure based on over 3,000 cultivated rice (Oryza sativa) genomes reveal subpopulations that correlate with geographic location and patterns of introgression consistent with multiple rice domestication events.

Wensheng Wang
Ramil Mauleon
Hei Leung
ResearchOpen Access25 Apr 2018
Nature

Volume: 557, P: 43-49
Benchmarking the reproducibility of all-solid-state battery cell performance

More transparent protocol reporting and comprehensive battery cell data are needed. Twenty-one research groups joined forces to assess solid-state battery performance and found considerable differences in assembly protocols that cause variable results.

Sebastian Puls
Elina Nazmutdinova
Nella M. Vargas-Barbosa
ResearchOpen Access18 Sept 2024
Nature Energy

Volume: 9, P: 1310-1320
PI3Kδ and PI3Kγ: partners in crime in inflammation in rheumatoid arthritis and beyond?

The phosphoinositide 3-kinase (PI3K) isoforms PI3Kδ and PI3Kγ generate lipid second messengers that control an array of signalling pathways for numerous immune-cell functions. Recent studies indicate that specific targeting of these PI3K isoforms could be beneficial for treating inflammatory diseases.

Christian Rommel
Montserrat Camps
Hong Ji
Reviews09 Feb 2007
Nature Reviews Immunology

Volume: 7, P: 191-201
Association between FDG- and TSPO-PET signals across human and animal studies investigating neurodegenerative conditions: a systematic review

Luiza S. Machado
Pedro Vidor
Eduardo R. Zimmer
Reviews04 Sept 2025
Molecular Psychiatry

P: 1-17
A high sucrose detection threshold is associated with increased energy intake and improved post-prandial glucose response independent of the sweetness intensity of isocaloric sucrose solutions

Verena Preinfalk
Kerstin Schweiger
Barbara Lieder
ResearchOpen Access29 Jan 2024
npj Metabolic Health and Disease

Volume: 2, P: 1-11
The predictive ability of the 313 variant–based polygenic risk score for contralateral breast cancer risk prediction in women of European ancestry with a heterozygous BRCA1 or BRCA2 pathogenic variant

Inge M. M. Lakeman
Alexandra J. van den Broek
Marjanka K. Schmidt
ResearchOpen Access10 Jun 2021
Genetics in Medicine

Volume: 23, P: 1726-1737
Temporal trends in sex differences in dementia care—results from the Swedish registry for cognitive/dementia disorders, SveDem

Tamar Abzhandadze
Minh Tuan Hoang
Sara Garcia-Ptacek
ResearchOpen Access29 May 2025
Scientific Reports

Volume: 15, P: 1-11
Spectral control of nonclassical light pulses using an integrated thin-film lithium niobate modulator

An integrated thin-film lithium niobate phase modulator enables on-chip frequency and bandwidth control of single photons

Di Zhu
Changchen Chen
Marko Lončar
ResearchOpen Access17 Nov 2022
Light: Science & Applications

Volume: 11, P: 1-9
Analyzing spatio-temporal dynamics of dissolved oxygen for the River Thames using superstatistical methods and machine learning

Hankun He
Takuya Boehringer
Christian Beck
ResearchOpen Access12 Sept 2024
Scientific Reports

Volume: 14, P: 1-17
Copy number variants as modifiers of breast cancer risk for BRCA1/BRCA2 pathogenic variant carriers

The risk of germline copy number variants (CNVs) in BRCA1 and BRCA2 pathogenic variant carriers in breast cancer is assessed, with CNVs overlapping SULT1A1 decreasing breast cancer risk in BRCA1 carriers.

Christopher Hakkaart
John F. Pearson
Logan C. Walker
ResearchOpen Access06 Oct 2022
Communications Biology

Volume: 5, P: 1-15
Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling

Leptin regulates energy balance. The authors show that Rho-kinase 1 (ROCK1) regulates leptin signaling by increasing activation of signaling molecules downstream of leptin receptor. Deletion of ROCK1 from POMC or AgRP neurons leads to obesity and reduced leptin sensitivity.

Hu Huang
Dong Kong
Young-Bum Kim
Research02 Sept 2012
Nature Neuroscience

Volume: 15, P: 1391-1398
TransPeakNet for solvent-aware 2D NMR prediction via multi-task pre-training and unsupervised learning

Accurate NMR shift prediction using machine learning allows researchers to validate structures by comparing predicted and observed shifts, but predicting 2D NMR remains challenging due to limited annotated data. Here, the authors introduce an unsupervised training framework for predicting and annotating cross-peaks in 2D NMR considering solvent effect, specifically Heteronuclear Single Quantum Coherence (HSQC), showing a MAE of 2.05 ppm for ¹³C and 0.165 ppm for ¹H, and achieving 95.21% concordance with experts’ assignments.

