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Showing 1–50 of 71 results

Advanced filters: Author: D G Seidler Clear advanced filters

Synthetic chaperone based on Hsp90-Tau interaction inhibits Tau aggregation and rescues physiological Tau-Microtubule interaction

Tau aggregation, a hallmark of Alzheimer’s disease, disrupts neuron structure. Aging weakens chaperone defenses like Hsp90. This study designs β-Hsp90, a small peptide mimicking Hsp90, to prevent Tau aggregation, offering promise for new amyloid disease drugs.

Davide Di Lorenzo
Nicolo Bisi
Sandrine Ongeri
ResearchOpen Access01 Oct 2025
Nature Communications

Volume: 16, P: 1-18
Electroluminescence in polymer films

David G. Lidzey
Donal D. C. Bradley
Paul F. Seidler
Research13 Mar 1997
Nature

Volume: 386, P: 135
Adaptation of colour vision to sunlight

G. Jordan
J. D. Mollon
Research13 Mar 1997
Nature

Volume: 386, P: 135-136
Neonatal Stress: Effects of Hypoglycemia and Hypoxia on Adrenal Tyrosine Hydroxylase Gene Expression

Joseph D Decristofaro
Edmund F Lagamma
Research01 Dec 1994
Pediatric Research

Volume: 36, P: 719-723
Subnational variations in the quality of household survey data in sub-Saharan Africa

_{Household survey data is vital to health and development. The study describes and maps data quality in 35 African countries, finding that data quality varies and worsens with distance from towns, indicating a need for investment in data collection.}

Valentin Seidler
Edson C. Utazi
Patrick Webb
ResearchOpen Access22 Apr 2025
Nature Communications

Volume: 16, P: 1-12
EPA Developing Methods to Assess Environmental Release

Morris A. Levin
Ramon Seidler
Tamar Barkay
Research01 Jan 1987
Bio/Technology

Volume: 5, P: 38-45
Crystal structure of active elongation factor Tu reveals major domain rearrangements

Harald Berchtold
Ludmila Reshetnikova
Rolf Hilgenfeld
Research09 Sept 1993
Nature

Volume: 365, P: 126-132
Evolutionary transfer of the chloroplast tufA gene to the nucleus

Sandra L. Baldauf
Jeffrey D. Palmer
Research15 Mar 1990
Nature

Volume: 344, P: 262-265
Associative cellulolysis and dinitrogen fixation by co-cultures of Trichoderma harzianum and Clostridium butyricum

D. A. Veal
J. M. Lynch
Research23 Aug 1984
Nature

Volume: 310, P: 695-697
Tapping into truth: an exploratory cross-sectional analysis of psychomotor symptoms and typing behaviour in an adolescent observational cohort

Taylor A. Braund
Debopriyo Bal
Bridianne O’Dea
ResearchOpen Access18 Jun 2025
NPP—Digital Psychiatry and Neuroscience

Volume: 3, P: 1-9
Noradrenaline is essential for mouse fetal development

Steven A. Thomas
Alvin M. Matsumoto
Richard D. Palmiter
Research13 Apr 1995
Nature

Volume: 374, P: 643-646
The SpinBus architecture for scaling spin qubits with electron shuttling

Semiconductor qubit architectures based on direct qubit coupling suffer from wiring fan-out and crosstalk as they scale up. Here the authors propose an architecture based on conveyor-mode shuttling of electron spins that tackles these issues and validate it numerically on quantum dot spin qubits in Si/SiGe.

Matthias Künne
Alexander Willmes
Hendrik Bluhm
ResearchOpen Access11 Jun 2024
Nature Communications

Volume: 15, P: 1-11
Non-canonical functions of SNAIL drive context-specific cancer progression

SNAIL promotes tumour metastasis through inducing epithelial to mesenchymal transition (EMT). Here the authors report that SNAIL bypasses senescence and regulates cell cycle progression to promote pancreatic carcinogenesis and this is independent of EMT induction.

