In keratinocytes, the multifunctional protein CLIC4 mediates TGF-β-dependent growth inhibition through interaction with Schnurri-2, which is essential for CLIC4 nuclear translocation. Once in the nucleus, CLIC4 associates with phospho-Smad2 and 3 and protects them from dephosphorylation by nuclear phosphatases.
- Anjali Shukla
- Mariam Malik
- Stuart H. Yuspa
