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NLRP3 licenses NLRP11 for inflammasome activation in human macrophages

Stehlik and colleagues show that NLRP11 is an essential component of the NLRP3 inflammasome in human macrophages.

Anu Gangopadhyay
Savita Devi
Christian Stehlik
ResearchOpen Access27 May 2022
Nature Immunology

Volume: 23, P: 892-903
The PYRIN domain–only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses

Much is known about the activation of inflammasomes, but less is known about their negative regulation. Stehlik and colleagues demonstrate that the pyrin domain–only protein POP3 negatively regulates inflammasomes involved in sensing DNA.

Sonal Khare
Rojo A Ratsimandresy
Christian Stehlik
Research16 Feb 2014
Nature Immunology

Volume: 15, P: 343-353
The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation

Excessive inflammasome activation leads to inflammatory diseases, but how inflammasomes are regulated by PYD-only adaptors is unclear. Here the authors show that the PYD-only protein POP2 inhibits both inflammasome priming and assembly by interfering, respectively, with IκBα activation and NLRP3-ASC interaction.

Rojo A. Ratsimandresy
Lan H. Chu
Christian Stehlik
ResearchOpen Access05 Jun 2017
Nature Communications

Volume: 8, P: 1-15
The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages

Non-canonical inflammasome activation is mediated by caspase-11 in mice and caspase-4 in humans. Here the authors show that oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (oxPAPC) competes with LPS for binding to these caspases and in so doing is a negative regulator of non-canonical inflammasome activation in macrophages, but not in dendritic cells.

Lan H. Chu
Mohanalaxmi Indramohan
Christian Stehlik
ResearchOpen Access08 Mar 2018
Nature Communications

Volume: 9, P: 1-16
A dRAStic RHOAdblock of Pyrin inflammasome activation

The Pyrin inflammasome guard is disabled if the activity of small cellular GTPase is compromised in response to defects in the mevalonate pathway and is disabled directly by mutations in the gene encoding Pyrin, which results in the interleukin 1β (IL-1β)-driven autoinflammatory diseases MKD and FMF.

Andrea Dorfleutner
Christian Stehlik
News & Views19 Jul 2016
Nature Immunology

Volume: 17, P: 900-902
Peroxisomal core structures segregate diverse metabolic pathways

Peroxisomes contain detergent resistant core structures. Bäcker et al. show that these core structures contain diverse enzymes and serve to enable metabolic compartmentalization of the peroxisome lumen.

Nils Bäcker
Julia Ast
Johannes Freitag
ResearchOpen Access20 Feb 2025
Nature Communications

Volume: 16, P: 1-16
IκBα gene therapy in tumor necrosis factor-α- and chemotherapy-mediated apoptosis of hepatocellular carcinomas

Maja Katrin Tietze
Torsten Wuestefeld
Stefan Kubicka
Research01 Oct 2000
Cancer Gene Therapy

Volume: 7, P: 1315-1323
CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-κB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells

Anna Trauzold
Hendrik Wermann
Holger Kalthoff
Research17 Jul 2001
Oncogene

Volume: 20, P: 4258-4269
The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway

Rojo A Ratsimandresy
Mohanalaxmi Indramohan
Christian Stehlik
ResearchOpen Access15 Aug 2016
Cellular & Molecular Immunology

Volume: 14, P: 127-142

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