Nature Search

Deep learning to diagnose Hashimoto’s thyroiditis from sonographic images

Hashimoto’s thyroiditis (HT) is the main cause of hypothyroidism. Here the authors develop a deep learning model for diagnosis of HT on a large multi-site dataset including image and video data.

Qiang Zhang
Sheng Zhang
Xiangchun Li
ResearchOpen Access29 Jun 2022
Nature Communications

Volume: 13, P: 1-8
EFFECT OF THYROID HORMONE TREATMENT ON THYROMEGALY IN CHILDREN AND ADOLESCENTS WITH HASHIMOTO'S THYROIDITIS

K I Rother
D Zimmerman
W F Schwenk
Research01 May 1993
Pediatric Research

Volume: 33, P: S92
Host control of persistent Epstein–Barr virus infection

Axel Schmidt
T. Madhusankha Alawathurage
Kerstin U. Ludwig
Research19 Feb 2026
Nature

P: 1-5
Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves’ disease

A A Zeitlin
J M Heward
M J Simmonds
Research01 May 2008
Genes & Immunity

Volume: 9, P: 358-363
Distinct histopathological features of Hashimoto’s thyroiditis with respect to IgG4-related disease

Yaqiong Li
Gengyin Zhou
Kennichi Kakudo
Research04 May 2012
Modern Pathology

Volume: 25, P: 1086-1097
Turner Syndrome and Hashimoto Thyroiditis Association: the Prevalence in 75 Cases

D B Marmo
G Guerra Jr
S HVL Marini
News01 Feb 1997
Pediatric Research

Volume: 41, P: 305
Spontaneous globe luxation and floppy eyelid syndrome in a patient with Hashimoto's disease

R Reyniers
D Paridaens
Correspondence22 Sept 2006
Eye

Volume: 21, P: 303-304
Fecal microbiota transplantation plus immunotherapy in non-small cell lung cancer and melanoma: the phase 2 FMT-LUMINate trial

In a phase 2 trial evaluating healthy donor fecal microbial transplantation plus either anti-PD-1 in patients with non-small cell lung cancer or anti-PD-1 and anti-CTLA-4 in patients with melanoma, encouraging efficacy was seen in both cohorts, with responses linked to significantly greater loss of baseline bacterial species.

Sreya Duttagupta
Meriem Messaoudene
Arielle Elkrief
ResearchOpen Access28 Jan 2026
Nature Medicine

P: 1-14
Autoimmune thyroid disease: new models of cell death in autoimmunity

Giorgio Stassi
Ruggero De Maria
Reviews01 Mar 2002
Nature Reviews Immunology

Volume: 2, P: 195-204
Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing

Information on immune receptor repertoire provides important insights on disease progression and therapy development, but can be expensive and time-consuming to obtain. Here the authors report ImReP, a computational method that can extract detailed immune repertoire information from existing tissue-specific RNA sequencing data.

Igor Mandric
Jeremy Rotman
Serghei Mangul
ResearchOpen Access19 Jun 2020
Nature Communications

Volume: 11, P: 1-14
CXCR4 induces memory formation over exhaustion in CAR-T cells to achieve durable leukemia targeting

CAR-T cell efficacy is often limited by the inability to maintain a memory T cell program. Here, the authors show that intrinsic CXCR4 expression enhances CAR-T cell persistence and memory differentiation in acute myeloid leukemia.

Ari Itoh-Nakadai
Minggao Liang
Fumihiko Ishikawa
ResearchOpen Access26 Jan 2026
Nature Communications

Volume: 17, P: 1-21
Aerobic Respiration in Soil Crumbs

D. J. GREENWOOD
G. BERRY
Research14 Jul 1962
Nature

Volume: 195, P: 161-163
Start codon variant in LAG3 is associated with decreased LAG-3 expression and increased risk of autoimmune thyroid disease

Here, the authors conduct a GWAS for autoimmune thyroid disease, finding 225 loci including a start codon variant in LAG3 that confers a 3.4-fold risk of autoimmune thyroid disease and reduces expression and plasma levels of LAG−3.

Saedis Saevarsdottir
Kristbjörg Bjarnadottir
Kari Stefansson
ResearchOpen Access09 Jul 2024
Nature Communications

Volume: 15, P: 1-12
Observation of Dislocations in Metals by Means of Moiré Patterns on Electron Micrographs

D. W. PASHLEY
J. W. MENTER
G. A. BASSETT
Research13 Apr 1957
Nature

Volume: 179, P: 752-755
An ‘Auto-Immune’ Reaction Against Human Tissue Antigens in Certain Chronic Diseases

D. CARLETON GAJDUSEK
Research30 Mar 1957
Nature

Volume: 179, P: 666-668
Universal tree of life

Mitchell L. Sogin
Gregory Hinkle
Detlef D. Leipe
Research29 Apr 1993
Nature

Volume: 362, P: 795
Universal tree of life

Patrick Forterre
Nadia Benachenhou-Lafha
Bernard Labedan
Research29 Apr 1993
Nature

Volume: 362, P: 795
Dispersal via whale bones

D. M. MARTILL
A. R. I. CRUICKSHANK
M. A. TAYLOR
Research16 May 1991
Nature

Volume: 351, P: 193
The Special Theory of Electromagnetism

B. L. COLEMAN
Research11 Feb 1961
Nature

Volume: 189, P: 476-477
The puzzling Venusian polar atmospheric structure reproduced by a general circulation model

Unlike some planets, the Venusian polar vortex is warmer than the mid-latitudes at cloud-top level, but the mechanism behind this is unknown. Here, the authors use a general circulation model and suggest the cold collar and warm polar regions are due to residual mean meridional circulation intensified by thermal tides.

