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Showing 1–2 of 2 results
Advanced filters: Author: Chun-Bing Chen Clear advanced filters

  • As immune checkpoint therapy is more frequently used for cancer, side effects such as Stevens-Johson syndrome / toxic epidermal necrolysis (SJS/TEN) are becoming more common. Here the authors use single cell transcriptomics to implicate TNF and CXCL10 in recruitment of CXCR3+ cytotoxic T cell in SJS/TEN skin lesions.

    • Chun-Bing Chen
    • Shuen-Iu Hung
    • Wen-Hung Chung
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • Severe cutaneous adverse reactions (SCAR) is a T cell-mediated, potentially lethal drug hypersensitivity (DH). Here, the authors identify a carbamazepine-specific TCR common among patients with carbamazepine-induced SCAR that confers SCAR-like pathology in mice upon carbamazepine exposure, thereby implicating specific TCRs in DH etiology.

    • Ren-You Pan
    • Mu-Tzu Chu
    • Shuen-Iu Hung
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13