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How fast can animals run? Here, the authors show that maximum running speed is limited by different musculoskeletal constraints across animal size: kinetic energy capacity in small animals, and work capacity in large animals.

Vaziri et al. examined how humans detect changes in auditory pitch, revealing that listeners rely on correlations in sound intensity over frequency and time, processing that is reminiscent of visual motion detection.

A follow-up analysis of a clinical trial that evaluated anti-PD-1 therapy in patients with cancer who are living with HIV provides mechanistic insights into transcriptomic, cellular and cytokine changes related to immune checkpoint inhibitor treatment and identifies a signature associated with clinical response.

Storms cool the Southern Ocean surface in summer mainly by deepening the mixed layer, but increased air–sea turbulent fluxes reduce ocean heat loss and partly offset the cooling, according to glider observations, reanalyses and satellite data.

Despite the growing literature and widespread interest in transformational adaptation, its definition remains contested. The results of a global expert survey reveal broad agreement on 13 key elements that should be included in defining transformational adaptation.

Freshwater ecosystems and biodiversity are declining quickly. By integrating global environmental, socioeconomic, and biological data, this study identifies the key conditions associated with imperilment of freshwater fishes.

The cytoplasm can be partitioned into distinct compartments by microtubule structures, which can be stabilized by distinct mechanisms in different species.

Battery electrode binders are hard to image but strongly affect battery performance. Here, authors use silver and bromine staining to reveal common cellulose- and rubber-based binders in graphite and Si negative electrodes and identify processing that reduces electrode resistance.

Greenwald, Nederlof and colleagues developed a computational pipeline analyzing multiplex imaging data and established spatial patterns within breast cancer microenvironment that are predictive of immune checkpoint blockade response across treatment time course.

A modular, point-of-care device combining hemispheric plasmonic nanoarrays and automated microfluidics enables nucleic acid amplification and metabolic cell viability assay for rapid bacterial identification and antibiotic susceptibility testing.

Non-equilibrium two-dimensional melting is less understood than its equilibrium counterpart. Now it is shown that topologically driven melting in a two-dimensional crystal of charged colloids is the same irrespective of the mechanisms that generate the defects

Boosting mitochondrial metabolism in neurons in central memory circuits by enhancing Ca²⁺ retention in the mitochondrial matrix is shown to improve long-term memory formation in flies and mice.

The meningeal compartment communicates with the brain to modulate homeostatic functions. Here, the authors demonstrate that natural killer (NK) cells and innate lymphoid cells (ILC) 1 shape synaptic neuronal transmission and affect mouse behavior.

Imaging highly exothermic reactions in high spatial and temporal resolution to understand their underlying reaction mechanisms is challenging. Here, the authors develop a high-speed microscopy/pyrometry imaging system to successfully observe reactive sintering in a nanothermite reaction in-operando.

A flexible, floating microelectrode array that has a reconfigurable spiral thread design can be used to create large-scale, long-term brain–computer interfaces in the primate brain.

Newly developed mouse models that enable cell-specific analyses of proteostasis dynamics across the lifespan of the mice reveal key aspects of neuronal proteostasis with ageing.

While excitonic semiconductors offer appealing optical properties, their application for competitive optoelectronic devices has remained limited. Here, the authors report the realization of broadband exciton-polariton photodiodes based on a layered excitonic semiconductor, WS₂, contacted by tin-doped indium oxide in an open optical cavity design, showing ~MHz bandwidth at room temperature.

This study applies machine learning to fMRI data to map developmental variations in functional connectivity, uncovering heterogeneity across individuals and cortical regions that predicts neurocognitive maturation in youth.

Division of embryonic cells with an incomplete contractile ring occurs by a ratchet mechanism with repeated cycles of cytoplasmic stiffening, which stabilizes the contractile actin band, and fluidization, which enables band ingression.

Using artificial neural networks applied to human data, Eckstein et al. show that good models of reinforcement learning require memory components that track representations of the past.

Projected impacts of climate change on malaria burden in Africa by 2050 highlight the urgent need for climate-resilient malaria control strategies and robust emergency response systems to safeguard progress towards malaria eradication.

Natural and sexual selection can be in opposition favouring different trait sizes, but disentangling these processes empirically is difficult. Here Okada et al. show that predation on males shifts the balance of selection in experimentally evolving beetle populations, disfavoring a sexually-selected male trait but increasing female fitness.

Inspired by thermal expansion and refractive index changes in the nanostructures of iridescent Morpho butterfly scales, scientists demonstrate upconverted mid-wave infrared detection with a temperature sensitivity of 18–62 mK and a heat-sink-free response speed of 35–40 Hz.