Hiroki Ando
Norihiko Sugimoto
Yoshihisa Matsuda
ResearchOpen Access01 Feb 2016
Nature Communications

Volume: 7, P: 1-8
Generative modeling of single-cell time series with PRESCIENT enables prediction of cell trajectories with interventions

Single-cell RNA-Seq allows us to observe snapshots of how biological systems change over time at cellular resolution. Here, the authors develop a generative framework that uses time-resolved single-cell data to model how cells change in physical time, including in response to perturbations.

Grace Hui Ting Yeo
Sachit D. Saksena
David K. Gifford
ResearchOpen Access28 May 2021
Nature Communications

Volume: 12, P: 1-12
Diffusion Studies of Bovine Serum Albumin with Jamin Interference Optics and Micro-Diffusion Cell

AMALA CHATTERJEE
Research16 Jun 1962
Nature

Volume: 194, P: 1053-1054
Dynamic competition between spin-density wave order and superconductivity in underdoped Ba_1−xK_xFe₂As₂

Whether superconductivity coexists or competes with other types of order in unconventional superconductors is a question that has been hotly contested. An ARPES study reported by Yi et al. suggest that superconductivity and spin-density wave orders coexist and compete dynamically in Ba_1−xK_xFe₂As₂.

M. Yi
Y. Zhang
D.H. Lu
Research25 Apr 2014
Nature Communications

Volume: 5, P: 1-7
A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities

Yuta Kochi
Ryo Yamada
Kazuhiko Yamamoto
Research17 Apr 2005
Nature Genetics

Volume: 37, P: 478-485
A non-spike nucleocapsid R204P mutation in SARS-CoV-2 Omicron XEC enhances inflammation and pathogenicity

SARS-CoV-2 Omicron XEC variant, a recombinant of JN.1 progeny, shows increased viral fitness and pathogenicity. Here, the authors show that the nucleocapsid mutation R204P enhances inflammation and suggest a growing role of non-spike mutations in viral evolution.

Shuhei Tsujino
Masumi Tsuda
Miki Kawano
ResearchOpen Access14 Dec 2025
Nature Communications

Volume: 17, P: 1-13
Intrusion of basaltic sills into highly porous sediments, and resulting hydrothermal activity

Gerhardt Einsele
Joris M. Gieskes
Victor Vacquier
Research31 Jan 1980
Nature

Volume: 283, P: 441-445
Dynamic observation of defect annealing in CdTe at lattice resolution

R. Sinclair
F. A. Ponce
C. J. D. Catto
Research08 Jul 1982
Nature

Volume: 298, P: 127-131
Ca²⁺-driven PDIA6 biomolecular condensation ensures proinsulin folding

Lee et al. show that Ca²⁺ triggers condensates enriched with PDIA6, an ER-resident disulfide isomerase and chaperone, along with other protein disulfide isomerase family proteins and some chaperones that in turn enhance folding of proinsulin.

Young-Ho Lee
Tomohide Saio
Masaki Okumura
ResearchOpen Access11 Nov 2025
Nature Cell Biology

Volume: 27, P: 1952-1964
Superconducting gap anisotropy sensitive to nematic domains in FeSe

The superconducting gap structure of FeSe remains a debated issue. Here, Hashimoto et al. report momentum dependence of the gap in single- and multi-domain regions of orthorhombic FeSe crystals, revealing an unusual node lifting of the gap structure in multi-domain regions.

Takahiro Hashimoto
Yuichi Ota
Shik Shin
ResearchOpen Access18 Jan 2018
Nature Communications

Volume: 9, P: 1-7
When the action is “hybrid”–ethical challenges of the emerging technologies in the operating room

Luca Valera
María Jesús Irarrázaval
Mauricio Gabrielli
ResearchOpen Access05 Feb 2026
Humanities and Social Sciences Communications

Volume: 13, P: 1-10
A multicenter cohort study of thyroidectomy-related decision regret in patients with low-risk papillary thyroid microcarcinoma

Thyroidectomy is frequently the treatment offered to patients with low-risk papillary thyroid microcarcinoma (PTMC). Here, the authors perform a multicentre online survey to a cohort of patients with PTMC showing that heightened regret may not be an experience of a minority of clinically low-risk PTMC patients and is primarily due to lower postoperative quality of life.

