Recent studies have shown that neutrophil extracellular traps (NETs) can capture and kill bacteria but may also contribute to chronic inflammation. The mechanisms that trigger NET formation are not yet fully elucidated. Marcos et al. now report that stimulation of the chemokine receptor CXCR, induces NET formation and that NETs are present in airway fluids of individuals with cystic fibrosis. Blocking CXCR2 activation in the lung reduced NET formation and improved lung function in a mouse model of cystic fibrosis.
- Veronica Marcos
- Zhe Zhou
- Dominik Hartl
