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Ultrafast shaping of exciton-polariton condensates enables applications for classical and quantum logic devices and provides insights into the physics of nonequilibrium quantum condensates in solid-state. Here, the authors demonstrate ultrafast and reversible dynamic Stark modulation of a semiconductor exciton-polariton quantum condensate.

Optically trapped CaOH molecules in parity-doublet states achieve coherence times exceeding vibrational lifetimes, which are a defining milestone for the use of polyatomic molecules in quantum science.

Realising scalable entangled photon sources with quantum dots requires compensating for both wavelength mismatches and exciton fine-structure splitting (FSS). So far, multiple QDs with the same emission wavelength and near-zero FSS have not been demonstrated. Here, the authors fill this gap, reaching high entanglement fidelity for multiple QDs tuned into resonance with each other or with Rb atoms.

Building scalable quantum technologies requires generating robust many-body entanglement in solid-state platforms. This Review highlights how engineered light–matter interactions, optical nonlinearities and coupling to nanophotonic structures enable coherent many-body entangled states that are resilient to disorder and decoherence.

This paper uses multiomics to profile a large cohort of meningioma samples to highlight the role of the tumor microenvironment in driving the epigenetic changes underpinning tumor classification and prediction of outcome.

Approved antibody–drug conjugates (ADCs) remain constrained by a limited repertoire of payloads with restricted modes of action. Here, the authors present phosphoramidate-based self-immolative linker units that facilitate stable attachment in serum and traceless drug release in the target cell from aliphatic and aromatic alcohols with various modes of action.

The spatial structure of vortex laser beams associates angular momentum to photons, which, in addition to their spin, can be used to tailor light-matter interactions. Here, the authors excite an atomic transition with a vortex laser beam, showing that the transfer of angular momentum modifies selection rules.

Qutrits, or quantum three-level systems, can provide advantages over qubits in certain quantum information applications, and high-fidelity single-qutrit gates have been demonstrated. Goss et al. realize high-fidelity entangling gates between two superconducting qutrits that are universal for ternary computation.

Magneto-optical traps (MOTs) are a workhorse for laser cooling of atoms and were recently extended to molecules. Yet, new mechanisms for molecular trapping and cooling are still an open area of exploration. Here, the authors show a blue-detuned MOT based on a conveyor-belt effect for CaF molecules, yielding higher number densities, comparable with some atomic MOTs.

An 11-qubit atom processor comprising two precision-placed nuclear spin registers of phosphorus in silicon is shown to achieve state-of-the-art Bell-state fidelities of up to 99.5%.

Laser-induced tuning of pairs of lifetime-limited organic emitters allows the controlled creation of superradiant and subradiant entangled states.

This work investigates changes in regularity of crop failure, heatwave and wildfire exposure for different future climate scenarios. Major shifts in dominant periods are observed when moving from pre-industrial to current climate conditions.

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

Yong et al. highlight how sampling conditions affect metabolic profile in renal cancer, showing that prolonged ischemic exposure disrupts tissue metabolome stability and masks important phenotypes, such as suppressed gluconeogenesis.

New research finds that policymakers coleading energy scenario design has the potential both to better align scenarios with policymakers’ priorities and to question current policy, by substantially reducing energy use at half of the cost of technology-focused approaches.

Authors combine neutron scattering and MD simulations to study psychrophilic bacteria, linking proteome dynamics to the state of the proteome folding in the context of differential thermal adaptation.

An optical tweezer array of individual polyatomic molecules is created, revealing the obvious state control in the tweezer array and enabling further research on polyatomic molecules with diverse spatial arrangements.

Current photoproximity labelling methods often require metal-based catalysts to map protein interactomes but, owing to their toxicity, they have limited intracellular applicability. A deazaflavin cofactor has now been developed as a biocompatible alternative for diazirine activation inside living cells, offering accurate mapping of protein interactors and dynamics with excellent spatio-temporal control.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Pathogenic variants in UNC13A underlie a novel neurodevelopmental syndrome, with three subtypes defined by distinct genotypes with varying clinical and functional impacts characterized in cellular and animal models.

The author demonstrates that laser-driven ultracold Fermi gases can exhibit color-orbit-like coupling with SU(3) symmetry. This leads to color-like oscillations and other quantum-chromodyamics-like phenomena in an atomic physics laboratory.

