While the conserved translin–TRAX complex (also known as C3PO) functions as an endoribonuclease that promotes RNA interference (RNAi) in animal cells, new research shows that C3PO is not involved in RNAi in Neurospora crassa but instead functions as a ribonuclease that removes the 5′ pre-tRNA fragments after processing of pre-tRNAs by RNase P. This function may be conserved in mammals.
- Liande Li
- Weifeng Gu
- Yi Liu