Nature Search

Effect of Indomethacin on Cerebral Oxidized Cytochrome Oxidase in Preterm Infants

D C Mccormick
A D Edwards
E O R Reynolds
Research01 Jun 1993
Pediatric Research

Volume: 33, P: 603-608
Production of Lymphotoxin and Tumor Necrosis Factor by Human Neonatal Mononuclear Cells

B Keith English
Sandra K Burchett
Christopher B Wilson
Research01 Dec 1988
Pediatric Research

Volume: 24, P: 717-722
Immune response to SARS-CoV-2 variants of concern in vaccinated individuals

Here, the authors characterize the antibody response from vaccinated (Pfizer BNT-162b2), infected and uninfected individuals against emerging variants of concern of SARS-CoV-2, finding reduced neutralization of a South African isolate. High IgG titers in the saliva of vaccinees suggest that transmission may be reduced.

Matthias Becker
Alex Dulovic
Nicole Schneiderhan-Marra
ResearchOpen Access25 May 2021
Nature Communications

Volume: 12, P: 1-8
Activation of the Plasma Kallikrein-Kinin System in Respiratory Distress Syndrome

Ola D Saugstad
Laila Buø
Ansgar O Aasen
Research01 Oct 1992
Pediatric Research

Volume: 32, P: 431-435
The Effect of Exocrine Pancreatic Function on Chloramphenicol Pharmacokinetics in Patients with Cystic Fibrosis

Chris J Dickinson
Michael D Reed
Jeffrey L Blumer
Research01 Apr 1988
Pediatric Research

Volume: 23, P: 388-392
Decline of Exocrine Pancreatic Function in Cystic Fibrosis Patients with Pancreatic Sufficiency

R T L Couper
M Corey
P R Durie
Research01 Aug 1992
Pediatric Research

Volume: 32, P: 179-182
Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia

Robert Hegele and colleagues report a genome-wide association study for hypertriglyceridemia, followed by resequencing of the coding regions of candidate genes. They identify an excess of rare variants in affected individuals at four genes within the associated loci.

Christopher T Johansen
Jian Wang
Robert A Hegele
Research25 Jul 2010
Nature Genetics

Volume: 42, P: 684-687
Molecular engineering of safe and efficacious oral basal insulin

Recently, the first orally-administered ultra-long acting insulin was shown to have clinical efficacy. Here, the authors report the molecular engineering, as well as the biological and pharmacological properties of these insulin analogues.

Frantisek Hubálek
Hanne H. F. Refsgaard
Thomas Kjeldsen
ResearchOpen Access27 Jul 2020
Nature Communications

Volume: 11, P: 1-9
Increased Kallikrein Content of Saliva from Patients with Cystic Fibrosis of the Pancreas: A Theory for the Pathogenesis of Abnormal Secretions

Jack Lieberman
Glenn D Littenberg
Research01 Nov 1969
Pediatric Research

Volume: 3, P: 571-578
Acceleration of Growth Rate in Growth Hormone-Deficient Children Treated with Human Growth Hormone-Releasing Hormone

Michael O Thorner
Alan D Rogol
Charles Brook
Research01 Aug 1988
Pediatric Research

Volume: 24, P: 145-151
Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing

Cell cycle and replication need to be tightly regulated to ensure genome stability in mammalian cells. Here the authors provide a link between chromatin structure and DNA replication regulation by showing that chromatin compaction limits replication licensing thereby promoting genome integrity.

Muhammad Shoaib
David Walter
Claus S. Sørensen
ResearchOpen Access12 Sept 2018
Nature Communications

Volume: 9, P: 1-11
Rapid planetesimal formation in turbulent circumstellar disks

Anders Johansen
Jeffrey S. Oishi
Andrew Youdin
Research30 Aug 2007
Nature

Volume: 448, P: 1022-1025
Dynamical prefrontal population coding during defensive behaviours

Dorsomedial prefrontal cortex represents threat and defensive action initiation, and the dynamic interplay between those representations dictates the temporal evolution of avoidance response to threats.

Daniel Jercog
Nanci Winke
Cyril Herry
Research14 Jul 2021
Nature

Volume: 595, P: 690-694
Memory formation in the absence of experience

Pairing an odor conditioned stimulus (CS) with an unconditioned stimulus (US) induces memory formation. Vetere et al. replace the real CS and US with direct optogenetic stimulation of the brain and create a fully artificial odor memory in mice.

