CD8+ T cell responses have been associated with control of HIV replication, but the role of CD4+ T cells in protecting against this virus is unclear. In an analysis of HLA class II–restricted CD4+ T cell responses in HIV-infected individuals, Hendrik Streeck and his colleagues now report that certain HLA-DRB1 variants are associated with low viremia and can present a wide breadth of peptides, suggesting that CD4+ T cell responses in infected individuals may help control HIV.
- Srinika Ranasinghe
- Sam Cutler
- Hendrik Streeck