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Showing 151–200 of 467 results

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Seismic events miss important kinematically governed grain scale mechanisms during shear failure of porous rock

Sound and Vision: In-situ synchrotron x-ray imaging with simultaneous acoustic monitoring captures grain scale damage mechanisms and unlocks the relationship between seismic and aseismic processes during catastrophic failure of porous rock.

Alexis Cartwright-Taylor
Maria-Daphne Mangriotis
Oxana V. Magdysyuk
ResearchOpen Access18 Oct 2022
Nature Communications

Volume: 13, P: 1-14
Enhancer selection dictates gene expression responses in remote organs during tissue regeneration

Sun et al. report that a steroid-responsive enhancer is preferentially required for expression and function of cebpd in remote tissues during heart regeneration.

Fei Sun
Jianhong Ou
Kenneth D. Poss
Research05 May 2022
Nature Cell Biology

Volume: 24, P: 685-696
Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease

Integration of GWAS and single-cell transcriptomic data from the entire nervous system systematically identifies cell types underlying brain complex traits and provides insights into the etiology of Parkinson’s disease.

Julien Bryois
Nathan G. Skene
Patrick F. Sullivan
Research27 Apr 2020
Nature Genetics

Volume: 52, P: 482-493
A phase I trial of docetaxel and 5-day continuous infusion of 5-fluorouracil in patients with advanced or recurrent breast cancer

M Ando
T Watanabe
T Taguchi
Research01 Jun 1998
British Journal of Cancer

Volume: 77, P: 1937-1943
Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington’s disease

Zinc finger protein transcription factors are developed for the selective silencing of the mutant huntingtin gene in human neurons in vitro and multiple animal models of Huntington’s disease in vivo while preserving expression of the wild-type allele.

Bryan Zeitler
Steven Froelich
H Steve Zhang
Research01 Jul 2019
Nature Medicine

Volume: 25, P: 1131-1142
Author Correction: A molecular atlas of cell types and zonation in the brain vasculature

Michael Vanlandewijck
Liqun He
Christer Betsholtz
Amendments and Corrections20 Jun 2018
Nature

Volume: 560, P: E3
RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock

Histamine causes vascular leakage by a direct and yet mechanistically poorly defined effect on endothelium. Here, the authors show that histamine elicits endothelial RhoA/Rock signaling and that inhibition of this pathway preserves the vascular barrier, thereby identifying novel pharmacological targets for histamine-mediated diseases.

Constantinos M. Mikelis
May Simaan
J. Silvio Gutkind
Research10 Apr 2015
Nature Communications

Volume: 6, P: 1-11
Direct measurement of the upper critical field in cuprate superconductors

The point at which a magnetic field kills superconductivity in the cuprates has been difficult to measure. Grissonnanche et al. use thermal conductivity measurements to reliably determine this field and find that it drops suddenly below some critical doping, suggesting the onset of a new competing phase.

G. Grissonnanche
O. Cyr-Choinière
Louis Taillefer
ResearchOpen Access12 Feb 2014
Nature Communications

Volume: 5, P: 1-8
Proximity-induced superconductivity in (Bi_1−xSb_x)₂Te₃ topological-insulator nanowires

Topological insulator nanowires are interesting because, in the presence of superconductivity, they may host elusive Majorana fermions. Here, superconductivity in (Bi_1−xSb_x)₂Te₃ topological-insulator nanowires is realized by using palladium diffusion, providing a tunable platform for Majorana zero modes.

Mengmeng Bai
Xian-Kui Wei
Yoichi Ando
ResearchOpen Access12 Apr 2022
Communications Materials

Volume: 3, P: 1-7
Membrane perturbation by lipidated Atg8 underlies autophagosome biogenesis

Lipidated Atg8 affects membrane morphology via two aromatic membrane-facing residues that are important for autophagy in budding yeast and mammalian cells.