Gisella Vetere
Lina M. Tran
Paul W. Frankland
Research29 Apr 2019
Nature Neuroscience

Volume: 22, P: 933-940
Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

Impaired TGF-β signaling due to SMAD4 mutation in PDAC tumors initiates a STAT3-dependent signaling cascade that leads to increased stromal stiffening and disease progression.

Hanane Laklai
Yekaterina A Miroshnikova
Valerie M Weaver
Research18 Apr 2016
Nature Medicine

Volume: 22, P: 497-505
Microglia innately develop within cerebral organoids

Brain organoid models reported to date lack cells of mesodermal origin, such as microglia. Here, the authors demonstrate that mature microglia-like cells are generated within their cerebral organoid model, providing new avenues for studying human microglia in a three-dimensional brain environment.

Paul R. Ormel
Renata Vieira de Sá
R. Jeroen Pasterkamp
ResearchOpen Access09 Oct 2018
Nature Communications

Volume: 9, P: 1-14
Effect of a long-acting somatostatin analogue (BIM23014) on proliferative diabetic retinopathy: A pilot study

M McCombe
S Lightman
S L Lightman
Research01 Sept 1991
Eye

Volume: 5, P: 569-575
Mobile phones and malignant melanoma of the eye

C Johansen
J D Boice Jr
J H Olsen
ResearchOpen Access11 Feb 2002
British Journal of Cancer

Volume: 86, P: 348-349
Histone H4 lysine 20 mono-methylation directly facilitates chromatin openness and promotes transcription of housekeeping genes

The effect of histone H4 lysine 20 methylation (H4K20me) on chromatin accessibility are not well established. Here the authors show how H4K20 methylation regulates chromatin structure and accessibility to ensure precise transcriptional outputs through the cell cycle using genome-wide approaches, in vitro biophysical assays, and NMR.

Muhammad Shoaib
Qinming Chen
Claus S. Sørensen
ResearchOpen Access20 Aug 2021
Nature Communications

Volume: 12, P: 1-16
AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy

AMPK integrates information about a cell’s energy status to inform decisions about cellular processes, including autophagy. Here the authors identify cyclin Y as an AMPK substrate, which phosphorylates cyclin Y and promotes its interaction with CDK16 to stimulate autophagy.

Marc Dohmen
Sarah Krieg
Jörg Vervoorts
ResearchOpen Access25 Feb 2020
Nature Communications

Volume: 11, P: 1-18
Fertility studies in the broad bean (Vicia faba L.)

D G Rowlands
Research01 May 1964
Heredity

Volume: 19, P: 271-277
ADRA1A–Gα_q signalling potentiates adipocyte thermogenesis through CKB and TNAP

Rahbani et al. show that the α₁-adrenergic receptor potentiates thermogenesis in thermogenic adipocytes, acting via Gα_q signalling, creatine kinase B and tissue-non-specific alkaline phosphatase.

Janane F. Rahbani
Charlotte Scholtes
Lawrence Kazak
ResearchOpen Access07 Nov 2022
Nature Metabolism

Volume: 4, P: 1459-1473
Piscine orthoreovirus demonstrates high infectivity but low virulence in Atlantic salmon of Pacific Canada

Mark P. Polinski
Gary D. Marty
Kyle A. Garver
ResearchOpen Access13 Mar 2019
Scientific Reports

Volume: 9, P: 1-22
Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV

The analysis of multiple SIV vaccine regimens in macaques leads to the identification of a key two-amino-acid signature that confers resistance to neutralizing antibodies; a similar mechanism of immune escape is shown to operate in HIV and may explain the limited efficacy seen in HIV vaccine trials.

