This Review summarizes data on mouse strains with mutations that affect growth hormone (GH) and insulin-like growth factor 1 (IGF-1) action and their effects on lifespan. The outcome of corresponding or similar mutations in humans is described, as well as the potential mechanisms underlying increased longevity and the therapeutic benefits versus risks of medical disruption of the GH/IGF-1 axis in humans.
- Riia K. Junnila
- Edward O. List
- John J. Kopchick