Mariel C. Paul
Christian Schneeweis
Dieter Saur
ResearchOpen Access07 Mar 2023
Nature Communications

Volume: 14, P: 1-21
MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling

Calcineurin signalling or pressure overload is shown to lead to cardiac hypertrophy through NFAT-mediated increase in miR-199. miR-199 inhibits the Dyrk1a kinase, which leads to further activation of NFAT. Inhibition of miR-199 reverses hypertrophy and fibrosis in mouse models of cardiac failure.

Paula A. da Costa Martins
Kanita Salic
Leon J. De Windt
Research21 Nov 2010
Nature Cell Biology

Volume: 12, P: 1220-1227
Affinity capture of proteins from solution and their dissociation by contact printing

André Bernard
Dora Fitzli
Hans Biebuyck
Research01 Sept 2001
Nature Biotechnology

Volume: 19, P: 866-869
The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution

DNA mismatch repair (MMR)-deficient cancers with microsatellite-instability are characterized by a high load of frameshift mutation-derived neoantigens. Here, by mapping the frameshift mutation landscape and predicting the immunogenicity of the resulting peptides, the authors show evidence of immunoediting in MMR-deficient colorectal and endometrial cancers.

Alexej Ballhausen
Moritz Jakob Przybilla
Matthias Kloor
ResearchOpen Access21 Sept 2020
Nature Communications

Volume: 11, P: 1-13
Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2

Specific inhibitors against Hsp90 paralogs show that Hsp90 and Grp94 regulate HER2 in a cell-specific and proteome alteration-driven manner.

Pallav D Patel
Pengrong Yan
Gabriela Chiosis
Research01 Sept 2013
Nature Chemical Biology

Volume: 9, P: 677-684
Effects of Epinephrine on the Renal Vascular Bed of Fetal, Newborn, and Adult Sheep

Kenneth T Nakamura
G Paul Matherne
Jean E Robillard
Research01 Feb 1988
Pediatric Research

Volume: 23, P: 181-186
Global trait–environment relationships of plant communities

Although plant functional trait combinations reflect ecological trade-offs at the species level, little is known about how this translates to whole communities. Here, the authors show that global trait composition is captured by two main dimensions that are only weakly related to macro-environmental drivers.

Helge Bruelheide
Jürgen Dengler
Ute Jandt
Research19 Nov 2018
Nature Ecology & Evolution

Volume: 2, P: 1906-1917
Antibodies targeting Cancer stem cells, A novel pattern in Immunotherapy

Sarfaraz Alam
ResearchOpen Access23 Dec 2010
Nature Precedings

P: 1
White organic light-emitting diodes with fluorescent tube efficiency

Light-emitting diodes based on organic materials (known as OLEDs) have a number of attractive qualities that could make them the light sources of choice for the future. Unfortunately until now they have never reached the power efficiencies of fluorescent tubes. Here, the engineering of white OLEDs with power efficiencies at least as high as that of standard fluorescent tubes brings the future a little closer.

Sebastian Reineke
Frank Lindner
Karl Leo
Research14 May 2009
Nature

Volume: 459, P: 234-238
Structure-based inhibitors of tau aggregation

Tau aggregation is associated with Alzheimer's disease and dozens of related dementias. Now atomic structures of the aggregation-prone segment VQIINK in repeat 2 of tau have been reported. Inhibitors designed using these structures block seeding by full-length tau better than inhibitors that target the VQIVYK aggregation segment in repeat 3.

P. M. Seidler
D. R. Boyer
D. S. Eisenberg
Research20 Nov 2017
Nature Chemistry

Volume: 10, P: 170-176
Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes

Oncogenic dosage variation along distinct evolutionary routes defines fundamental aspects of pancreatic cancer biology and phenotypic diversification.

Sebastian Mueller
Thomas Engleitner
Roland Rad
Research24 Jan 2018
Nature

Volume: 554, P: 62-68
A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer

Roland Rad and colleagues report development of a new conditional piggyBac transposition system for performing insertional mutagenesis screens in mice. They apply the system to identify new oncogenic driver pathways for pancreatic cancer.