Mario Roederer
Brandon F. Keele
John R. Mascola
Research18 Dec 2013
Nature

Volume: 505, P: 502-508
ATG5 overexpression is neuroprotective and attenuates cytoskeletal and vesicle-trafficking alterations in axotomized motoneurons

Tatiana Leiva-Rodríguez
David Romeo-Guitart
Caty Casas
ResearchOpen Access24 May 2018
Cell Death & Disease

Volume: 9, P: 1-17
Absence of mutations in the ATM gene in breast cancer patients with severe responses to radiotherapy

JM Appleby
JBP Barber
D Scott
Research01 Dec 1997
British Journal of Cancer

Volume: 76, P: 1546-1549
NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity

Autophagosome biogenesis depends on the lipid kinase Vps34 and its binding proteins Beclin 1 and Atg14L. Lu et al.identify nuclear receptor binding factor 2 (NRBF2) as a regulator of this complex, and show that loss of NRBF2 impairs autophagy, enhances cell vulnerability to endoplasmic reticulum stress and promotes necrosis in the liver.

Jiahong Lu
Liqiang He
Zhenyu Yue
Research22 May 2014
Nature Communications

Volume: 5, P: 1-15
Publisher Correction: Population genomics of post-glacial western Eurasia

Morten E. Allentoft
Martin Sikora
Eske Willerslev
Amendments and CorrectionsOpen Access18 Jan 2024
Nature

Volume: 626, P: E3
A high-throughput pipeline for validation of antibodies

This paper describes a platform for carrying out antibody-based capture and mass spectrometry in parallel, and tests the feasibility of this platform for high-throughput validation of antibodies.

Krzysztof Sikorski
Adi Mehta
Fridtjof Lund-Johansen
Research30 Oct 2018
Nature Methods

Volume: 15, P: 909-912
Should we ignore western blots when selecting antibodies for other applications?

Fridtjof Lund-Johansen
Michael D Browning
Correspondence28 Feb 2017
Nature Methods

Volume: 14, P: 215
Author Correction: Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

Hanane Laklai
Yekaterina A. Miroshnikova
Valerie M. Weaver
Amendments and Corrections28 Nov 2023
Nature Medicine

Volume: 30, P: 908
A consensus protocol for functional connectivity analysis in the rat brain

The authors pooled resources to identify best practices and develop a new standardized protocol for estimating functional connectivity in rats with magnetic resonance imaging.

Joanes Grandjean
Gabriel Desrosiers-Gregoire
Andreas Hess
Research27 Mar 2023
Nature Neuroscience

Volume: 26, P: 673-681
Non-tuberculous mycobacteria and the rise of Mycobacterium abscessus

Non-tuberculous mycobacteria, such as Mycobacterium abscessus, are an increasing global health burden, in part due their extensive drug resistance. In this Review, Johansen, Herrmann and Kremer discuss the infection process, host interactions, mechanisms of drug resistance and drug development.

Matt D. Johansen
Jean-Louis Herrmann
Laurent Kremer
Reviews21 Feb 2020
Nature Reviews Microbiology

Volume: 18, P: 392-407
An adjuvanted chimeric spike antigen boosts lung-resident memory T-cells and induces pan-sarbecovirus protective immunity

Claudio Counoupas
Elizabeth Chan
James A. Triccas
ResearchOpen Access08 May 2025
npj Vaccines

Volume: 10, P: 1-11
Improved metagenome binning and assembly using deep variational autoencoders

Metagenomics data are resolved into their constituent genomes using a new deep learning method.

Jakob Nybo Nissen
Joachim Johansen
Simon Rasmussen
Research04 Jan 2021
Nature Biotechnology

Volume: 39, P: 555-560
Associations between glucocorticoid use and major adverse cardiovascular events in patients with prostate cancer receiving antiandrogen: a retrospective cohort study

Jeffrey Shi Kai Chan
Yan Hiu Athena Lee
Chi Fai Ng
ResearchOpen Access10 Sept 2024
Prostate Cancer and Prostatic Diseases

Volume: 28, P: 516-518
178 ACTIVATION OF THE KALLIKREIN-KININ SYSTEM IN RDS

O D Saugstad
L Buø
A O Aasen
Research01 Dec 1991
Pediatric Research

Volume: 30, P: 657
Suppression of c-Fos gene transcription with malignant transformation of human bronchial epithelial cells

Ho-Young Lee
Jaideep Chaudhary
Jonathan M Kurie
Research16 Jun 1998
Oncogene

Volume: 16, P: 3039-3046
Initiation of the western branch of the East African Rift coeval with the eastern branch

Rifting of the eastern part of the East African Rift System was thought to have begun several million years before its western counterpart. Reconstructions of drainage development, combined with dating of rift-related volcanic activity, suggest that rifting in the western branch may instead have begun at the same time as in the eastern branch.

