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Aging is a risk factor for Parkinson’s disease; however, how DNA damage accumulation, a hallmark of aging, contributes to its pathophysiology remains incompletely understood. Here, the authors identify a blood-based DNA damage signature that is associated with disease progression in patients with Parkinson’s disease.

Despite being a virulence factor, candidalysin toxin is essential for Candida albicans to penetrate the oral epithelium to establish and maintain non-infectious colonization

An NNMT inhibitor reduces tumour burden and metastasis in multiple mouse cancer models and restores immune checkpoint blockade efficacy by decreasing cancer-associated-fibroblast-mediated recruitment of myeloid-derived suppressor cells and reinvigorating CD8⁺ T cell activation.

This study shows that structural complexity of cortical and subcortical areas, measured from standard anatomical MRI, can predict Parkinson’s patient response to deep brain stimulation using advanced hypergraph modeling techniques.

Assessments of future virtual water trading are still lacking. Here the authors estimated the global virtual water trade throughout the century and found that virtual green water exports and virtual blue water exports at least triple to more than 3200 bcm and 170 bcm, respectively, by the end of the century.

A tree-like arrangement of dichroic mirrors and multiple cameras coupled with an iterative spectral unmixing algorithm enables multispectral imaging of live cells in up to eight spectral channels with diffraction-limited spatial resolution and temporal resolution of 0.3 s for imaging a full cell volume.

The impact of humans on megafaunal extinction is Australia is unclear. Here, the authors show burn patterns on eggshells of the extinct megafaunal bird, Genyornis newtoni, created by humans across Australia, suggesting that human predation contributed to the extinction of this bird around 47 thousand years ago.

Cell-traversal protein for ookinetes and sporozoites (CelTOS) is a malaria vaccine candidate. Here, the authors characterize mouse monoclonal antibodies recognizing different CelTOS epitopes, and demonstrate protection from transgenic parasites containing P. falciparum or P. vivax as well as multistage activity.

Motion vision in many animals is split into pathways for bright (ON) and dark (OFF) edges, driven by luminance changes. Here the authors show how in Drosophila color selectively contributes to ON-motion, enhancing detection of saliently colored objects.

The tumor microenvironment influences the metabolic behavior of cancer cells. Here, using Dual Ribosome Profiling, the authors uncover a cancer-stromal cell interaction under glucose starvation that increases nutrient availability, in response to type I interferon. In addition, in vivo, immune checkpoint blockade triggers metabolic constraints in T cells, reducing their proliferation and cytotoxicity.

Synthesizing the cellular proteome is demanding and finely regulated. Here, the authors show that mTORC1 cooperates with tRNA wobble modification to promote ribosomal protein synthesis, thus supporting the high translational demands of cell growth.

Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) are powerful in vitro models. Here the authors report CONTRAX, an open-access, versatile, and streamlined pipeline for quantitative tracking of the contractile dynamics of single hiPSC-CMs over time at increased throughput.

This study, together with a companion manuscript, show that, in mice, weight loss as a result of GIP receptor antagonism requires, and potentiates, functional GLP-1 receptor signalling in the brain, explaining how both GIP receptor agonists and antagonists trigger weight loss through different mechanisms.

Serotonergic enterochromaffin cells of the intestine exhibit distinct sensory, secretory and physiological properties depending on their location within the complex crypt–villus architecture of the gut.

Single-cell transcriptomics enhanced our ability to profile heterogeneous cell populations. It is not known which statistical frameworks are performant to detect subpopulation-level responses. Here, the authors developed a simulation framework to evaluate various methods across a range of scenarios.

A Bayesian phylogeographic analysis of vocabulary from 306 Pama–Nyungan languages suggests that the language family rose to dominance across Australia in a process of rapid replacement following an origin in the Gulf Plains region during the mid-Holocene.

Riparian vegetation densities critically mediate the morphodynamics of meandering rivers: plants slow the rate at which channels move laterally and reinforce the key, first-order control that curvature exerts on meander planform evolution.

Some species of planktonic foraminifera - microscopic organisms that occur throughout the world’s oceans - are found in the chilly waters of both the Antarctic and Arctic. Given that the tropics lie between them, molecular evidence that there has been gene flow between these populations comes as a surprise.

The accretion disk from a star tidally disrupted by a supermassive black hole undergoes Lense–Thirring precession with strong, quasi-periodic X-ray flux and temperature modulations.

Analysis of the panchromatic transmission spectrum of the warm, low-density, Neptune-sized exoplanet WASP-107b from instruments aboard the HST and JWST suggests that tidal interaction with its host star led to changes in its atmospheric chemistry.

Evidence of a large temperature difference between dawn and dusk has been observed on the exoplanet WASP-107 b. This planet is so cool that it was not expected to exhibit this phenomenon, implying a need to further explore the exoplanet population.

Sequential neuronal activity patterns are tokens of neural computations. Here, the authors show that a brain region that is specialized in memory processing – the dentate gyrus – is critical for initiating and organizing sequences of neural activity.

Here, the authors investigate the proteome trajectory of human iPSCs differentiating into hepatic stellate cells (diHSCs) and identify RORA as a key transcription factor that governs metabolic reprogramming essential for diHSCs’ commitment, identity, and quiescent phenotype.

The range of timescales and luminosities measured from the nearby fast radio burst FRB 20200120E observationally connects these extreme extragalactic transients with studies of Galactic neutron stars.

The southwest corner of Western Australia has been subject to a serious drought in recent decades, whose ultimate cause remains unclear. A comparison of precipitation records in the area of drought and an ice core from East Antarctica reveal a significant inverse correlation between precipitation in the two locations, and suggest that the current drought may be highly unusual compared with the past 750 years of variability.

Constraining the timing of crustal processes and impact events remains challenging. Here, the authors show that atom probe tomography can produce highly accurate U-Pb isotopic age constraints in baddeleyite crystals, which is a common phase in terrestrial, Martian, Lunar and asteroidal materials.

The mechanisms controlling the formation of cellular adhesions are not fully understood. Here, the authors use single molecule tracking and super-resolution imaging to show that the actin cytoskeleton regulates integrin diffusion in the developing Drosophila embryo.

How interactions between binding partners form or break is hidden in the transition paths from the encounter to the formation of a stable complex. Here authors use single‐molecule spectroscopy to measure the transition path times for the association of two intrinsically disordered proteins that form a folded dimer upon binding and identify a metastable encounter complex.

Many models assume a universal carbon use efficiency across forest biomes, in contrast to assumptions of other process-based models. Here the authors analyse forest production efficiency across a wide range of climates to show a positive relationship with annual temperature and precipitation, indicating that ecosystem models are overestimating forest carbon losses under warming.

Analyses of in vivo models, cell lines and patient-derived samples show that apolipoprotein B mRNA-editing catalytic subunit 3B (APOBEC3B) not only restrains lung tumor initiation but also that its upregulation is associated with resistance to targeted therapies. This study highlights the complex and context-dependent role of APOBEC3B in lung cancer.