Comparative genomics and high-resolution mass spectrometry reveal the biosynthetic gene clusters, and vast chemical diversity of natural products that they encode, in Photorhabdus and Xenorhabdus, bacteria that interact with hosts as symbionts and entomopathogens.

Kozai, Fernandez-Martinez et al. use high-speed atomic force microscopy to study the permeability barrier of yeast nuclear pore complexes. They show that karyopherins remodel a central plug that shapes barrier dynamics and disorder within the pore.

How the translation speed of tropical cyclones has changed in recent decades and will change in the future has been the subject of debate. Model results show that on average, they have not slowed down in the past, but despite a slowing of tropical cyclones at higher latitudes, a poleward shift in their mean track location causes a general speed up under high greenhouse gas emissions.

Treatment-seeking for fever is widely used to estimate treatment of childhood infections, but cross-country comparisons are problematic. Here, the authors estimate the probability of seeking treatment for fever at public facilities across 29 countries by quantifying person-level latent variables.

Coherent control of plasmon wavepackets is essential for quantum information processing using flying electron qubits. Here, the authors demonstrate a method to isolate and select electron channels contributing to a plasmon using a cavity formed by local constrictions, enabling precise control of plasmon eigenstates.

Keshishian, Mischler et al. report that a recurrent automatic speech recognition system aligns closely with brain organization: model layers map to distinct cortical regions and naturally learn to encode a parallel progression from acoustic to phonetic, lexical and semantic content.

A lab-scale proof-of-principle demonstration of a quantum network comprising one server chip and 20 client photonic chips implementing twin-field quantum key distribution shows excellent scalability and reliability and yields a pathway towards future large-scale networks.

Oxytocin promotes social behaviors, but its cortical targets remain unclear. Here, authors show that oxytocin activates local interneurons in the rat prefrontal cortex, enhancing sociability through top-down control of the basolateral amygdala.

Neuromorphic computing processes data faster and with less energy than electronics. Here, authors demonstrate a reconfigurable photonic reservoir computer that performs multiple machine learning tasks in parallel at ultrafast rates while using extremely low energy per operation.

Cells struggle to migrate on soft substrates, which don’t provide enough traction. Here, the authors show that rapid, cyclic changes in substrate rigidity allow cells to overcome this limitation and move quickly.

The contribution of ether lipid species in cancer cell fate has not been fully understood yet. Here the authors show that malignant cancer cells employ ether lipids to modulate membrane biophysical properties, enhancing iron endocytosis and ferroptosis susceptibility.

Single-particle tracking experiments in intact cells reveal dynamic co- and post-translational interactions of the TRiC–PFD chaperonin complex with client proteins during in vivo protein folding.

This study reveals how controlling the contact angle enables clean, residue-free peeling of gallium-based liquid metals without chemical treatments, offering a simple method for precise and contamination-free patterning of liquid metal structures.

iGluSnFR4f and iGluSnFR4s are the latest generation of genetically encoded glutamate sensors. They are advantageous for detecting rapid dynamics and large population activity, respectively, as demonstrated in a variety of applications in the mouse brain.

Space missions imaging small asteroid moons revealed the variety in shapes. Here, the authors show that repeated low-speed collisions can explain the shape of Selam, which is the smaller component in Dinkinesh-Selam binary asteroid system.

Wei et al. perform spatial transcriptomic profiling on synovial tissue biopsy samples from individuals with recent-onset rheumatoid arthritis, finding TGFβ signaling and fibrogenic fibroblast activation drive a treatment-refractory tissue phenotype.

Magnetic heliknotons are hopfions embedded in helical spin backgrounds. Current-induced nucleation and Hall-effect-free motion of isolated magnetic heliknotons is demonstrated in the chiral magnet FeGe.

CRISPR-Cas12a diagnostics are limited by strict PAM requirements. Here, authors show that higher temperatures activate numerous noncanonical PAMs, enabling a versatile one-pot platform that improves sensitivity, specificity, and rapid on-site pathogen detection.

How the complex interplay between multiple nutrients within the microenvironment dictates potential sites of metastatic cancer growth is explored.

The International Brain Laboratory presents a brain-wide electrophysiological map obtained from pooling data from 12 laboratories that performed the same standardized perceptual decision-making task in mice.

Combining behavioral data, electrophysiology and modeling, the authors show that the human brain synchronizes visual signals by adjusting axonal conduction speed in the retina, revealing a previously unknown mechanism for precise perceptual timing.

MicroRNAs guide Argonaute proteins to repress gene expression. Here, the authors define the binding rules for five Drosophila miRNAs, showing a narrow preference for canonical seed sites and identifying non-canonical sites with comparable affinities.

The authors developed MOBILE, a compact photoacoustic imaging system for non-invasive hemodynamic monitoring in motion. It reveals how microcirculation adapt during exercise, offering a dynamic window into cardiovascular health.