Tatsuro Maruyama
Jahangir Md. Alam
Nobuo N. Noda
Research08 Jul 2021
Nature Structural & Molecular Biology

Volume: 28, P: 583-593
Trichostatin A induces apoptosis in lung cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway

Hak-Ryu Kim
Eun-Jung Kim
Raekil Park
ResearchOpen Access01 Dec 2006
Experimental & Molecular Medicine

Volume: 38, P: 616-624
Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models

Inclusions containing TDP43 are linked to pathologies in several neurodegenerative diseases such as ALS and FTD. Pathogenic TDP43 mutations are now found to shorten the protein's half-life in individual neurons. Stimulating autophagy with inhibitors improves TDP43 clearance and localization.

Sami J Barmada
Andrea Serio
Steven Finkbeiner
Research29 Jun 2014
Nature Chemical Biology

Volume: 10, P: 677-685
Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue

The soluble bioactive form of the transmembrane protein fibronectin type III domain containing 4 (sFNDC4) has anti-inflammatory effects and improves insulin sensitivity. Here the authors show that liver derived sFNDC4 signals through adipose tissue GPCR GPR116 to promote insulin-mediated glucose uptake.

Anastasia Georgiadi
Valeria Lopez-Salazar
Stephan Herzig
ResearchOpen Access20 May 2021
Nature Communications

Volume: 12, P: 1-21
Rad50 zinc hook functions as a constitutive dimerization module interchangeable with SMC hinge

The Mre11/Rad50 complex, which functions in genome surveillance, possesses antiparallel coiled-coil arms forming a ring-like structure similar to that of the SMC family proteins. Here the authors find that the Rad50 zinc hook functions similarly to the hinge of the SMC protein, and that the ring structure of the Mre11/Rad50 dimer also opens by disconnecting its globular head domains.

Hisashi Tatebe
Chew Theng Lim
Asako Furukohri
ResearchOpen Access17 Jan 2020
Nature Communications

Volume: 11, P: 1-11
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration

Monitoring the half-life of mutant huntingtin protein reveals how specific neurons are more susceptible to its toxic effects and to Huntington's disease.

Andrey S Tsvetkov
Montserrat Arrasate
Steven Finkbeiner
Research21 Jul 2013
Nature Chemical Biology

Volume: 9, P: 586-592
Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer

Hiromi Sakamoto
Kimio Yoshimura
Setsuo Hirohashi
Research18 May 2008
Nature Genetics

Volume: 40, P: 730-740
Molecular alterations in a patient with Turcot's syndrome

CF Rochlitz
I Heide
R Herrmann
Research01 Sept 1993
British Journal of Cancer

Volume: 68, P: 519-523
Quantum Hall effect of Weyl fermions in n-type semiconducting tellurene

The accidental band-crossing origin of Weyl nodes paired with the absence of sizeable band gaps hampers the exploitation of low-energy relativistic quasiparticles in Weyl semimetals. In a gate-tunable high-quality tellurene film, quantum Hall measurements unveil a topologically non-trivial π Berry phase caused by unconventional Weyl nodes in these tellurium two-dimensional sheets.

Gang Qiu
Chang Niu
Peide D. Ye
Research29 Jun 2020
Nature Nanotechnology

Volume: 15, P: 585-591
H3K27me3 demethylases alter HSP22 and HSP17.6C expression in response to recurring heat in Arabidopsis

Acclimation to high temperature increases tolerance of heat shock in plants. Here the authors show that JUMONJI H3K27me3 demethylases are needed for heat acclimation in Arabidopsis and act at loci encoding HEAT SHOCK PROTEINS to facilitate induction upon heat stress.

