Nature Search

Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer’s disease

Caloric restriction improves Alzheimer’s Disease outcomes in mice, but this diet not only reduces calories, but imposes a prolonged fast between meals. Here, the authors show this fast is essential to improve Alzheimer’s pathology and cognition.

Reji Babygirija
Jessica H. Han
Dudley W. Lamming
ResearchOpen Access04 Aug 2025
Nature Communications

Volume: 16, P: 1-20
Late-life protein or isoleucine restriction impacts physiological and molecular signatures of aging

Yeh et al. explore the effects of restricting dietary protein, or isoleucine specifically, in aged mice. They uncover benefits to metabolic health and certain indicators of aging and a sexually dimorphic effect on the heart.

Chung-Yang Yeh
Lucas C. S. Chini
Dudley W. Lamming
Research27 Nov 2024
Nature Aging

Volume: 4, P: 1760-1771
Protein restriction slows the development and progression of pathology in a mouse model of Alzheimer’s disease

There is growing need for ways to slow or prevent Alzheimer’s disease (AD). Here, the authors demonstrate that a low protein diet can protect against metabolic dysfunction, slow AD progression, and preserve cognitive function in a mouse model of AD.

Reji Babygirija
Michelle M. Sonsalla
Dudley W. Lamming
ResearchOpen Access18 Jun 2024
Nature Communications

Volume: 15, P: 1-20
Risk of major adverse cardiovascular events and all-cause mortality in type 2 diabetic patients receiving insulin versus non-insulin treatment intensification

Yu-Jie Lin
Peter Pin-Sung Liu
Jih-I Yeh
ResearchOpen Access13 Aug 2025
Scientific Reports

Volume: 15, P: 1-10
Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer

The orphan nuclear receptor COUP-TFII is highly expressed in metastatic prostate cancers and its overexpression accelerates prostate tumour progression in mouse models. Here, the author show that that loss of miR-101 and miR-27a in prostate cancer cells can lead to COUP-TFII expression which in turn directly regulates FOXM1 and CENPFfavouring prostate cancer metastasis.

Shih-Chieh Lin
Chung-Yang Kao
Ming-Jer Tsai
ResearchOpen Access25 Apr 2016
Nature Communications

Volume: 7, P: 1-14
Weekly gemcitabine plus 24-h infusion of high-dose 5-fluorouracil/leucovorin for locally advanced or metastatic carcinoma of the biliary tract

C Hsu
Y-C Shen
A-L Cheng
ResearchOpen Access13 Apr 2004
British Journal of Cancer

Volume: 90, P: 1715-1719
Association between holiday and weekend admissions and mortality outcomes among patients with acute myocardial infarction receiving percutaneous coronary intervention in Taiwan

Peter Pin-Sung Liu
Huai-Ren Chang
Jih-I Yeh
ResearchOpen Access17 Apr 2024
Scientific Reports

Volume: 14, P: 1-9
Global tilt angle in spinal alignment of asymptomatic older women with low bone mass

Ping-Chiao Tsai
Ssu-Hsien Lee
Kuang-Ting Yeh
ResearchOpen Access22 Oct 2024
Scientific Reports

Volume: 14, P: 1-9

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