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Showing 51–100 of 111 results

Advanced filters: Author: Christopher Mathews Clear advanced filters

Non-coding variability at the APOE locus contributes to the Alzheimer’s risk

Several studies show that APOE-ε4 coding variants are associated with Alzheimer’s disease (AD) risk. Here, Zhou et al. perform fine-mapping of the APOE region and find AD risk haplotypes with non-coding variants in the PVRL2 and APOC1 regions that are associated with relevant endophenotypes.

Xiaopu Zhou
Yu Chen
Nancy Y. Ip
ResearchOpen Access25 Jul 2019
Nature Communications

Volume: 10, P: 1-16
Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

Progressive diseases tend to be heterogeneous in their underlying aetiology mechanism, disease manifestation, and disease time course. Here, Young and colleagues devise a computational method to account for both phenotypic heterogeneity and temporal heterogeneity, and demonstrate it using two neurodegenerative disease cohorts.

Alexandra L Young
Razvan V Marinescu
Ansgar J Furst
ResearchOpen Access15 Oct 2018
Nature Communications

Volume: 9, P: 1-16
Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

The tau protein is theorized to spread transneuronally in Alzheimers disease, though this theory remains unproven in humans. Our simulations of epidemic-like protein spreading across human brain networks support this theory, and suggest the spreading dynamics are modified by β-amyloid

Jacob W. Vogel
Yasser Iturria-Medina
Per Wollmer
ResearchOpen Access26 May 2020
Nature Communications

Volume: 11, P: 1-15
The DDB1–DCAF1–Vpr–UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destruction

The crystal structure of HIV-1 accessory protein Vpr in complex with human UNG2 and DDB1–DCAF1 provides insight into how the viral protein directs UNG2 for degradation.

Ying Wu
Xiaohong Zhou
Guillermo Calero
Research29 Aug 2016
Nature Structural & Molecular Biology

Volume: 23, P: 933-940
A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary trees of pigs and humans

Wencheng Zhang
Xicheng Wang
Lola McAdams Reid
ResearchOpen Access01 Aug 2023
npj Regenerative Medicine

Volume: 8, P: 1-20
Risk-adjusted colorectal cancer screening using the FIT and routine screening data: development of a risk prediction model

Jennifer Anne Cooper
Nick Parsons
Sian Taylor-Phillips
ResearchOpen Access02 Nov 2017
British Journal of Cancer

Volume: 118, P: 285-293
Deoxyribonucleotide metabolism, mutagenesis and cancer

This Review discusses nucleotide metabolism and how fluctuations in deoxyribonucleoside triphosphate (dNTP) pools affect genomic instability. Drugs that target this system have been in use for many years and some of these are discussed, as well as newer approaches to manipulating deoxyribonucleotide metabolism for cancer treatment.

Christopher K. Mathews
Reviews24 Aug 2015
Nature Reviews Cancer

Volume: 15, P: 528-539
Author Correction: Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

Sanjay Jain
Liming Pei
Michael P. Snyder
Amendments and Corrections01 Mar 2024
Nature Cell Biology

Volume: 26, P: 839
Author Correction: FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease

Tingxiang Yan
Jingjing Liang
Xinglong Wang
Amendments and CorrectionsOpen Access11 Jul 2022
Nature Communications

Volume: 13, P: 1-2
The impact of catch-up bivalent human papillomavirus vaccination on cervical screening outcomes: an observational study from the English HPV primary screening pilot

Matejka Rebolj
Francesca Pesola
Henry Kitchener
ResearchOpen Access26 Mar 2022
British Journal of Cancer

Volume: 127, P: 278-287
Population dynamics of threatened Lahontan cutthroat trout in Summit Lake, Nevada

James B. Simmons
Teresa Campbell
Kevin Shoemaker
ResearchOpen Access08 Jun 2020
Scientific Reports

Volume: 10, P: 1-11
Novel insights into the interaction of UBA5 with UFM1 via a UFM1-interacting sequence

Prasanth Padala
Walaa Oweis
Reuven Wiener
ResearchOpen Access30 Mar 2017
Scientific Reports

Volume: 7, P: 1-12
Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults

Simon M. Laws
Scott Gaskin
Giuseppe Verdile
ResearchOpen Access29 Aug 2017
Scientific Reports

Volume: 7, P: 1-11
Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome

Pritesh Jain
Tyne Miller-Fleming
Peristera Paschou
ResearchOpen Access23 Feb 2023
Translational Psychiatry

Volume: 13, P: 1-10
Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

The Human BioMolecular Atlas Program (HuBMAP) presents its production phase: the generation of spatial maps of functional tissue units across organs from diverse populations and the creation of tools and infrastructure to advance biomedical research.