Roland Rad
Lena Rad
Allan Bradley
Research08 Dec 2014
Nature Genetics

Volume: 47, P: 47-56
Volatile molecules from bronchoalveolar lavage fluid can ‘rule-in’ Pseudomonas aeruginosa and ‘rule-out’ Staphylococcus aureus infections in cystic fibrosis patients

Mavra Nasir
Heather D. Bean
Jane E. Hill
ResearchOpen Access16 Jan 2018
Scientific Reports

Volume: 8, P: 1-11
Cross-boundary subsidy cascades from oil palm degrade distant tropical forests

The expansion of agriculture and rangelands can cause ecological spillover effects across cultivated-natural ecosystem boundaries. Here, Luskin et al. show irruptions of oil palm-subsidized wild boar alter the abundance and diversity of understory trees >1 km into a primary forest reserve in Malaysia.

Matthew Scott Luskin
Justin S. Brashares
Matthew D. Potts
ResearchOpen Access20 Dec 2017
Nature Communications

Volume: 8, P: 1-7
Disrupting MLC1 and GlialCAM and ClC-2 interactions in leukodystrophy entails glial chloride channel dysfunction

Defects in the cell adhesion molecule GlialCAM, the membrane protein MLC1 and the chloride channel ClC-2 are implicated in leukodystrophy. Here, Hoegg-Beiler et al.show that these proteins form a functional complex to maintain homoeostatic chloride ion transport supporting normal glial function in mice.

Maja B. Hoegg-Beiler
Sònia Sirisi
Thomas J. Jentsch
Research19 Mar 2014
Nature Communications

Volume: 5, P: 1-16
Multitrophic diversity in a biodiverse forest is highly nonlinear across spatial scales

Measurements of biodiversity may differ according to the extent of area sampled, although how this changes across taxa is not well understood. Here, Schuldtet al. find that the diversity of plants, arthropods and microorganisms in a heterogeneous subtropical forest is highly nonlinear across spatial scales.

Andreas Schuldt
Tesfaye Wubet
Helge Bruelheide
ResearchOpen Access10 Dec 2015
Nature Communications

Volume: 6, P: 1-8
A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer

The next generation of genetically engineered mouse models of pancreatic cancer involving a new inducible dual-recombinase system that combines Flp-FRT and Cre-loxP.

Nina Schönhuber
Barbara Seidler
Dieter Saur
Research19 Oct 2014
Nature Medicine

Volume: 20, P: 1340-1347
Size and shape control of a variety of metallic nanostructures using tilted, rotating evaporation and lithographic lift-off techniques

Damien Eschimese
François Vaurette
Steve Arscott
ResearchOpen Access22 May 2019
Scientific Reports

Volume: 9, P: 1-9
Preservation of explicit learning of visuomotor sequences during Parkinson’s disease progression

Eriko Kitahara
Yasushi Shimo
Masanori Nagaoka
ResearchOpen Access09 Jul 2018
Scientific Reports

Volume: 8, P: 1-9
Cross talk between stimulated NF-κB and the tumor suppressor p53

G Schneider
A Henrich
O H Krämer
Research01 Mar 2010
Oncogene

Volume: 29, P: 2795-2806
Room-temperature Bose–Einstein condensation of cavity exciton–polaritons in a polymer

Bose–Einstein condensates of exciton–polaritons have been stabilized in a range of crystalline systems. Now, polaritons are shown to condense at room temperature using a microcavity within an organic polymer.

Johannes D. Plumhof
Thilo Stöferle
Rainer F. Mahrt
Research08 Dec 2013
Nature Materials

Volume: 13, P: 247-252
Viable Legionella pneumophila Not Detectable by Culture on Agar Media

D. Hussong
R. R. Colwell
W. D. Burge
Research01 Sept 1987
Bio/Technology

Volume: 5, P: 947-950
Dynamic changes in perivascular space morphology predict signs of spaceflight-associated neuro-ocular syndrome in bed rest

Sutton B. Richmond
Rachael D. Seidler
Juan Piantino
ResearchOpen Access01 Mar 2024
npj Microgravity

Volume: 10, P: 1-10
Male Rats Exposed to Cocaine in utero Demonstrate Elevated Expression of Fos in the Prefrontal Cortex in Response to Environment

Bret A Morrow
John D Elsworth
Robert H Roth
Research20 Aug 2001
Neuropsychopharmacology

