Nature Search

Genomic and evolutionary classification of lung cancer in never smokers

Whole-genome sequencing of lung cancer in never smokers identifies different copy number subtypes and shows a lack of tobacco smoking signatures, even in cases exposed to secondhand smoke.

Tongwu Zhang
Philippe Joubert
Maria Teresa Landi
Research06 Sept 2021
Nature Genetics

Volume: 53, P: 1348-1359
Mechanism and function of synaptotagmin-mediated membrane apposition

Synaptotagmin-1 aggregates membranes in response to Ca²⁺. Using a variety of approaches, it was discovered that synaptotagmin-mediated membrane aggregation occurs through trans interactions between synaptotagmin molecules bound to different membranes. Synaptotagmin-regulated, SNARE-catalyzed fusion further requires synaptotagmin to drive the assembly of nonfusogenic syntaxin and SNAP25 into fusion-competent t-SNARE heterodimers.

Enfu Hui
Jon D Gaffaney
Edwin R Chapman
Research05 Jun 2011
Nature Structural & Molecular Biology

Volume: 18, P: 813-821
Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study

Post-acute sequelae of SARS-CoV-2 (PASC) is still not well understood. Here the authors provide patient reported outcomes from 590 hospitalized COVID-19 patients and show association of PASC with higher respiratory SARS-CoV-2 load and circulating antibody titers, and in some an elevation in circulating fibroblast growth factor 21.

Al Ozonoff
Naresh Doni Jayavelu
Nadine Rouphael
ResearchOpen Access03 Jan 2024
Nature Communications

Volume: 15, P: 1-17
Biallelic NAA60 variants with impaired N-terminal acetylation capacity cause autosomal recessive primary familial brain calcifications

Most individuals with primary familial brain calcification (PFBC) remain genetically unsolved. Here the authors show that NAA60 biallelic variants cause PFBC, likely via reduced N-terminal acetylation and SLC20A2 levels with impaired phosphate uptake.

Viorica Chelban
Henriette Aksnes
Henry Houlden
ResearchOpen Access13 Mar 2024
Nature Communications

Volume: 15, P: 1-20
Explanation at the opioid receptor level for differing toxicity of morphine and morphine 6-glucuronide

D Hucks
PI Thompson
ML Slevin
Research01 Jan 1992
British Journal of Cancer

Volume: 65, P: 122-126
Infant leukaemia after in utero exposure to radiation from Chernobyl

E. Petridou
D. Trichopoulos
F. Tzortzatou
Research25 Jul 1996
Nature

Volume: 382, P: 352-353
Direct determination of oligomeric organization of integral membrane proteins and lipids from intact customizable bilayer

Editor summary: A native-mass-spectrometry-based approach analyzes integral membrane protein–lipid complexes directly from near-physiological membrane conditions, providing information about protein oligomeric states, lipid identities, and membrane properties.

Aniruddha Panda
Fabian Giska
Kallol Gupta
Research27 Apr 2023
Nature Methods

Volume: 20, P: 891-897
Two high-risk susceptibility loci at 6p25.3 and 14q32.13 for Waldenström macroglobulinemia

Waldenström macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL) is a non-Hodgkin-type B cell lymphoma. Here, the authors identify two risk loci for WM/LPL in a two-stage GWAS involving a family-oversampling approach and provide evidence for a functional role of the non-coding SNP rs116446171.

Mary L. McMaster
Sonja I. Berndt
Neil E. Caporaso
ResearchOpen Access10 Oct 2018
Nature Communications

Volume: 9, P: 1-12
Evaluation of the extended efficacy of the Dengvaxia vaccine against symptomatic and subclinical dengue infection

Multiyear analysis of antibody responses in recipients of the dengue vaccine Dengvaxia in the Philippines supports their utility as a predictor of protection against disease, and reveals that Dengvaxia efficacy declines 3 years after complete vaccination.

