The next challenge in rheumatoid arthritis (RA) therapy is the maintenance of disease remission with a minimal-treatment regimen. In this Review the authors propose that this goal could be achieved by restoring a state of immune tolerance and discuss antigen-independent and antigen-specific approaches for the induction of tolerance in the treatment of RA.
- Salvatore Albani
- Eva C. Koffeman
- Berent Prakken
