Nature Search

Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer

Assessment of PD-1 and PD-L1 expression can be predictive of immunotherapy response in lung cancer. Here the authors assess the clinical toxicity, safety and quality of non-invasive imaging of PD-1 and PD-L1 expression in 13 patients with advanced lung cancer prior to treatment with immunotherapy and show it correlates with response.

A. N. Niemeijer
D. Leung
A. J. de Langen
ResearchOpen Access07 Nov 2018
Nature Communications

Volume: 9, P: 1-5
Perception of Emotionally Toned Words

D. E. BROADBENT
MARGARET GREGORY
Research05 Aug 1967
Nature

Volume: 215, P: 581-584
Spatial and temporal patterns of Krüppel gene expression in early Drosophila embryos

Douglas C. Knipple
Eveline Seifert
Herbert Jäckle
Research05 Sept 1985
Nature

Volume: 317, P: 40-44
Deficient Activity of Hepatic Pyruvate Dehydrogenase and Pyruvate Carboxylase in Reye's Syndrome

Brian H Robinson
D Grant Gall
Ernest Cutz
Research01 Apr 1977
Pediatric Research

Volume: 11, P: 279-281
Enzymatic Investigations of Partially Purified Hog Kallikrein

D. A. CHAMBERS
C. BOSSER
G. L. NARDI
Research30 Mar 1963
Nature

Volume: 197, P: 1300-1301
Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

The nuclear farnesoid X receptor (FXR) is activated by bile acids and influences energy metabolism. Here, the authors report a small molecule inhibitor of FXR, glycine-ß-muricholic acid, which inhibits FXR in the intestine and improves metabolic homeostasis by repressing intestinal ceramide synthesis.

Changtao Jiang
Cen Xie
Frank J. Gonzalez
ResearchOpen Access15 Dec 2015
Nature Communications

Volume: 6, P: 1-18
Alterations in brain cholecystokinin receptors after fasting

A. Saito
J. A. Williams
I. D. Goldfine
Research12 Feb 1981
Nature

Volume: 289, P: 599-600
Spectroscopic Investigation of Rubredoxin and Ferredoxin

N. M. ATHERTON
K. GARBETT
J. E. STANGROOM
Research01 Nov 1966
Nature

Volume: 212, P: 590-593
Characterizing the metabolic effects of the selective inhibition of gut microbial β-glucuronidases in mice

Marine P. M. Letertre
Aadra P. Bhatt
Jonathan R. Swann
ResearchOpen Access19 Oct 2022
Scientific Reports

Volume: 12, P: 1-11
Aggregation, Variance and the Mean

L. R. TAYLOR
Research04 Mar 1961
Nature

Volume: 189, P: 732-735
Preliminary Stratigraphical Studies of the East Rudolf Basin, Kenya

CARL F. VONDRA
GARY D. JOHNSON
A. K. BEHRENSMEYER
Research28 May 1971
Nature

Volume: 231, P: 245-248
Conservation of T-DNA in Plants Regenerated from Hairy Root Cultures

Chantal David
Mary-Dell Chilton
Jacques Tempé
Research01 Jan 1984
Bio/Technology

Volume: 2, P: 73-76
Agrobacterium expressing a type III secretion system delivers Pseudomonas effectors into plant cells to enhance transformation

Agrobacterium infection can cause defense responses in many plants, which leads to transformation recalcitrance. Here, the authors express type III secretion system in Agrobacterium to deliver effector proteins into plant cells to suppress host defense responses and thus enhance transformation in some plant species.

Vidhyavathi Raman
Clemencia M. Rojas
Kirankumar S. Mysore
ResearchOpen Access11 May 2022
Nature Communications

Volume: 13, P: 1-14
Clinical, Morphological, and Biochemical Alterations in Acute Intestinal Yersiniosis

E V O'loughlin
G Humphreys
D G Gall
Research01 Jul 1986
Pediatric Research

Volume: 20, P: 602-608
Sequence of a ribosomal RNA gene intron from Tetrahymena

Martha A. Wild
Reinhold Sommer
Research14 Feb 1980
Nature

Volume: 283, P: 693-694
Intervening sequences in ribosomal RNA genes and bobbed phenotype in Drosophila hydei

Gerald Franz
Werner Kunz
Research13 Aug 1981
Nature

Volume: 292, P: 638-640
Seamounts in the Gulf of Guinea

G. P. D. HALL
Research24 Dec 1966
Nature

Volume: 212, P: 1443-1444
Factors affecting Proteolytic Activity of Extracts from Normal and Tumour Tissues of Tobacco

C. GAINOR
F. D. CRISLEY
Research17 Mar 1962
Nature

Volume: 193, P: 1076-1077
Toxic Hazard from formulating the Insecticide Dimethoate in Methyl ‘Cellosolve’