Henrik Salje
Maria Theresa Alera
Alan L. Rothman
Research24 Jun 2021
Nature Medicine

Volume: 27, P: 1395-1400
Proton NMR Observation of Phenylalanine and an Aromatic Metabolite in the Rabbit Brain in Vivo

M J Avison
N Herschkowitz
J W Prichard
Research01 Jun 1990
Pediatric Research

Volume: 27, P: 566-570
Detectable clonal mosaicism and its relationship to aging and cancer

Luis Pérez-Jurado, Stephen Chanock and colleagues detect clonal chromosomal abnormalities in peripheral blood or buccal samples from individuals in the general population. They show that the frequency of such events increases with age and is associated with elevated risk of developing subsequent hematological cancers.

Kevin B Jacobs
Meredith Yeager
Stephen J Chanock
Research06 May 2012
Nature Genetics

Volume: 44, P: 651-658
Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility

Ewing sarcoma (EWS) is a rare pediatric bone cancer typically involving the EWSR1-FLI1 fusion. Here the authors perform a genome-wide association study and report three new EWS risk loci that reside near GGAA repeat sequences, and identify candidate genes (RREB1 and KIZ) from eQTL analysis.

Mitchell J. Machiela
Thomas G. P. Grünewald
Olivier Delattre
ResearchOpen Access09 Aug 2018
Nature Communications

Volume: 9, P: 1-8
Temporal variation selects for diet–microbe co-metabolic traits in the gut of Gorilla spp

Andres Gomez
Jessica M Rothman
Steven R Leigh
Research28 Aug 2015
The ISME Journal

Volume: 10, P: 514-526
Correction: Pulsed high-energy γ-rays from the radio pulsar PSR1706–44

D. J. Thompson
Z. Arzoumanian
J. H. Taylor
Amendments and Corrections09 Sept 1993
Nature

Volume: 365, P: 188
Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects

N. D. Volkow
G.-J. Wang
N. Pappas
Research24 Apr 1997
Nature

Volume: 386, P: 830-833
Nanoscale subcellular architecture revealed by multicolor three-dimensional salvaged fluorescence imaging

4Pi single-molecule switching microscopy combined with ‘salvaged fluorescence’ enables improved ratiometric imaging that bypasses chromatic aberrations and allows for multicolor whole-cell imaging with sub-10-nm localization precision.

Yongdeng Zhang
Lena K. Schroeder
Joerg Bewersdorf
Research06 Jan 2020
Nature Methods

Volume: 17, P: 225-231
Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32

Christine Skibola and colleagues identify variants at 6p21.32 associated with risk of follicular lymphoma, providing further support that variation in the MHC region influences risk of this disease. They also replicate previously reported risk variants for chronic lymphocytic leukemia.

Lucia Conde
Eran Halperin
Christine F Skibola
Research18 Jul 2010
Nature Genetics

Volume: 42, P: 661-664
Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia

Chronic lymphocytic leukaemia has a hereditary component, much of which remains to be identified. Here, the authors perform a genome-wide association study and find new risk loci for the disease, which are associated with genes involved in immune function.

Philip J. Law
Sonja I. Berndt
Susan Slager
ResearchOpen Access06 Feb 2017
Nature Communications

Volume: 8, P: 1-12
Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer

A cross-ancestry genome-wide association meta-analysis of lung cancer including 61,047 cases and 947,237 controls identifies five new cross-ancestry susceptibility loci and highlights ancestry-specific effects of common and rare variants on lung cancer risk.

Jinyoung Byun
Younghun Han
Christopher I. Amos
Research01 Aug 2022
Nature Genetics

Volume: 54, P: 1167-1177
Relationship between subjective effects of cocaine and dopamine transporter occupancy

N. D. Volkow
G.-J. Wang
C. E. Shea
Research24 Apr 1997
Nature

Volume: 386, P: 827-830
Exuberant fibroblast activity compromises lung function via ADAMTS4

Viral infection of the respiratory system induces exuberant fibroblast activity, resulting in extensive remodelling of the extracellular matrix and cytokine release, which promote immune cell infiltration of the affected area at the expense of respiratory function.

