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Showing 1–7 of 7 results

Advanced filters: Author: Clemens Grimm Clear advanced filters

tRNA as an assembly chaperone for a macromolecular transcription-processing complex

Here, the authors solve a series of cryo-electron microscopy structures that show how transfer RNAs (tRNAs) can guide the assembly of the multisubunit poxvirus RNA polymerase, uncovering a role of tRNA as an assembly chaperone.

Julia Bartuli
Stefan Jungwirth
Utz Fischer
ResearchOpen Access04 Sept 2025
Nature Structural & Molecular Biology

P: 1-10
Structural basis of the complete poxvirus transcription initiation process

A series of cryo-EM structures examining transcription initiation by vaccinia poxvirus RNA polymerase reveal how viral transcription factors identify and melt a promoter and how a polymerase-associated helicase mediates promoter escape.

Clemens Grimm
Julia Bartuli
Utz Fischer
Research23 Sept 2021
Nature Structural & Molecular Biology

Volume: 28, P: 779-788
ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space

ProteoPlex optimizes buffer conditions for the isolation and purification of macromolecular complexes. The concurrent complex stabilization is beneficial for structure determination using X-ray crystallography or cryo-electron microscopy.

Ashwin Chari
David Haselbach
Holger Stark
Research03 Aug 2015
Nature Methods

Volume: 12, P: 859-865
Reversibility of a Point Mutation Induced Domain Shift: Expanding the Conformational Space of a Sucrose Phosphorylase

Michael Kraus
Clemens Grimm
Jürgen Seibel
ResearchOpen Access11 Jul 2018
Scientific Reports

Volume: 8, P: 1-6
Prognosis and quality of life in patients with locally advanced rectal cancer after abdominoperineal resection in the CAO/ARO/AIO-04 randomized phase 3 trial

Jochen Gaedcke
Malte Sahrhage
H. Leber
ResearchOpen Access13 Feb 2025
Scientific Reports

Volume: 15, P: 1-12
Correlation between structural heart disease and cardiac SARS-CoV-2 manifestations

Nägele, Graber et al. evaluate cardiac manifestations of SARS-CoV-2 in patients with structural heart disease. The authors find that detection of SARS-CoV-2 in heart tissue is associated with poorer survival.

Felix Nägele
Michael Graber
Can Gollmann-Tepeköylü
ResearchOpen Access11 Nov 2022
Communications Medicine

Volume: 2, P: 1-8
Novel form of X-linked nonsyndromic hearing loss with cochlear malformation caused by a mutation in the type IV collagen gene COL4A6

Simone Rost
Elisa Bach
Erdmute Kunstmann
Research29 May 2013
European Journal of Human Genetics

Volume: 22, P: 208-215