JOHN E. CASIDA
D. M. SANDERSON
Research11 Feb 1961
Nature

Volume: 189, P: 507-508
Foundress numbers and the timing of selective events during interactions between figs and fig wasps

Bao-Fa Sun
Rui-Wu Wang
ResearchOpen Access04 Mar 2019
Scientific Reports

Volume: 9, P: 1-8
Structure of the Nuclear Pore in Higher Plants

K. ROBERTS
D. H. NORTHCOTE
Research24 Oct 1970
Nature

Volume: 228, P: 385-386
Genome-wide protein–DNA binding dynamics suggest a molecular clutch for transcription factor function

Competition ChIP with a sequence-specific S. cerevisiae transcription factor, Rap1, reveals that long Rap1 residence is coupled to transcriptional activation, whereas fast binding turnover is linked to low transcriptional output, suggesting that DNA-binding events that appear identical by conventional ChIP may have different underlying modes of interaction, leading to opposing functional outcomes.

Colin R. Lickwar
Florian Mueller
Jason D. Lieb
Research11 Apr 2012
Nature

Volume: 484, P: 251-255
Hook Whistler—a New Equatorial Whistler observed by Injun 3

D. A. GURNETT
S. D. SHAWHAN
G. W. PFEIFFER
Research24 Dec 1966
Nature

Volume: 212, P: 1442-1443
Maternal bile acid transporter deficiency promotes neonatal demise

The mechanisms underlying perinatal mortality due to intrahepatic cholestasis of pregnancy are not fully understood. Here, the authors show that absence of the nuclear receptor and bile acid regulator Nrli2 and the biliary transporter Abcb11 strongly reduces maternal serum bile acid levels, improving neonatal survival.

Yuanyuan Zhang
Fei Li
John D. Schuetz
ResearchOpen Access29 Sept 2015
Nature Communications

Volume: 6, P: 1-10
Inhibition of myogenesis in a rat myoblast line by 5-bromodeoxyuridine

JACKILYNN ROGERS
STEPHEN K. C. NG
B. D. SANWAL
Research31 Jul 1975
Nature

Volume: 256, P: 438-440
Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine

Yoshiya Kawaguchi and colleagues show that a Sox9-positive progenitor pool located in the epithelia of the biliary and pancreatic ducts of adult mice serves as a continuous source of intestinal cells, hepatocytes and pancreatic acinar cells, identifying a shared pathway underlying the cellular renewal of these adult endodermal organs.

Kenichiro Furuyama
Yoshiya Kawaguchi
Shinji Uemoto
Research28 Nov 2010
Nature Genetics

Volume: 43, P: 34-41
Microbial Production of Carbon Monoxide from Flavonoids

D. W. S. WESTLAKE
J. M. ROXBURGH
G. TALBOT
Research11 Feb 1961
Nature

Volume: 189, P: 510-511
Use of Electron Autoradiography for investigating Viral Infection in Tissue Culture

V. M. ZHDANOV
G. A. KLISENKO
Y. M. ZHANTIEVA
Research06 Jun 1964
Nature

Volume: 202, P: 1028-1029
Gene transfer to plants by diverse species of bacteria

Wim Broothaerts
Heidi J. Mitchell
Richard A. Jefferson
Research10 Feb 2005
Nature

Volume: 433, P: 629-633
The GenomeAsia 100K Project enables genetic discoveries across Asia

Using whole-genome sequencing data from 1,739 individuals, the GenomeAsia 100K Project catalogues genetic variation, population structure and disease associations to facilitate genetic studies in Asian populations and increase representation in genetics studies worldwide.

Jeffrey D. Wall
Eric W. Stawiski
Andrew S. Peterson
ResearchOpen Access04 Dec 2019
Nature

Volume: 576, P: 106-111
Oscillatory stimuli differentiate adapting circuit topologies

Negative feedback and incoherent feed-forward loops are the only circuit motifs that can adapt in response to stimuli. Rahi et al. describe signatures that allow discriminating between these two motifs and demonstrate the approach in yeast cell cycle timing and C. elegans olfaction.

Sahand Jamal Rahi
Johannes Larsch
Frederick R Cross
Research28 Aug 2017
Nature Methods

Volume: 14, P: 1010-1016
Calcium Exchange Diffusion in a Porous Phospholipid Ion-exchange Membrane

D. VAN BREEMEN
C. VAN BREEMEN
Research30 Aug 1969
Nature

Volume: 223, P: 898-900
A position effect in the control of transcription at yeast mating type loci

Kim A. Nasmyth
Kelly Tatchell
Michael Smith
Research22 Jan 1981
Nature

Volume: 289, P: 244-250
Non-electrolyte Probes of Membrane Structure in ADH-treated Toad Urinary Bladder