David F. Boyd
E. Kaitlynn Allen
Paul G. Thomas
Research28 Oct 2020
Nature

Volume: 587, P: 466-471
Destabilization of the complete protein secondary structure on binding to the chaperone GroEL

Ralph Zahn
Claus Spitzfaden
Andreas Plückthun
Research17 Mar 1994
Nature

Volume: 368, P: 261-265
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

Genetic variants associated with susceptibility to pancreatic cancer have been identified using genome wide association studies (GWAS). Here, the authors combine data from over 9000 patients and perform a meta-analysis to identify five novel loci linked to pancreatic cancer.

Alison P. Klein
Brian M. Wolpin
Laufey T. Amundadottir
ResearchOpen Access08 Feb 2018
Nature Communications

Volume: 9, P: 1-11
Brain and body energy metabolism and potential for treatment of psychiatric disorders

This Perspective highlights the important role of energy metabolism in psychiatric disorders and sets the groundwork for future studies in the emerging field of metabolic psychiatry.

Ana C. Andreazza
L. Felipe Barros
Corey Weistuch
Reviews25 Jun 2025
Nature Mental Health

Volume: 3, P: 763-771
1-(m-Chlorophenyl)piperazine (mCPP) Dissociates In Vivo Serotonin Release from Long-Term Serotonin Depletion in Rat Brain

Michael H Baumann
Mario A Ayestas
Richard B Rothman
Research01 May 2001
Neuropsychopharmacology

Volume: 24, P: 492-501
Selected peptides targeted to the NMDA receptor channel protect neurons from excitotoxic death

Antonio V. Ferrer-Montiel
Jaime M. Merino
Mauricio Montal
Research01 Mar 1998
Nature Biotechnology

Volume: 16, P: 286-291
Impact of circulating SARS-CoV-2 variants on mRNA vaccine-induced immunity

Immune analyses against circulating SARS-CoV-2 variants show that mRNA vaccination induces robust neutralizing antibodies and boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection.

Carolina Lucas
Chantal B. F. Vogels
Akiko Iwasaki
Research11 Oct 2021
Nature

Volume: 600, P: 523-529
The ontogeny of the neural crest in avian embryo chimaeras

Nicole M. Le Douarin
Reviews14 Aug 1980
Nature

Volume: 286, P: 663-669
The inheritance of quantitative fitness traits in guppies, Poecilia reticulata (Pisces: Poeciliidae). II. tests for inbreeding effects

James A Farr
Karin Peters
Research01 Apr 1984
Heredity

Volume: 52, P: 285-296
Age-Related Alterations of Immunoreactive Pancreatic Cationic Trypsinogen in Sera from Cystic Fibrosis Patients with and without Pancreatic Insufficiency

P R Durie
G G Forstner
M L Corey
Research01 Mar 1986
Pediatric Research

Volume: 20, P: 209-213
Smoking and Epstein–Barr virus infection in multiple sclerosis development

Anna Karin Hedström
Jesse Huang
Lars Alfredsson
ResearchOpen Access03 Jul 2020
Scientific Reports

Volume: 10, P: 1-7
ICE/CED3-like Proteases as Therapeutic Targets for the Control of Inappropriate Apoptosis

Donald W. Nicholson
Reviews01 Mar 1996
Nature Biotechnology

Volume: 14, P: 297-301
A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is characterised by progressive pulmonary vascular remodelling. Here, Arnold et al. develop a therapeutic antibody targeting osteoprotegerin and find it attenuates pulmonary vascular remodelling in multiple rodent models of PAH, alone or in combination with standard of care vasodilator therapy.

Nadine D. Arnold
Josephine A. Pickworth
Allan Lawrie
ResearchOpen Access15 Nov 2019
Nature Communications

Volume: 10, P: 1-18
AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders

Genetic variants in ionotropic glutamate receptors have been implicated in neurodevelopmental disorders. Here, the authors report heterozygous de novo mutations in the GRIA2 gene in 28 individuals with intellectual disability and neurodevelopmental abnormalities associated with reduced Ca²⁺ transport and AMPAR currents.”

