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Pediatric Research (27)
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Showing 1–50 of 106 results

Advanced filters: Author: D H Polk Clear advanced filters

BRCA1 deficiency specific base substitution mutagenesis is dependent on translesion synthesis and regulated by 53BP1

Loss of BRCA1 or BRCA2 results in genomic instability; however most studies have focused on the role of these proteins in double-strand break repair. Here the authors coupled cell line genetics and whole genome sequencing to investigate the formation of base substitutions and short indels in BRCA1-deficient cells, revealing a role for translesion DNA synthesis regulated by 53BP1.

Dan Chen
Judit Z. Gervai
Dávid Szüts
ResearchOpen Access11 Jan 2022
Nature Communications

Volume: 13, P: 1-13
Pathogenic variants reveal candidate genes for prostate cancer germline testing for men of African ancestry

African ancestry is a known risk factor for prostate cancer development, but the genetic determinants of this are incompletely understood. Here, the authors identify 172 potentially pathogenic variants which are enriched in an African population.

Kazzem Gheybi
Pamela X. Y. Soh
Vanessa M. Hayes
ResearchOpen Access02 Oct 2025
Nature Communications

Volume: 16, P: 1-16
Primordial germ cell DNA demethylation and development require DNA translesion synthesis

Here the authors show that DNA translesion synthesis affects primordial germ cell DNA demethylation and plays a role in the development of embryonic germ cells.

Pranay Shah
Ross Hill
Gerry P. Crossan
ResearchOpen Access03 May 2024
Nature Communications

Volume: 15, P: 1-20
Characterization of promoter regulatory elements involved in downexpression of the DNA polymerase κ in colorectal cancer

F Lemée
C Bavoux
C Cazaux
Research13 Nov 2006
Oncogene

Volume: 26, P: 3387-3394
RNA sequestration in P-bodies sustains myeloid leukaemia

Kodali, Proietti et al. report that increased numbers of P-bodies in leukaemia cells account for sequestration and prevention of tumour-suppressive mRNAs from being translated, which could be targeted as a potential intervention in myeloid leukaemia.

Srikanth Kodali
Ludovica Proietti
Bruno Di Stefano
Research21 Aug 2024
Nature Cell Biology

Volume: 26, P: 1745-1758
Effect of Fetal Thyroidectomy on Newborn Thermogenesis in Lambs

D H Polk
C C Callegari
A H Klein
Research01 May 1987
Pediatric Research

Volume: 21, P: 453-457
DNA polymerases and cancer

DNA polymerases have various roles from DNA replication to tolerating DNA damage through a process known as translesion DNA synthesis. This Review discusses the function of the DNA polymerase family and their possible roles in cancer.

Sabine S. Lange
Kei-ichi Takata
Richard D. Wood
Reviews24 Jan 2011
Nature Reviews Cancer

Volume: 11, P: 96-110
Local structure of silicate glasses

G. N. Greaves
A. Fontaine
S. J. Gurman
Research22 Oct 1981
Nature

Volume: 293, P: 611-616
Multi-ancestry polygenic mechanisms of type 2 diabetes

A multi-ancestry analysis in large cohorts of patients with type 2 diabetes (T2D) identified 12 disease genetic clusters with distinct cardiometabolic trait associations, including two lipodystrophy-related clusters that could provide insights on the increased T2D susceptibility in East Asian ancestries at a given body mass index level.

Kirk Smith
Aaron J. Deutsch
Miriam S. Udler
Research05 Mar 2024
Nature Medicine

Volume: 30, P: 1065-1074
Non-invasive bird tagging

Delphine Michard
André Ancel
Géarard Wey
Research24 Aug 1995
Nature

Volume: 376, P: 649-650
Eating disorder symptoms and emotional arousal modulate food biases during reward learning in females

Disordered eating can disrupt the rewarding value of food. Here, the authors show in a female sample that eating disorder symptoms, emotional arousal, and interoceptive awareness modulate goal-irrelevant food biases during reinforcement learning.

Nina Rouhani
Cooper D. Grossman
Anita Tusche
ResearchOpen Access26 Mar 2025
Nature Communications

Volume: 16, P: 1-14
Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor

Keith Wilson
D. Brent Polk
Tianhui Hu
ResearchOpen Access21 Sept 2011
Nature Precedings

P: 1
Investigative needle core biopsies support multimodal deep-data generation in glioblastoma

Stereotactic needle biopsies are currently performed for diagnosis only in glioblastoma; this study highlights the depth of information available through multi-omics analysis.