Yunrui Li
Hao Xu
Pengyu Hong
ResearchOpen Access20 Feb 2025
Communications Chemistry

Volume: 8, P: 1-10
Structural basis of Mcm2–7 replicative helicase loading by ORC–Cdc6 and Cdt1

A 3.9-Å-resolution cryo-EM structure of the S. cerevisiae OCCM replicative helicase loading complex bound to DNA shows how ORC and Cdc6 recognize DNA origins, and reveals details of how the Mcm2–7 hexamer ring is loaded onto the DNA helix.

Zuanning Yuan
Alberto Riera
Huilin Li
Research13 Feb 2017
Nature Structural & Molecular Biology

Volume: 24, P: 316-324
Determining regional brain growth in premature and mature infants in relation to age at MRI using deep neural networks

Farzad Beizaee
Michele Bona
Gregory Lodygensky
ResearchOpen Access15 Aug 2023
Scientific Reports

Volume: 13, P: 1-11
Common pitfalls and recommendations for using machine learning to detect and prognosticate for COVID-19 using chest radiographs and CT scans

Many machine learning-based approaches have been developed for the prognosis and diagnosis of COVID-19 from medical images and this Analysis identifies over 2,200 relevant published papers and preprints in this area. After initial screening, 62 studies are analysed and the authors find they all have methodological flaws standing in the way of clinical utility. The authors have several recommendations to address these issues.

Michael Roberts
Derek Driggs
Carola-Bibiane Schönlieb
ResearchOpen Access15 Mar 2021
Nature Machine Intelligence

Volume: 3, P: 199-217
Broadband electro-optic frequency comb generation in a lithium niobate microring resonator

Using a thin-film lithium niobate photonic platform, an electro-optic frequency comb generator is realized that is capable of producing wide and stable spectra, spanning more frequencies than the entire telecommunications L-band.

Mian Zhang
Brandon Buscaino
Marko Lončar
Research11 Mar 2019
Nature

Volume: 568, P: 373-377
Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors

Proteins expressed on the surfaces of erythrocytes infected with Plasmodium falciparum help the parasite to evade the host immune system by acting as ligands for immune inhibitory receptors and thereby downregulating the immune response.

Fumiji Saito
Kouyuki Hirayasu
Hisashi Arase
Research29 Nov 2017
Nature

Volume: 552, P: 101-105
Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants

Daniel R. Barnes
Matti A. Rookus
Antonis C. Antoniou
ResearchOpen Access15 Jul 2020
Genetics in Medicine

Volume: 22, P: 1653-1666
Establishing bio-logging data collections as dynamic archives of animal life on Earth

Animal-borne electronic tags, or bio-loggers, are increasingly used for research and wildlife conservation. This Perspective discusses the importance of standardization, long-term archiving and sharing of bio-logging data, and outlines a roadmap to achieve these goals.

Sarah C. Davidson
Francesca Cagnacci
Christian Rutz
Reviews03 Jan 2025
Nature Ecology & Evolution

Volume: 9, P: 204-213
Modeling surge dynamics improves coastal flood estimates in a global set of tropical cyclones

Accounting for inundation processes dynamically improves the modeling of tropical cyclone-induced coastal flooding compared to state-of-the-art, globally applicable approaches using static bathtub-type inundation models.

Thomas Vogt
Simon Treu
Christian Otto
ResearchOpen Access27 Sept 2024
Communications Earth & Environment

Volume: 5, P: 1-19
ESG performance on the value of family firms: international evidence during Covid-19

Christian Espinosa-Méndez
Carlos Maquieira
José Tomás Arias
ResearchOpen Access08 May 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-9
The Efficacy and Cost-Effectiveness of Stepped Care Prevention and Treatment for Depressive and/or Anxiety Disorders: A Systematic Review and Meta-Analysis

Fiona Yan-Yee Ho
Wing-Fai Yeung
Christian S. Chan
ResearchOpen Access05 Jul 2016
Scientific Reports

Volume: 6, P: 1-10
Comparing SARS-CoV-2 antigen-detection rapid diagnostic tests for COVID-19 self-testing/self-sampling with molecular and professional-use tests: a systematic review and meta-analysis

Stephan Katzenschlager
Lukas E. Brümmer
Seda Yerlikaya
ResearchOpen Access11 Dec 2023
Scientific Reports

Volume: 13, P: 1-15
Author Correction: A structural variation reference for medical and population genetics

Ryan L. Collins
Harrison Brand
Michael E. Talkowski
Amendments and CorrectionsOpen Access03 Feb 2021
Nature

Volume: 590, P: E55
High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

John Rioux, Andre Franke, Tom Karlsen and colleagues perform a fine-mapping study of the HLA region in Crohn's disease and ulcerative colitis. They identify a primary role for HLA-DRB1*01:03 in both diseases and find evidence of heterozygous advantage in protection against ulcerative colitis.

Philippe Goyette
Gabrielle Boucher
John D Rioux
Research05 Jan 2015
Nature Genetics

Volume: 47, P: 172-179
Can early diastolic velocity of the mitral annulus predict survival in patients with impaired left-ventricular function?

