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Showing 1–8 of 8 results
Advanced filters: Author: D Fussenegger Clear advanced filters

  • Synthetic mammalian cells engineered to synthesize a painkiller in response to volatile spearmint reduce chronic pain in mice and do not seem to elicit adverse effects.

    • Daniel D. Lewis
    • Cheemeng Tan
    News & Views
    Nature Biomedical Engineering
    Volume: 2, P: 58-59

  • Synthetic biological devices can be engineered to achieve high levels of precision and specificity, which makes them ideally suited for use in clinical settings. Devices are being developed to meet a range of biomedical needs, including specific cancer therapies and metabolic control.

    • Wilfried Weber
    • Martin Fussenegger
    Reviews
    Nature Reviews Genetics
    Volume: 13, P: 21-35

  • 'Omics' technologies are making it possible to simultaneously measure a substantial portion of the molecular components of a cell. This article describes the challenges that need to be confronted to develop and refine genome-scale reconstructions of signalling networks.

    • Daniel R. Hyduke
    • Bernhard Ø. Palsson
    Reviews
    Nature Reviews Genetics
    Volume: 11, P: 297-307

  • Engineering gene expression systems that can be programmed to respond to specific environmental conditions is challenging. Here, the authors develop a synthetic bow-tie circuit that is able to sense signals from microRNA molecules and affect a change in protein dynamics in mammalian cells.

    • Laura Prochazka
    • Bartolomeo Angelici
    • Yaakov Benenson
    Research
    Nature Communications
    Volume: 5, P: 1-12

  • Polymer hydrogel patches that are capable of supporting living cells and guiding light are used to perform in-vivo optical sensing and therapy in living mice. Tasks performed include toxicity testing and glucose regulation.

    • Myunghwan Choi
    • Jin Woo Choi
    • Seok Hyun Yun
    Research
    Nature Photonics
    Volume: 7, P: 987-994