Kenny K. H. Yu
Sreyashi Basu
Nathalie Y. R. Agar
ResearchOpen Access28 Apr 2025
Nature Communications

Volume: 16, P: 1-23
Deoxyribonucleic Acid and the Ancestry of Wheat

M. D. UPADHYA
M. S. SWAMINATHAN
Research16 Nov 1963
Nature

Volume: 200, P: 713-714
Reversible Umbilical Cord Occlusion: Effects on Thermogenesis In Utero

Tania R Gunn
Karen T Ball
Peter D Gluckman
Research01 Dec 1991
Pediatric Research

Volume: 30, P: 513-517
Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury

Christian Woiciechowsky
Khusru Asadullah
Wolf-Diatrich Döcke
Research01 Jul 1998
Nature Medicine

Volume: 4, P: 808-813
Ovine Fetal-Maternal Water Transfer is Independent of Fetal Prolactin Levels

Rosemary D Leake
M Gore Ervin
Delbert A Fisher
Research01 Oct 1985
Pediatric Research

Volume: 19, P: 986-988
A PCR–based approach for isolating pathogen resistance genes from potato with potential for wide application in plants

Dario Leister
Agim Ballvora
Christiane Gebhardt
Research01 Dec 1996
Nature Genetics

Volume: 14, P: 421-429
Common germline-somatic variant interactions in advanced urothelial cancer

The role of germline variation in human cancers is not fully understood. Here, the authors define the landscape of putative deleterious germline variants that abrogate tumor suppressor proteins in advanced urothelial cancer patients.

Aram Vosoughi
Tuo Zhang
Bishoy M. Faltas
ResearchOpen Access03 Dec 2020
Nature Communications

Volume: 11, P: 1-13
A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine

The association between blood pressure (BP) and migraine is poorly understood. Here, the authors explore this relationship using summary-level GWAS data for BP and migraine. Cross-trait meta-analysis reveals shared loci between BP and migraine, while Mendelian randomization suggests that diastolic BP specifically plays a key role in migraine susceptibility.

Yanjun Guo
Pamela M. Rist
Daniel I. Chasman
ResearchOpen Access06 Jul 2020
Nature Communications

Volume: 11, P: 1-11
GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Genome-wide analyses identify common variants associated with 11 distinct neuropathology endophenotypes, providing insights into the mechanisms underlying the genetic risk of Alzheimer’s disease and related dementias.

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
ResearchOpen Access08 Oct 2024
Nature Genetics

Volume: 56, P: 2407-2421
Lightning as Background Noise for Communication among Electric Fish

C. D. HOPKINS
Research23 Mar 1973
Nature

Volume: 242, P: 268-270
Noise-induced enhancement of signal transduction across voltage-dependent ion channels

Sergey M. Bezrukov
Igor Vodyanoy
Research01 Nov 1995
Nature

Volume: 378, P: 362-364
AMYOPLASIA: AUTOSOMAL RECESSIVE INHERITANCE IN TWO FAMILIES

Daniel H Polk
Robin D Clark
Larry Shapiro
Research01 Apr 1987
Pediatric Research

Volume: 21, P: 229
Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection

The response to infectious and inflammatory challenges differs among people but the reasons for this are poorly understood. Here the authors explore the impact of variables such as age, sex, and the capacity for controlling inflammation and maintaining immunocompetence, linking this capacity to favourable health outcomes and lifespan.

Sunil K. Ahuja
Muthu Saravanan Manoharan
Weijing He
ResearchOpen Access13 Jun 2023
Nature Communications

Volume: 14, P: 1-31
Changes in Ovine Hepatic Circulation and Oxygen Consumption at Birth

Susan F Townsend
Colin D Rudolph
Abraham M Rudolph
Research01 Mar 1989
Pediatric Research

Volume: 25, P: 300-304
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
A scoping review of remote and unsupervised digital cognitive assessments in preclinical Alzheimer’s disease

Sarah E. Polk
Fredrik Öhman
David Berron
ResearchOpen Access10 May 2025
npj Digital Medicine

Volume: 8, P: 1-14
Ontogeny of Atrial Natriuretic Factor Receptors and Cyclic GMP Response in Rabbit Renal Glomeruli

Robert Castro
Rosemary D Leake
Delbert A Fisher
Research01 Jul 1991
Pediatric Research

Volume: 30, P: 45-49
EFFECT OF FETAL THYROIDECTOMY ON THE METABOLIC RESPONSE TO BIRTH IN LAMBS

D H Polk
J F Padbury
A H Klein
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 174
301 SOMATOMEDIN-C (SM-C) LEVELS IN FETAL SHEEP ARE INDEPENDENT OF SERUM PLACENTAL LACTOGEN LEVELS

D H Polk
R W Lam
D A Fisher
Research01 Apr 1985
Pediatric Research

Volume: 19, P: 161
Climate suitability of the Mediterranean Basin for citrus black spot disease (Phyllosticta citricarpa) based on a generic infection model