Genpeng Li
Ruicen Li
Jianyong Lei
ResearchOpen Access08 Mar 2025
Nature Communications

Volume: 16, P: 1-11
Thyroid growth-blocking antibodies in primary myxoedema

H. A. Drexhage
G. F. Bottazzo
D. Doniach
Research12 Feb 1981
Nature

Volume: 289, P: 594-596
Sex-specific associations between maternal prenatal and postnatal psychological distress and autism spectrum disorder in the Japan Environment and Children’s Study

Hidekazu Nishigori
Toshie Nishigori
Kimitoshi Nakamura
ResearchOpen Access02 Feb 2026
Scientific Reports

Volume: 16, P: 1-12
Structural basis of cyclobutane pyrimidine dimer recognition by UV-DDB in the nucleosome

UV-DDB is a protein that plays a key role in recognizing DNA lesions. Here, the authors determine the cryo-EM structure of UV-DDB bound to UV-damaged chromatin in human cells, identifying a nucleosome binding site.

Syota Matsumoto
Yoshimasa Takizawa
Hitoshi Kurumizaka
ResearchOpen Access11 Nov 2025
Nature Communications

Volume: 16, P: 1-11
Metabolic Activity of Monolayer Tissue Cultures of Human Thyroid

E. S. K. ASSEM
Research10 Jul 1965
Nature

Volume: 207, P: 191-192
Vitamin D and autoimmune thyroid diseases

Shaye Kivity
Nancy Agmon-Levin
Yehuda Shoenfeld
Research31 Jan 2011
Cellular & Molecular Immunology

Volume: 8, P: 243-247
Syntheses and immunological evaluation of bovine proinsulin C-peptide analogues

N. YANAIHARA
N. SAKURA
D. F. STEINER
Research27 Nov 1975
Nature

Volume: 258, P: 365-366
Human organoids as 3D in vitro platforms for drug discovery: opportunities and challenges

Human organoids provide physiologically relevant, 3D models for studying disease mechanisms, drug efficacy and toxicity. This Review examines organoid generation methods, applications in preclinical drug discovery, and the regulatory and practical challenges that must be addressed for their integration into development pipelines.

Daisong Wang
Remi Villenave
Hans Clevers
Reviews12 Nov 2025
Nature Reviews Drug Discovery

P: 1-23
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Observation of universal strong orbital-dependent correlation effects in iron chalcogenides

A proper theoretical description for unconventional superconductivity in iron-based compounds remains elusive. Here, the authors, to capture the electron correlation strength and the role of Fermi surfaces, report ARPES measurements of three iron chalcogenide superconductors to establish universal features.

M. Yi
Z-K Liu
D.H. Lu
ResearchOpen Access23 Jul 2015
Nature Communications

Volume: 6, P: 1-7
New Pathways in the Oxidative Metabolism of Aromatic Compounds by Micro-Organisms

S. DAGLEY
W. CHARLES EVANS
D. W. RIBBONS
Research12 Nov 1960
Nature

Volume: 188, P: 560-566
Heterotopic Calcification of Human Nail and Hair

P. R. BLAKEY
C. EARLAND
D. SWIFT
Research10 Jul 1965
Nature

Volume: 207, P: 190-191
Separation of the 3,5-Dinitrobenzoates of Volatile Alcohols by Paper Chromatography

D. F. MEIGH
Research26 Apr 1952
Nature

Volume: 169, P: 706-707
The gene for Machado–Joseph disease maps to human chromosome 14q

Y. Takiyama
M. Nishizawa
S. Tsuji
Research01 Jul 1993
Nature Genetics

Volume: 4, P: 300-304
Degradation of the Benzene Nucleus by Bacteria

S. DAGLEY
P. J. CHAPMAN
J. M. WOOD
Research23 May 1964
Nature

Volume: 202, P: 775-778
Thyroglobulin Messenger Ribonucleic Acid Levels in the Peripheral Blood of Children with Benign and Malignant Thyroid Disease

Cydney Fenton
Jeffrey S Anderson
Gary L Francis
Research01 Mar 2001
Pediatric Research

Volume: 49, P: 429-434
Extra-neuronal Sodium Store in Central Nervous System of Anodonta cygnea

J. E. TREHERNE
ALBERT D. CARLSON
B. L. GUPTA
Research26 Jul 1969
Nature

Volume: 223, P: 377-380
Terminal Distribution in the Superior Colliculus of Fibres Originating in the Visual Cortex

R. D. LUND
Research26 Dec 1964
Nature

Volume: 204, P: 1283-1285
A spatial emergent constraint on the sensitivity of soil carbon turnover to global warming

The fate of the carbon locked away in soil is uncertain, and there are vast differences between models. Here the authors apply observational, spatio-temporal constraints on carbon turnover projections and find that uncertainty in estimations of carbon dynamics are reduced by 50%.

Rebecca M. Varney
Sarah E. Chadburn
Peter M. Cox
ResearchOpen Access02 Nov 2020
Nature Communications

Volume: 11, P: 1-8
A gene for hereditary haemorrhagic telangiectasia maps to chromosome 9q3

Claire L. Shovlin
J.M.B. Hughes
J.G. Seidman
Research01 Feb 1994
Nature Genetics

Volume: 6, P: 205-209

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