Sanjay Jain
Liming Pei
Michael P. Snyder
Reviews19 Jul 2023
Nature Cell Biology

Volume: 25, P: 1089-1100
16/18 genotyping in triage of persistent human papillomavirus infections with negative cytology in the English cervical screening pilot

Matejka Rebolj
Adam R. Brentnall
Henry Kitchener
ResearchOpen Access14 Aug 2019
British Journal of Cancer

Volume: 121, P: 455-463
Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Research10 Jan 2022
Nature Medicine

Volume: 28, P: 53-58
Generative artificial intelligence performs rudimentary structural biology modeling

Alexander M. Ille
Christopher Markosian
Wadih Arap
ResearchOpen Access21 Aug 2024
Scientific Reports

Volume: 14, P: 1-10
Technology readiness and overcoming barriers to sustainably implement nanotechnology-enabled plant agriculture

Nanotechnology holds great application potential in plant agriculture. This Review Article identifies the technological readiness, addresses the primary barriers to adopting nano-enabled technologies and proposes a roadmap to advance nanotechnology-enabled agriculture.

Thilo Hofmann
Gregory Victor Lowry
Kevin James Wilkinson
Reviews16 Jul 2020
Nature Food

Volume: 1, P: 416-425
Single-cell proteomics enabled by next-generation sequencing or mass spectrometry

This Review covers the state of the art in applying mass spectrometry- or next-generation sequencing-based techniques for single-cell proteomics analysis, offering suggestions for maximizing the advantages of both approaches.

Hayley M. Bennett
William Stephenson
Spyros Darmanis
Reviews02 Mar 2023
Nature Methods

Volume: 20, P: 363-374
A predictive model using the mesoscopic architecture of the living brain to detect Alzheimer’s disease

Inglese et al. develop a predictive model that computes multi-regional statistical morpho-functional mesoscopic traits from T1-weighted magnetic resonance imaging scans. Their model reliably discriminates people with Alzheimer’s disease-related pathologies from those without.

Marianna Inglese
Neva Patel
Eric O. Aboagye
ResearchOpen Access20 Jun 2022
Communications Medicine

Volume: 2, P: 1-16
Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Amendments and CorrectionsOpen Access12 Jan 2022
Nature Medicine

Volume: 28, P: 212
Rapid generation of Col7a1^−/− mouse model of recessive dystrophic epidermolysis bullosa and partial rescue via immunosuppressive dermal mesenchymal stem cells

Beau R Webber
Kyle T O'Connor
Jakub Tolar
Research11 Sept 2017
Laboratory Investigation

Volume: 97, P: 1218-1224
Staging tau pathology with tau PET in Alzheimer’s disease: a longitudinal study

Shi-Dong Chen
Jia-Ying Lu
Michelle Zmuda
ResearchOpen Access18 Sept 2021
Translational Psychiatry

Volume: 11, P: 1-12
Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer’s amyloid, tau and FDG PET status

Xue-Ning Shen
Yu-Yuan Huang
Michelle Zmuda
ResearchOpen Access13 Nov 2021
Translational Psychiatry

Volume: 11, P: 1-10
Silicon ion radiation as a viable surrogate for emulating neutron radiation damage in silicates

Krishna C. Polavaram
Sai Kalyan Evani
Nishant Garg
ResearchOpen Access28 Aug 2024
npj Materials Degradation

Volume: 8, P: 1-14
Identifying healthy individuals with Alzheimer’s disease neuroimaging phenotypes in the UK Biobank

Azevedo et al. conduct a machine learning-based analysis of structural MRI data from multiple cohorts. The authors identify Alzheimer’s disease-like neuroimaging phenotypes associated with poorer cognitive performance in a healthy UK Biobank cohort, potentially highlighting a population at risk of Alzheimer’s disease.

Tiago Azevedo
Richard A. I. Bethlehem
Gail Li
ResearchOpen Access20 Jul 2023
Communications Medicine

Volume: 3, P: 1-15
Impact of changes to the interscreening interval and faecal immunochemical test threshold in the national bowel cancer screening programme in England: results from the FIT pilot study

Shuping J. Li
Tara Seedher
Stephen W. Duffy
ResearchOpen Access17 Aug 2022
British Journal of Cancer

Volume: 127, P: 1525-1533
Revealing the complex genetic architecture of obsessive–compulsive disorder using meta-analysis

Paul D Arnold
Kathleen D Askland
Gwyneth Zai
Research01 Aug 2017
Molecular Psychiatry

Volume: 23, P: 1181-1188
Identification of Small Molecule Enhancers of Immunotherapy for Melanoma

Christopher Dextras
Myagmarjav Dashnyam
Anju Singh
ResearchOpen Access30 Mar 2020
Scientific Reports

Volume: 10, P: 1-11
Author Correction: Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

Jacob W. Vogel
Yasser Iturria-Medina
Per Wollmer
Amendments and CorrectionsOpen Access05 Aug 2021
Nature Communications

Volume: 12, P: 1
Multiomics analysis to explore blood metabolite biomarkers in an Alzheimer’s Disease Neuroimaging Initiative cohort