Anaïs Galvañ
Naima Boughalleb-M’Hamdi
Antonio Vicent
ResearchOpen Access18 Nov 2022
Scientific Reports

Volume: 12, P: 1-16
Author Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
Amendments and CorrectionsOpen Access17 Jun 2025
Nature Genetics

Volume: 57, P: 1788
AUTOIMMUNE SYMPATHECTOMY IN FETAL RABBITS

J F Padbury
D H Polk
R W Lam
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 143
Publisher Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
Amendments and CorrectionsOpen Access17 Jun 2025
Nature Genetics

Volume: 57, P: 1791
The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance

Using multimodal MRI to delineate noradrenergic and dopaminergic nuclei in aging, Dahl et al. found differential associations with episodic and working memory, helping to disentangle the role of the neurotransmitter systems in age-related memory loss.

Martin J. Dahl
Shelby L. Bachman
Mara Mather
ResearchOpen Access31 Aug 2023
Nature Aging

Volume: 3, P: 1128-1143
Cancer of the cervix uteri and vitamin A

R W Harris
D Forman
N J Wald
Research01 May 1986
British Journal of Cancer

Volume: 53, P: 653-659
Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses

Sindy H Wei
Hugh Rosen
Michael D Cahalan
Research06 Nov 2005
Nature Immunology

Volume: 6, P: 1228-1235
Cancer drug-tolerant persister cells: from biological questions to clinical opportunities

Resistance to therapy remains the biggest challenge to achieving cures in patients with cancer. In this Roadmap, Russo et al. overview the field of cancer drug-tolerant persister cells providing paths to advance our understanding of their biology with innovative technologies and recommend strategies to therapeutically target them to ensure that more prolonged responses are achieved in patients with cancer.

Mariangela Russo
Mengnuo Chen
Alberto Bardelli
Reviews02 Sept 2024
Nature Reviews Cancer

Volume: 24, P: 694-717
Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways

Nephritis is a major cause of lupus morbidity. Putterman and colleagues use single-cell RNA sequencing on human renal and skin biopsies to describe the expression landscape associated with lupus nephritis.

Evan Der
Hemant Suryawanshi
Fan Zhang
Research20 May 2019
Nature Immunology

Volume: 20, P: 915-927
PRETERM OVINE CATECHOLAMINE RESPONSE TO UMBILICAL CORD CUTTING

D H Polk
J F Padbury
D A Fisher
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 367
1049 REACTOGENICITY AND IMMUNOGENICITY OF PERTUSSIS VACCINE COMPONENTS

M D Murphy
J Rasnack
P Brunell
Research01 Apr 1981
Pediatric Research

Volume: 15, P: 617
1048 RAPID VIRAL DIAGNOSIS IN AN OUTPATIENT LABORATORY

M D Murphy
G Macias
P Brunell
Research01 Apr 1981
Pediatric Research

Volume: 15, P: 617
SOMATOMEDIN C IN PRECOCIOUS PUBERTY

Ora H Pescovitz
Florence Omite
Ron G Rosenfeldt
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 174
Antibacterial FANA oligonucleotides as a novel approach for managing the Huanglongbing pathosystem

Andrés F. Sandoval-Mojica
Wayne B. Hunter
Kirsten S. Pelz-Stelinski
ResearchOpen Access02 Feb 2021
Scientific Reports

Volume: 11, P: 1-11
INSULIN RECEPTOR (IR) DEVELOPMENT IN NORMAL (N) AND DIABETIC (D) PREGNANCIES: DOES INSULIN (I) UP REGULATE THE RECEPTOR?

Naomi D Neufeld
L Corbo
S Brunnerman
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 143
Semi-field and surveillance data define the natural diapause timeline for Culex pipiens across the United States

The combination of laboratory and semifield experiments, paired with surveillance data, demonstrate the natural timeline for mosquito diapause, highlighting the importance of latitude and population genetics.

Eleanor N. Field
John J. Shepard
Ryan C. Smith
ResearchOpen Access27 Nov 2022
Communications Biology

Volume: 5, P: 1-12
299 NEONATAL ADAPTATION: SYMPATHOADRENAL AND ENDORPHIN (END) RESPONSES TO DELIVERY IN TERM AND PRETERM LAMBS

J F Padbury
Y Ogata
R W Lam
Research01 Apr 1985
Pediatric Research

Volume: 19, P: 160
Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P₁ antagonist in vivo

M Germana Sanna
Sheng-Kai Wang
Hugh Rosen
Research09 Jul 2006
Nature Chemical Biology

Volume: 2, P: 434-441
Detection of prions from spiked and free-ranging carnivore feces

H. N. Inzalaco
E. E. Brandell
W. C. Turner
ResearchOpen Access15 Feb 2024
Scientific Reports

Volume: 14, P: 1-12

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