During long-term culture, human embryonic stem (hES) cells may acquire chromosomal abnormalities that compromise their potential clinical utility. A study of 17 hES cell lines reveals various genomic changes, including trisomies and monosomies, an amplification at 20q11.21 and a derivative chromosome 18.
- Claudia Spits
- Ileana Mateizel
- Karen Sermon