RICHARD J. PIETRAS
ERNEST M. WRIGHT
Research25 Jan 1974
Nature

Volume: 247, P: 222-224
Rhythmic gene expression in pituitary depends on heterologous sensitization by the neurohormone melatonin

Charlotte von Gall
Martine L. Garabette
Jörg H. Stehle
Research11 Feb 2002
Nature Neuroscience

Volume: 5, P: 234-238
The Effect of Protein-Calorie Malnutrition on the Developing Liver

Karen Opleta
J Decker Butzner
D Grant Gall
Research01 May 1988
Pediatric Research

Volume: 23, P: 505-508
Comparing Resistances of Four-Terminal Resistors

D. C. GALL
Research09 Dec 1939
Nature

Volume: 144, P: 982
Rfx6 directs islet formation and insulin production in mice and humans

Pancreatic β-cells release insulin, which controls energy homeostasis in vertebrates, and its lack causes diabetes mellitus. The transcription factor neurogenin 3 (Neurog3) initiates differentiation of β-cells and other islet cell types from pancreatic endoderm; here, the transcription factor Rfx6 is shown to direct islet cell differentiation downstream of Neurog3 in mice and humans. This may be useful in efforts to generate β-cells for patients with diabetes.

Stuart B. Smith
Hui-Qi Qu
Michael S. German
Research11 Feb 2010
Nature

Volume: 463, P: 775-780
Isolation of chromosome 21–specific yeast artificial chromosomes from a total human genome library

I.M. Chumakov
I. Le Gall
D. Cohen
Research01 Jun 1992
Nature Genetics

Volume: 1, P: 222-225
Ribosomal DNA Connectives between Human Acrocentric Chromosomes

A. S. HENDERSON
D. WARBURTON
K. C. ATWOOD
Research14 Sept 1973
Nature

Volume: 245, P: 95-97
Similar Polymorphisms in an Insect and a Land Snail

D. F. OWEN
Research13 Apr 1963
Nature

Volume: 198, P: 201-203
Targeting bile-acid signalling for metabolic diseases

The recent awareness that bile acids act as complex metabolic integrators and signalling factors has led to the recognition of bile-acid signalling as a potential novel therapeutic target in metabolic disease. Thomas and colleagues overview the metabolic roles of bile acids and discuss approaches to modulate their signalling pathways in the treatment of disorders including obesity, type 2 diabetes, hypertriglyceridaemia and atherosclerosis.

Charles Thomas
Roberto Pellicciari
Kristina Schoonjans
Reviews01 Aug 2008
Nature Reviews Drug Discovery

Volume: 7, P: 678-693
Persistence of Sudanophilic Lipid in Sections of Mummified Tissue

A. T. SANDISON
Research17 Jan 1959
Nature

Volume: 183, P: 196-197
Global chemical effects of the microbiome include new bile-acid conjugations

Metabolomics data from germ-free and specific-pathogen-free mice reveal effects of the microbiome on host chemistry, identifying conjugations of bile acids that are also enriched in patients with inflammatory bowel disease or cystic fibrosis.

Robert A. Quinn
Alexey V. Melnik
Pieter C. Dorrestein
Research26 Feb 2020
Nature

Volume: 579, P: 123-129
Evidence for an essential DNA component in the Scrapie agent

R. F. MARSH
TERRY G. MALONE
R. P. HANSON
Research01 Sept 1978
Nature

Volume: 275, P: 146-147
Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis

During cold stimulation, cholesterol is converted to bile acids in an alternative pathway. The bile acids then alter the microbiota, which in turn promotes more heat generation.

Anna Worthmann
Clara John
Joerg Heeren
Research12 Jun 2017
Nature Medicine

Volume: 23, P: 839-849
Reye's Syndrome: Preservation of Mitochondrial Enzymes in Brain and Muscle Compared with Liver

Brian H Robinson
Jennifer Taylor
D Grant Gall
Research01 Nov 1978
Pediatric Research

Volume: 12, P: 1045-1047
Inhibition of Influenza Virus Multiplication with a Glucose Antimetabolite (2-deoxy-D-glucose)

EDWIN D. KILBOURNE
Research24 Jan 1959
Nature

Volume: 183, P: 271-272
High-speed panoramic light-sheet microscopy reveals global endodermal cell dynamics

Systematic large-scale analysis of embryonic development requires the processing of large amounts of microscopy data. Here Schmid et al.solve this problem by developing a high-speed imaging system that projects zebrafish embryos onto a ‘world map’ in real time, revealing characteristic migration patterns in the early endoderm.

Benjamin Schmid
Gopi Shah
Jan Huisken
ResearchOpen Access25 Jul 2013
Nature Communications

Volume: 4, P: 1-10
Thermal-mechanical properties of a monomolecular film detected by a vibrating reed

R. H. Lacombe
B. M. J. Kellner
Research19 Feb 1981
Nature

Volume: 289, P: 661-662

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