Volume: 26, P: 275-285
LRBA, a BEACH protein mutated in human immune deficiency, is widely expressed in epithelia, exocrine and endocrine glands, and neurons

Eleni Roussa
Pavel Juda
Manfred W. Kilimann
ResearchOpen Access09 May 2024
Scientific Reports

Volume: 14, P: 1-15
A small predatory core genome in the divergent marine Bacteriovorax marinus SJ and the terrestrial Bdellovibrio bacteriovorus

Lisa C Crossman
Huan Chen
O Colin Stine
ResearchOpen Access06 Sept 2012
The ISME Journal

Volume: 7, P: 148-160
In-field validation of automatic blood pressure measuring devices

JE Naschitz
L Gaitini
D Yeshurun
Research08 Feb 2000
Journal of Human Hypertension

Volume: 14, P: 37-42
Circulating Chromogranin A and Catecholamines in Human Fetuses at Uneventful Birth

A Moftaquir-Handaj
F Barbé
M J Boutroy
Research01 Jan 1995
Pediatric Research

Volume: 37, P: 101-105
A postbiotic from Aspergillus oryzae attenuates the impact of heat stress in ectothermic and endothermic organisms

J. D. Kaufman
Y. Seidler
A. G. Ríus
ResearchOpen Access19 Mar 2021
Scientific Reports

Volume: 11, P: 1-13
Retinal maturation is delayed by repeated, but not single, maternal injections of betamethasone in sheep

Julie A Quinlivan
Lyn D Beazley
Sarah A Dunlop
Research01 Jan 2000
Eye

Volume: 14, P: 93-98
Use of job-exposure matrices to estimate occupational exposure to pesticides: A review

Camille Carles
Ghislaine Bouvier
Isabelle Baldi
Reviews18 May 2016
Journal of Exposure Science & Environmental Epidemiology

Volume: 27, P: 125-140
Developmental Effects of Intrauterine Growth Retardation on Cerebral Amino Acid Transport

Olivier Rabin
Jeanne-Marie Lefauconnier
Jean-Marie Bourre
Research01 Jun 1994
Pediatric Research

Volume: 35, P: 640-648
Indigenous Peoples and local communities report ongoing and widespread climate change impacts on local social-ecological systems

Indigenous Peoples and local communities across climate zones and nature dependent livelihoods experience climate change impacts that affect multiple parts of their socioeconomic system, suggests an analysis of 1,661 site-agreed climate change impact reports from 48 locations.

Victoria Reyes-García
David García-del-Amo
Ibrahim S. Zakari
ResearchOpen Access09 Jan 2024
Communications Earth & Environment

Volume: 5, P: 1-10
Molecular Structure, Crystallinity and Morphology of Polyethylene/Polypropylene Blends Studied by Raman Mapping, Scanning Electron Microscopy, Wide Angle X-Ray Diffraction, and Differential Scanning Calorimetry

Tsuyoshi Furukawa
Harumi Sato
Yukihiro Ozaki
Reviews21 Sept 2006
Polymer Journal

Volume: 38, P: 1127-1136
Photocathodes beyond NiO: charge transfer dynamics in a π-conjugated polymer functionalized with Ru photosensitizers

Ruri A. Wahyuono
Bianca Seidler
Benjamin Dietzek
ResearchOpen Access02 Feb 2021
Scientific Reports

Volume: 11, P: 1-13
Daily artificial gravity partially mitigates vestibular processing changes associated with head-down tilt bedrest

G. D. Tays
K. E. Hupfeld
R. D. Seidler
ResearchOpen Access12 Mar 2024
npj Microgravity

Volume: 10, P: 1-10
Adapting SureSelect enrichment protocol to the Ion Torrent S5 platform in molecular diagnostics of craniosynostosis

Ewelina Bukowska-Olech
Delfina Popiel
Aleksander Jamsheer
ResearchOpen Access05 Mar 2020
Scientific Reports

Volume: 10, P: 1-11
Prenatal Nicotine Exposure Impairs Executive Control Signals in Medial Prefrontal Cortex

Daniel W Bryden
Amanda C Burton
Matthew R Roesch
Research20 Jul 2015
Neuropsychopharmacology

Volume: 41, P: 716-725

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