Takaki Oka
Yuki Matsuzawa
Balebail Ashok Raj
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-14
DNA-damaging agents cause inactivation of translational regulators linked to mTOR signalling

Andrew R Tee
Christopher G Proud
Research19 Jun 2000
Oncogene

Volume: 19, P: 3021-3031
Enhanced physical and cognitive performance in active duty Airmen: evidence from a randomized multimodal physical fitness and nutritional intervention

Christopher E. Zwilling
Adam Strang
Aron K. Barbey
ResearchOpen Access19 Oct 2020
Scientific Reports

Volume: 10, P: 1-13
Correlation between Alzheimer’s disease and type 2 diabetes using non-negative matrix factorization

Yeonwoo Chung
Hyunju Lee
Kristin Fargher
ResearchOpen Access27 Jul 2021
Scientific Reports

Volume: 11, P: 1-14
Genome-wide association study of pediatric obsessive-compulsive traits: shared genetic risk between traits and disorder

Christie L. Burton
Mathieu Lemire
Paul D. Arnold
ResearchOpen Access02 Feb 2021
Translational Psychiatry

Volume: 11, P: 1-10
Multimodal Hippocampal Subfield Grading For Alzheimer’s Disease Classification

Kilian Hett
Vinh-Thong Ta
Kristin Fargher
ResearchOpen Access25 Sept 2019
Scientific Reports

Volume: 9, P: 1-16
Predicting Alzheimer’s disease progression using multi-modal deep learning approach

Garam Lee
Kwangsik Nho
Kristin Fargher
ResearchOpen Access13 Feb 2019
Scientific Reports

Volume: 9, P: 1-12
A telescope GWAS analysis strategy, based on SNPs-genes-pathways ensamble and on multivariate algorithms, to characterize late onset Alzheimer’s disease

Margherita Squillario
Giulia Abate
Kristin Fargher
ResearchOpen Access21 Jul 2020
Scientific Reports

Volume: 10, P: 1-12
Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics

Yogatheesan Varatharajah
Vijay K. Ramanan
Kristin Fargher
ResearchOpen Access19 Feb 2019
Scientific Reports

Volume: 9, P: 1-15
Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer’s Pathophysiology

Xinpeng Shen
Sisi Ma
Kristin Fargher
ResearchOpen Access19 Feb 2020
Scientific Reports

Volume: 10, P: 1-12
Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits

Yuetiva Deming
Jian Xia
Carlos Cruchaga
ResearchOpen Access04 Jan 2016
Scientific Reports

Volume: 6, P: 1-17
Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty

Lei Du
Kefei Liu
Kristin Fargher
ResearchOpen Access25 Oct 2017
Scientific Reports

Volume: 7, P: 1-14
A semi-mechanism approach based on MRI and proteomics for prediction of conversion from mild cognitive impairment to Alzheimer’s disease

Haochen Liu
Xiaoting Zhou
Kristin Fargher
ResearchOpen Access07 Jun 2016
Scientific Reports

Volume: 6, P: 1-12
Deep learning-based polygenic risk analysis for Alzheimer’s disease prediction

Zhou et al. utilise deep learning to improve polygenic risk analysis for Alzheimer’s disease. Their computational approach outperforms existing statistical methods and helps to identify potential biological mechanisms of Alzheimer’s disease risk.

Xiaopu Zhou
Yu Chen
Nancy Y. Ip
ResearchOpen Access06 Apr 2023
Communications Medicine

Volume: 3, P: 1-20
The trend of disruption in the functional brain network topology of Alzheimer’s disease

Alireza Fathian
Yousef Jamali
Ansgar J. Furst
ResearchOpen Access02 Sept 2022
Scientific Reports

Volume: 12, P: 1-17
Multimodal and Multiscale Deep Neural Networks for the Early Diagnosis of Alzheimer’s Disease using structural MR and FDG-PET images

Donghuan Lu
Karteek Popuri
Kristin Fargher
ResearchOpen Access09 Apr 2018
Scientific Reports

Volume: 8, P: 1-13
Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states

Ines Mahjoub
Mohamed Ali Mahjoub
Kristin Fargher
ResearchOpen Access07 Mar 2018
Scientific Reports

Volume: 8, P: 1-14
A blood-based signature of cerebrospinal fluid Aβ_1–42 status

Benjamin Goudey
Bowen J. Fung
Brenda Plassman
ResearchOpen Access11 Mar 2019
Scientific Reports

Volume: 9, P: 1-12
Characteristic patterns of inter- and intra-hemispheric metabolic connectivity in patients with stable and progressive mild cognitive impairment and Alzheimer’s disease

Sheng-Yao Huang
Jung-Lung Hsu
Balebail Ashok Raj
ResearchOpen Access14 Sept 2018
Scientific Reports

Volume: 8, P: 1-11

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