Christian Bruch
Comments & Opinion01 Aug 2005
Nature Clinical Practice Cardiovascular Medicine

Volume: 2, P: 388-389
A gravitational-wave standard siren measurement of the Hubble constant

The astronomical event GW170817, detected in gravitational and electromagnetic waves, is used to determine the expansion rate of the Universe, which is consistent with and independent of existing measurements.

B. P. Abbott
R. Abbott
M. Serra-Ricart
Research16 Oct 2017
Nature

Volume: 551, P: 85-88
The LRRK2 p.L1795F variant causes Parkinson’s disease in the European population

Lara M. Lange
Kristin Levine
Masharip Atadzhanov
ResearchOpen Access25 Mar 2025
npj Parkinson's Disease

Volume: 11, P: 1-10
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

An integrated analysis of over 100 single-cell and single-nucleus transcriptomics studies illustrates severe acute respiratory syndrome coronavirus 2 viral entry gene coexpression patterns across different human tissues, and shows association of age, smoking status and sex with viral entry gene expression in respiratory cell populations.

Christoph Muus
Malte D. Luecken
Xiaohui Zhang
Research02 Mar 2021
Nature Medicine

Volume: 27, P: 546-559
Differential prognostic values of the three AKT isoforms in acute myeloid leukemia

Eulalie Corre
Cécile Soum
Stéphane Pyronnet
ResearchOpen Access25 Mar 2024
Scientific Reports

Volume: 14, P: 1-12
Author Correction: The effect of LRRK2 loss-of-function variants in humans

Nicola Whiffin
Irina M. Armean
Daniel G. MacArthur
Amendments and Corrections22 Jan 2021
Nature Medicine

Volume: 27, P: 355
Author Correction: The mutational constraint spectrum quantified from variation in 141,456 humans

Konrad J. Karczewski
Laurent C. Francioli
Daniel G. MacArthur
Amendments and CorrectionsOpen Access03 Feb 2021
Nature

Volume: 590, P: E53
Author Correction: Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes

Qingbo Wang
Emma Pierce-Hoffman
Daniel G. MacArthur
Amendments and CorrectionsOpen Access02 Feb 2021
Nature Communications

Volume: 12, P: 1
Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

A large-scale epigenome-wide association study identifies changes in DNA methylation associated with body mass index in blood and adipose tissue, and correlates DNA methylation sites with high risk of incident type 2 diabetes.

Simone Wahl
Alexander Drong
John C. Chambers
Research21 Dec 2016
Nature

Volume: 541, P: 81-86
Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

Laura M. Huckins
Amanda Dobbyn
Eli A. Stahl
Amendments and Corrections13 May 2019
Nature Genetics

Volume: 51, P: 1068
Impact of genetic variants on major bleeding after percutaneous coronary intervention based on a prospective multicenter registry

Jung-Joon Cha
Hyung Joon Joo
Do-Sun Lim
ResearchOpen Access19 Jan 2021
Scientific Reports

Volume: 11, P: 1-8
Publisher Correction: Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes

Jennifer L. Halford
Valerie N. Morrill
Steven A. Lubitz
Amendments and CorrectionsOpen Access30 Sept 2022
Nature Communications

Volume: 13, P: 1
Vascular endothelial growth factor: a neurovascular target in neurological diseases

The archetypal vascular endothelial growth factor, VEGF, arose in evolution as a signal affecting neural cells, and was subsequently co-opted to regulate vascular function. Here, the authors review the roles of the VEGF family as both aetiological factors and therapeutic targets in neurological disease.

Christian Lange
Erik Storkebaum
Peter Carmeliet
Reviews01 Jul 2016
Nature Reviews Neurology

Volume: 12, P: 439-454
The International Climate Psychology Collaboration: Climate change-related data collected from 63 countries

Kimberly C. Doell
Boryana Todorova
Jay J. Van Bavel
ResearchOpen Access01 Oct 2024
Scientific Data

Volume: 11, P: 1-17
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

Stephen Sawcer
Garrett Hellenthal
Alastair Compston
Research10 Aug 2011
Nature

Volume: 476, P: 214-219
Personalized structural image analysis in patients with temporal lobe epilepsy

Christian Rummel
Nedelina Slavova
Roland Wiest
ResearchOpen Access07 Sept 2017
Scientific Reports

Volume: 7, P: 1-12
Transcriptome dynamics of CD4⁺ T cells during malaria maps gradual transit from effector to memory

CD4⁺ T cells are critical for effective responses to infection with the malaria parasite. Haque and colleagues use single-cell RNA sequencing and computational modeling to track T cell memory development during experimental Plasmodium infection of mice.

Megan S. F. Soon
Hyun Jae Lee
Ashraful Haque
Research12 Oct 2020
Nature Immunology

Volume: 21, P: 1597-1610

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