E. M. Roberts
N. J. Stevens
S. Hemming
Research25 Mar 2012
Nature Geoscience

Volume: 5, P: 289-294
1013 CHEMOPROPHYLAXIS FOR CONTACTS OF CHILDREN WITH INVASIVE HAEMOPHILUS INFLUENZAE TYPE B (HIB) DISEASE

M Glode
R Daum
James K Todd
Research01 Apr 1981
Pediatric Research

Volume: 15, P: 611
The monolayer and organ culture of human colorectal carcinomata and the associated "normal" colonic mucosa and their production of carcinoembryonic antigens

J Breborowicz
G C Easty
A M Neville
Research01 May 1975
British Journal of Cancer

Volume: 31, P: 559-569
Publisher Correction: Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon

Tristram A. J. Ryan
Alexander Hooftman
Luke A. J. O’Neill
Amendments and CorrectionsOpen Access20 Jul 2023
Nature Communications

Volume: 14, P: 1
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors

Beatrice Melin, Richard Houlston, Melissa Bondy and colleagues report results of a large-scale genome-wide association study of glioma. They identify five new risk loci for glioblastoma and eight new risk loci for non-glioblastoma tumors, highlighting distinct genetic etiologies for these two glioma subtypes.

Beatrice S Melin
Jill S Barnholtz-Sloan
Melissa L Bondy
Research27 Mar 2017
Nature Genetics

Volume: 49, P: 789-794
H4K20me0 recognition by BRCA1–BARD1 directs homologous recombination to sister chromatids

Nakamura et al. show that DNA repair pathway choice and initiation of homologous recombination is guided by the recruitment of BRCA1 to post-replicative chromatin by BARD1 recognition of histone H4 tails unmethylated on lysine 20.

Kyosuke Nakamura
Giulia Saredi
Anja Groth
Research25 Feb 2019
Nature Cell Biology

Volume: 21, P: 311-318
SIRT1 is downregulated by autophagy in senescence and ageing

Xu et al. report that nuclear SIRT1 is recognized as an autophagy substrate during senescence and also observe ageing of the immune system.

Caiyue Xu
Lu Wang
Shelley L. Berger
Research28 Sept 2020
Nature Cell Biology

Volume: 22, P: 1170-1179
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

Christopher Amos and colleagues perform genome-wide association analysis for lung cancer using cohorts genotyped on the OncoArray and combing these with existing data. They identify 18 loci, 10 of which are new, finding heterogeneity across the different lung cancer subtypes, and explore candidate genes through eQTL analysis in lung tissue.

James D McKay
Rayjean J Hung
Christopher I Amos
Research12 Jun 2017
Nature Genetics

Volume: 49, P: 1126-1132
SignalP 6.0 predicts all five types of signal peptides using protein language models

A new version of SignalP predicts all types of signal peptides.

Felix Teufel
José Juan Almagro Armenteros
Henrik Nielsen
ResearchOpen Access03 Jan 2022
Nature Biotechnology

Volume: 40, P: 1023-1025
Molecular mechanisms and potential functions of histone demethylases

Histone demethylases are important for both chromatin structure and transcription. The insights being gained into their regulation and target specificity have important implications for both normal development and disease.

Susanne Marije Kooistra
Kristian Helin
Reviews04 Apr 2012
Nature Reviews Molecular Cell Biology

Volume: 13, P: 297-311
Genome-wide cell-free DNA fragmentation in patients with cancer

Analyses of fragmentation patterns of cell-free DNA in the blood of patients with cancer and healthy individuals using a machine learning algorithm provide a proof-of principle approach for the early detection and screening of human cancer.

Stephen Cristiano
Alessandro Leal
Victor E. Velculescu
Research29 May 2019
Nature

Volume: 570, P: 385-389
Radiation-induced micronuclei in human fibroblasts in relation to clonogenic radiosensitivity

MC O'Driscoll
D Scott
CML West
Research01 Dec 1998
British Journal of Cancer

Volume: 78, P: 1559-1563

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