Vincenzo Salpietro
Christine L. Dixon
Henry Houlden
ResearchOpen Access12 Jul 2019
Nature Communications

Volume: 10, P: 1-16
Answers that lie in the soil

Peter D. Moore
News & Views28 Dec 1989
Nature

Volume: 342, P: 858
On the use of population-based registries in the clinical validation of genetic tests for disease susceptibility

Quanhe Yang
Muin J Khoury
W Dana Flanders
Research01 May 2000
Genetics in Medicine

Volume: 2, P: 186-192
Multiple primary breast and thyroid cancer

E Ron
R Curtis
J T Flannery
Research01 Jan 1984
British Journal of Cancer

Volume: 49, P: 87-92
Association of germline variants in the APOBEC3 region with cancer risk and enrichment with APOBEC-signature mutations in tumors

Ludmila Prokunina-Olsson and colleagues report a fine-mapping and association analysis of germline variants in the APOBEC3 region associated with cancer risk. They identify two variants with differential effects in bladder and breast cancer, and their in vitro results suggest that environmental exposures may induce tissue-specific APOBEC mutagenesis and contribute to oncogenesis in carriers of APOBEC3 risk variants.

Candace D Middlebrooks
A Rouf Banday
Ludmila Prokunina-Olsson
Research19 Sept 2016
Nature Genetics

Volume: 48, P: 1330-1338
Interleukin-1 polymorphisms associated with increased risk of gastric cancer

Emad M. El-Omar
Mary Carrington
Charles S. Rabkin
Research23 Mar 2000
Nature

Volume: 404, P: 398-402
Science and values

D.M. TRUBSHAW
Correspondence01 Jan 1981
Nature

Volume: 289, P: 107
Successful pregnancy in acute monocytic leukaemia

R Gokal
J Durrant
M J Bennett
Research01 Sept 1976
British Journal of Cancer

Volume: 34, P: 299-302
Hypersensitivity to seizures in β-amyloid precursor protein deficient mice

Joachim P Steinbach
Ulrike Müller
Adriano Aguzzi
Research22 Oct 1998
Cell Death & Differentiation

Volume: 5, P: 858-866
Carl von Linné's Bedeutung als Naturforscher und Arzt

B. D. J.
Books & Arts30 Sept 1909
Nature

Volume: 81, P: 391
The mammalian Golgi — complex debates

Brad J. Marsh
Kathryn E. Howell
Reviews01 Oct 2002
Nature Reviews Molecular Cell Biology

Volume: 3, P: 789-795
HHEX gene polymorphisms are associated with type 2 diabetes in the Dutch Breda cohort

Jana V van Vliet-Ostaptchouk
N Charlotte Onland-Moret
Cisca Wijmenga
Research30 Jan 2008
European Journal of Human Genetics

Volume: 16, P: 652-656
Developmental Maturation of Calcium Transport by Rat Brush Border Membrane Vesicles

Fayez K Ghishan
Noushin Arab
Research01 Aug 1987
Pediatric Research

Volume: 22, P: 173-176
Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood

Idiopathic pulmonary arterial hypertension is a rare and fatal disease with a heterogeneous treatment response. Here the authors show that unsupervised machine learning of whole blood transcriptomes from 359 patients with idiopathic pulmonary arterial hypertension identifies 3 subgroups (endophenotypes) that improve risk stratification and provide new molecular insights.

Sokratis Kariotis
Emmanuel Jammeh
Richard C. Trembath
ResearchOpen Access07 Dec 2021
Nature Communications

Volume: 12, P: 1-14
The slow process of succession

Peter D. Moore
News & Views04 Dec 1980
Nature

Volume: 288, P: 436
Serum cholesterol and primary brain tumours: A case-control study

Z H Abramson
J D Kark
Research01 Jul 1985
British Journal of Cancer

Volume: 52, P: 93-98
Residential environmental exposures and other characteristics associated with detectable PAH-DNA adducts in peripheral mononuclear cells in a population-based sample of adult females

Sumitra Shantakumar
Marilie D Gammon
Regina M Santella
Research27 Apr 2005
Journal of Exposure Science & Environmental Epidemiology

Volume: 15, P: 482-490

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