Mass-wasting deposits that accumulated against mid-ocean ridge faults have high porosity in which calcium carbonate precipitated, storing seawater carbon dioxide, as revealed by cores of a 61-million-year-old seafloor talus deposit.

Two types of on-chip silicon device utilizing silicon T centres are developed: an O-band light-emitting diode and an electrically triggered single-photon source. Further, a new method of spin initialization with electrical excitation is demonstrated.

Cancer immunotherapy benefits from antibody-lectin chimeras that block glyco-immune checkpoints.

Fluctuations of the electrical current in nanoscale devices reveal important details of the physical processes occurring inside them. Using a quantum point contact placed in its vicinity, Ubbelohde et al. measure the electrical fluctuations in a single-electron transistor, and determine the dynamical features of the transport.

Despite their differences, the rarer sarcoma CIC::DUX4 sarcoma (CDS) is typically treated with therapies developed for Ewing Sarcoma (EwS) with limited success. Here, the authors develop a co-clinical drug response profiling platform to establish patient-derived CDS and EwS tumoroids, identifying MCL1 inhibition as a promising therapeutic approach in CDS.

Reconfigurable arrays of up to 448 neutral atoms are used to implement and combine the key elements of a universal, fault-tolerant quantum processing architecture and experimentally explore their underlying working mechanisms.

The limited routes for polar texture engineering in materials restrict energy efficient applications. Here, the authors establish lattice chemistry control and the use of polarizing surfaces to manipulate electric dipole ordering in thin films.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

The DNA-dependent protease SPRTN cleaves toxic DNA-protein crosslinks (DPCs). Here, the authors show that SPRTN is activated by DPC-ubiquitylation through an allosteric ubiquitin binding interface. This regulatory mechanism enables precise control of SPRTN activity during DNA repair.

One of the challenges in maintaining quantum coherence in semiconductor devices is coping with the fluctuating magnetic field generated by nearby nuclear spins. Here the authors explore the functioning of a feedback mechanism between electron and nuclear spins that extends the coherence time of a many-electron quantum dot.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

Diamond colour centres are of interest for solid-state quantum technologies but obtaining an efficient spin-photon interface remains challenging. Here, the authors use resonant excitation under magnetic fields to optically access the electronic spin sublevels of silicon-vacancy centres in diamond.

The effect of temperature on charge transport mechanisms in molecular tunnel junctions is not fully understood. Here, charge transport studies of a redox-active molecule unveil multiple mechanistic regimes which may be explained by thermal broadening of the Fermi distributions of electrons in the leads.

Thanks to their strong light-matter interaction, atomically thin transition metal dichalcogenides are ideal active materials for cavity quantum electrodynamics. Here, the authors embed a WSe₂monolayer within a Tamm-plasmon-polariton cavity, and observe exciton-polariton formation at room temperature.

Experimental measurements of high-order out-of-time-order correlators on a superconducting quantum processor show that these correlators remain highly sensitive to the quantum many-body dynamics in quantum computers at long timescales.

By coupling plasmonic resonators with a semiconductor heterostructure, researchers control the nonlinear response by a bias voltage, thereby enabling spectral tuning, dynamic intensity modulation and dynamic beam manipulation for second-harmonic generation.

A high-resolution three-dimensional endoscopic imaging technique resolves unique features in Barrett’s oesophageal neoplasia.

Ultracold alkaline-earth fermionic atoms with large number of nuclear spin states possess SU(N) symmetry. That deeply affects their interaction properties, and allows a Fermi gas of these atoms to be cooled quickly to the quantum degenerate regime.

Monoclonal antibodies and ligands targeting CD40 exhibit diverse agonistic and antitumor activities that are influenced by their design. Here, the authors identify mechanistic differences between clinically relevant anti-CD40 subclasses and CD40L, focusing on the dynamics and strengths of multi-bond formation at the single-molecule level.

Chiroptical sensing in complex mixtures remains a challenging task. Here, the authors report an efficient coumarin probe for chiroptical click chirality sensing of absolute configuration, concentration and enantiomeric excess of several compound classes. The method can be directly applied to crude asymmetric reaction mixtures.