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Showing 1–12 of 12 results
Advanced filters: Author: Cornelis A. M. de Haan Clear advanced filters

  • Inbreeding depression has been observed in many different species, but in humans a systematic analysis has been difficult so far. Here, analysing more than 1.3 million individuals, the authors show that a genomic inbreeding coefficient (FROH) is associated with disadvantageous outcomes in 32 out of 100 traits tested.

    • David W Clark
    • Yukinori Okada
    • James F Wilson
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • Response to drug therapy in colorectal cancer (CRC) patients has been associated with tumour heterogeneity. Here the authors analyse DNA copy number aberrations in primary tumours from CRC patients and identify genetic variants that influence drug response.

    • Josien C. Haan
    • Mariette Labots
    • Gerrit A. Meijer
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-12

  • Mucins play critical roles in maintaining the human microbiome, with their O-glycosylated tandem repeats (TRs) providing important cues for microbiota. Here, the authors develop a cellular platform for producing TRs with defined O-glycan structures to dissect the functions of TR O-glycosylation.

    • Rebecca Nason
    • Christian Büll
    • Yoshiki Narimatsu
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • It is believed that human Influenza HA glycoprotein attaches to alpha2-6 linked sialic acids (SA) on cells, while avian viruses bind to alpha2-3 linked sialic acids, therewith contributing to host tropism. Here, Liu et al. show that mixing low-affinity alpha2-3 SA with low amounts of high-affinity alpha2-6 SA increases binding and entry of human viruses and the converse for avian virus. This shows that receptor recognition is not as strict as currently assumed and provides evidence that heteromultivalent interactions between human/avian HA and SA contributes to host adaptation.

    • Mengying Liu
    • Liane Z. X. Huang
    • Erik de Vries
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • The application of network science to several common neurological disorders challenges the idea that these disorders are either 'local' or 'global'. In this Review, Kees Stam proposes a model of hub overload and failure as a possible final common pathway in diverse neurological disorders.

    • Cornelis J. Stam
    Reviews
    Nature Reviews Neuroscience
    Volume: 15, P: 683-695

  • An analysis of 16 health-related quantitative traits in approximately 350,000 individuals reveals statistically significant associations between genome-wide homozygosity and four complex traits (height, lung function, cognitive ability and educational attainment); in each case increased homozygosity associates with a decreased trait value, but no evidence was seen of an influence on blood pressure, cholesterol, or ten other cardio-metabolic traits.

    • Peter K. Joshi
    • Tonu Esko
    • James F. Wilson
    Research
    Nature
    Volume: 523, P: 459-462

  • Tobias Ackermann et al. show that the C/EBPβ Liver-enriched inhibitory protein (LIP) induces aerobic glycolysis and mitochondrial respiration by suppressing the let-7 microRNA family that targets the Lin28b-mRNA. This study identifies LIP as a regulator of metabolic reprogramming that is reminiscent of cancer metabolism.

    • Tobias Ackermann
    • Götz Hartleben
    • Cornelis F. Calkhoven
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-15

  • ten Klooster et al. use ileum-derived organoids and report that bacterial and viral stimuli can drive IL22 production by T cells via distinct signaling pathways, and that IL22 can stimulate expression of anti-microbial and antiviral factors. This study sheds light on how enterocytes, fibroblasts and myeloid cells work synergistically to induce IL22 response against both bacteria and viruses.

    • Jean Paul ten Klooster
    • Marianne Bol-Schoenmakers
    • Raymond Pieters
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-13