Nobutoshi Yamaguchi
Satoshi Matsubara
Toshiro Ito
ResearchOpen Access09 Jun 2021
Nature Communications

Volume: 12, P: 1-16
Nanoscale compositional mapping with gentle forces

Ricardo García
Robert Magerle
Ruben Perez
Reviews01 Jun 2007
Nature Materials

Volume: 6, P: 405-411
New dihydronaphthothiophene derivatives by the biological transformation of seriniquinone using marine-derived actinomycete Streptomyces albogriseolus OM27-12

Kohei Ishida
Teruki Tanaka
Takashi Fukuda
Research29 Nov 2021
The Journal of Antibiotics

Volume: 75, P: 9-15
Nutrients exported from upland stream water enlarge perennial biomass crops

Masaaki Chiwa
Yasuhiro Utsumi
Hiroshi Sawamura
ResearchOpen Access25 Jan 2021
Scientific Reports

Volume: 11, P: 1-8
HDL particles incorporate into lipid bilayers – a combined AFM and single molecule fluorescence microscopy study

Birgit Plochberger
Clemens Röhrl
Gerhard J. Schütz
ResearchOpen Access21 Nov 2017
Scientific Reports

Volume: 7, P: 1-10
Magnetic origami creates high performance micro devices

Despite the potential of self-assembly strategies for fabricating 3D micro-electronic devices, technological limitations prohibit widespread industrial adoption. Here, the authors report the magnetic field-assisted Origami-based assembly of high-performance devices with high yield.

Felix Gabler
Dmitriy D. Karnaushenko
Oliver G. Schmidt
ResearchOpen Access08 Jul 2019
Nature Communications

Volume: 10, P: 1-10
Arthropod phylogeny based on eight molecular loci and morphology

Gonzalo Giribet
Gregory D. Edgecombe
Ward C. Wheeler
Research13 Sept 2001
Nature

Volume: 413, P: 157-161
Secretory Type II Phospholipase A₂ (PLA2G2A) expression status in colorectal carcinoma derived cell lines and in normal colonic mucosa

Christian Praml
Lukas C Amler
Manfred Schwab
Research14 Oct 1998
Oncogene

Volume: 17, P: 2009-2012
Generation of Fusarium oxysporum-suppressive soil with non-soil carriers using a multiple-parallel-mineralization technique

Jamjan Meeboon
Akinori Ando
Makoto Shinohara
ResearchOpen Access13 May 2022
Scientific Reports

Volume: 12, P: 1-7
11-GHz waveguide Nd:YAG laser CW mode-locked with single-layer graphene

Andrey G. Okhrimchuk
Petr A. Obraztsov
ResearchOpen Access08 Jun 2015
Scientific Reports

Volume: 5, P: 1-7
Clinical and mutational spectrum of Japanese patients with recessive variants in SH3TC2

Jun-Hui Yuan
Akihiro Hashiguchi
Hiroshi Takashima
Research10 Jan 2018
Journal of Human Genetics

Volume: 63, P: 281-287
Report of the Working Group for Dietary Salt Reduction of the Japanese Society of Hypertension: (1) Rationale for Salt Restriction and Salt-Restriction Target Level for the Management of Hypertension

Yuhei Kawano
Katsuyuki Ando
Hirotsugu Ueshima
Reviews01 Oct 2007
Hypertension Research

Volume: 30, P: 879-886
Photoactivatable fluorescent proteins

Konstantin A. Lukyanov
Dmitry M. Chudakov
Vladislav V. Verkhusha
Reviews15 Sept 2005
Nature Reviews Molecular Cell Biology

Volume: 6, P: 885-890
Tropical Soils and their Origins

J. D'HOORE
Books & Arts14 May 1955
Nature

Volume: 175, P: 827-828
Ameloblastin induces tumor suppressive phenotype and enhances chemosensitivity to doxorubicin via Src-Stat3 inactivation in osteosarcoma

Toshinori Ando
Yasusei Kudo
Takashi Takata
ResearchOpen Access05 Jan 2017
Scientific Reports

Volume: 7, P: 1-11
Usefulness of circulating tumor DNA by targeting human papilloma virus-derived sequences as a biomarker in p16-positive oropharyngeal cancer

Ken Akashi
Toshihiko Sakai
Tatsuya Yamasoba
ResearchOpen Access12 Jan 2022
Scientific Reports

Volume: 12, P: 1-7
Wetting Induced Oxidation of Pt-based Nano Catalysts Revealed by In Situ High Energy Resolution X-ray Absorption Spectroscopy

Yi-Tao Cui
Yoshihisa Harada
Masaharu Oshima
ResearchOpen Access03 May 2017
Scientific Reports

Volume: 7, P: 1-8
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line

The FANTOM4 study identified transcriptional start sites active during proliferation arrest and differentiation of the human monocytic cell line THP-1. Systematic knockdown of 52 transcription factors provide support for their model in which a complex transcriptional network regulates the differentiation process.

