Marcelo D. T. Torres et al. turn toxic wasp-derived antimicrobial peptide polybia-CP into a viable antimicrobial with therapeutic activity in a mouse model. This study demonstrates that a physicochemical property-guided rational design strategy can be used to generate peptide antibiotics.
- Marcelo D. T. Torres
- Cibele N. Pedron
- Cesar de la Fuente-Nunez