Harukazu Suzuki
Alistair R R Forrest
Yoshihide Hayashizaki
Research19 Apr 2009
Nature Genetics

Volume: 41, P: 553-562
Long-read sequencing identifies GGC repeat expansions in NOTCH2NLC associated with neuronal intranuclear inclusion disease

Long-read sequencing identifies a GGC repeat expansion in NOTCH2NLC that is associated with neuronal intranuclear inclusion disease, a progressive neurodegenerative disorder. The expansion results in abnormal anti-sense transcripts that could contribute to disease pathogenesis.

Jun Sone
Satomi Mitsuhashi
Gen Sobue
Research22 Jul 2019
Nature Genetics

Volume: 51, P: 1215-1221
Comparative transcriptomics reveal developmental turning points during embryogenesis of a hemimetabolous insect, the damselfly Ischnura elegans

Sabrina Simon
Sven Sagasser
Rob DeSalle
ResearchOpen Access19 Oct 2017
Scientific Reports

Volume: 7, P: 1-14
Dynamics of chemical processes in polar solvents

Peter J. Rossky
John D. Simon
Reviews28 Jul 1994
Nature

Volume: 370, P: 263-269
Left atrial reverse remodeling improves risk stratification in patients with heart failure with recovered ejection fraction

Masayuki Shiba
Takao Kato
Takeshi Kimura
ResearchOpen Access16 Mar 2022
Scientific Reports

Volume: 12, P: 1-9
Behavioral Effects of Central Administration of The Novel CRF Antagonist Astressin in Rats

Mariarosa G Spina
Ana M Basso
GF Koob
Research01 Mar 2000
Neuropsychopharmacology

Volume: 22, P: 230-239
Quantitative multidimensional phenotypes improve genetic analysis of laterality traits

Judith Schmitz
Mo Zheng
Silvia Paracchini
ResearchOpen Access19 Feb 2022
Translational Psychiatry

Volume: 12, P: 1-8
Magnetic flux tubes on the Sun

H. C. Spruit
B. Roberts
Reviews04 Aug 1983
Nature

Volume: 304, P: 401-406
T_H1 and T_H2 cells: a historical perspective

Foo Y. Liew
Reviews01 Jan 2002
Nature Reviews Immunology

Volume: 2, P: 55-60
An NEFH founder mutation causes broad phenotypic spectrum in multiple Japanese families

Masahiro Ando
Yujiro Higuchi
Hiroshi Takashima
Research28 Jan 2022
Journal of Human Genetics

Volume: 67, P: 399-403
A retrospective analysis of the relationship between anti-cyclic citrullinated peptide antibody and the effectiveness of abatacept in rheumatoid arthritis patients

Daihei Kida
Nobunori Takahashi
Toshihisa Kojima
ResearchOpen Access12 Nov 2020
Scientific Reports

Volume: 10, P: 1-9
Effect of misonidazole pretreatment on nitrogen mustard-induced DNA cross-linking in mouse tissues in vivo

D Murray
R E Meyn
Research01 Dec 1984
British Journal of Cancer

Volume: 50, P: 801-808
Greater cerebellar gray matter volume in car drivers: an exploratory voxel-based morphometry study

Hiroyuki Sakai
Takafumi Ando
Yuji Uchiyama
ResearchOpen Access18 Apr 2017
Scientific Reports

Volume: 7, P: 1-7
Excitons in nanoscale systems

Gregory D. Scholes
Garry Rumbles
Reviews01 Sept 2006
Nature Materials

Volume: 5, P: 683-696

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