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Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Tracers are fluorescent protein ligands required for various displacement assays. Here, the authors announce a curated database named tracerDB, which will make essential tracer data, contributed by the worldwide research community, easily available and searchable.

In a prospective study involving 579,583 women in multiple sites across the USA, a multistage AI-driven workflow for digital breast tomosynthesis mammograms assisted radiologists in identifying 21.6% more cancers with respect to historical data, showing no significant variation across socio-demographic and breast density subgroups.

Here authors show loss of AKAP11, a strong genetic risk factor for bipolar disorder and schizophrenia, disrupts PKA proteostasis and signaling, leading to widespread transcriptomic alterations across the brain, particularly in striatal neurons, as well as altered behavior.

Roles of of viruses in ocean subsurface oxygen maxima are unclear. Here, the authors analyse Bermuda Atlantic Time Series data to show that viruses may drive SOM in stratified oceans by boosting nutrient recycling and phytoplankton productivity linking virus activity to oxygen buildup and a stronger microbial loop.

Crystal growth is visualized inside non-transparent liquid metals, while preserving their original state, using X-ray micro-computed tomography to reveal how liquid metal solvent composition and cooling conditions influence crystal formation.

Targeting a non-natural micropeptide ‘killswitch’ to several biomolecular condensates altered condensate compositions and revealed condensate functions in human cells

During plant cultivation, denitrification process can release greenhouse gas nitrous oxide (N₂O) to atmosphere. Here, the authors develop a soybean–bradyrhizobial symbiosis system with enhanced capacity to reduce N₂O emissions using the incompatibility between two soybean R genes and their effector present in bradyrhizobia.

The Zika viral protease NS2B-NS3 is a crucial target for antiviral drug development due to its role in processing viral polyproteins. Here, the authors utilize crystallographic fragment screening and deep mutational scanning to identify binding sites for resistance-resilient inhibitors.

A transition from carbon sink to source for the aboveground woody biomass of moist tropical Australian forests has occurred, driven by increasingly extreme climate anomalies.

Quantum simulations of the phase diagram of quantum chromodynamics faces hard challenges, such as having to prepare mixed states and enforcing the non-Abelian gauge symmetry constraints. Here, the authors show how to solve the two above problems in a trapped-ion device using motional ancillae and charge-singlet measurements.

Parallel operation of two exchange-only qubits consisting of six quantum dots arranged linearly is shown to be achievable and maintains qubit control quality compared with sequential operation, with potential for use in scaled quantum computing.

Eosinophils exist as a functionally heterogeneous population. Whether the heterogeneity is driven by cell-intrinsic or extrinsic factors is underexplored. Here, by leveraging single-cell transcriptomic data and epigenomic analysis, the authors propose that local environmental cues define the gene expression program of murine esophageal eosinophils and identify AP-1 family members, including ATF3, as key regulators of gene expression.

The Omicron variant evades vaccine-induced neutralization but also fails to form syncytia, shows reduced replication in human lung cells and preferentially uses a TMPRSS2-independent cell entry pathway, which may contribute to enhanced replication in cells of the upper airway. Altered fusion and cell entry characteristics are linked to distinct regions of the Omicron spike protein.

Experimental measurements of high-order out-of-time-order correlators on a superconducting quantum processor show that these correlators remain highly sensitive to the quantum many-body dynamics in quantum computers at long timescales.

The standard band structure picture cannot be applied to amorphous materials as they lack crystal symmetry. Now a first-principles approach that captures the possibility of band-like electron transport in amorphous solids is presented, with In₂O₃ as an example.

Engineered DNA recombinases efficiently and specifically insert genetic cargos without the use of landing pads.

Comprehensive large-scale studies of multi-national populations identified microbiome species consistently associated with favourable and unfavourable health markers, informing future studies of the human gut microbiome and its association with diet and cardiometabolic conditions.

Dual cyclin A/B RxL inhibitors selectively kill small cell lung cancer cells and other cancer cells with high E2F activity.

Using well-calibrated statistical methods the authors jointly analyze Undiagnosed Diseases Network genomes, identifying known and novel disease genes. Software is publicly available to support future cross-cohort rare disease discovery efforts.

The authors identify changes in insect distribution across Great Britain since 1990. The changes appear connected to insect traits, notably with species with multiple generations per year benefiting from increasing temperatures, particularly in the North.

The placenta plays vital roles in supporting fetal development. Here, Richards et al. develop a high-throughput bioprinted trophoblast organoid model to recapitulate the microenvironment of the early placenta, enabling investigation of placenta development and evaluation of therapeutics for placenta dysfunction disorders.

Surgical menopause occurs in premenopausal women who undergo radical cystectomy with bilateral oophorectomy to treat bladder cancer. This Review discusses the pathophysiology of surgical menopause in these patients and highlights current strategies to mitigate associated symptoms and long-term health risks.

Degree distributions are often used as informative descriptions of complex networks, however previous studies mainly focused on characterizing the tail of the distribution. The authors propose an evolutionary model that integrates the weight and degree of a node, which allows to better capture degree and degree ratio distributions of real networks and replicate their evolution processes.

Stability and flexibility are important, if antagonistic, features of memory. Here the authors show that a class of inhibitory neurons regulate plasticity and therefore the stability of memory representations in novel contexts requiring flexibility.

FOS has been linked to bone tumour pathogenesis, and viral homologue v-fos causes osteosarcoma in mice. Here, the authors report rearrangement of FOS and its paralogue FOSB in osteoblastoma and osteoid osteoma, revealing human bone tumours that are defined by mutations of FOS and FOSB.

The pathogen Streptococcus pneumoniae can adapt to diverse microenvironments in the human body. Here, De Bakker et al. study these adaptation responses, showing unusual sugar utilization and identifying FasR as a regulator of membrane composition and heat stress resistance.

The genomic and immune landscape of pre-invasive lung adenocarcinoma is poorly understood. Here, the authors perform exome and transcriptome sequencing on precursor legions and invasive lung adenocarcinomas, identifying recurrently mutated genes in pre/minimally invasive cases, and arm level alteration events linked to immune infiltration.

Riparian vegetation reduced gulf turbidity up to 800 meters offshore, overlapping coral reefs and seagrasses, while pasture and gravel roads increased turbidity, according to a scalable framework using remote sensing and causal inference methods.

The research explores how ultrasound-based human-machine interfaces generalize across a wide variety of situations and participants. Robustness was achieved, with new users able to control virtual hands without the need for calibration.

An optimal model-experiment integration for testing many complex hypotheses is still lacking. Here authors introduce improv, a modular software platform enabling real-time adaptive neuroscience experiments, orchestrating parallel data collection, modeling, and experimental control. Authors demonstrate various use cases, including online neural analysis and closed-loop optogenetics in zebrafish.

Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing epithelial–stromal remodelling and suppression of luminal progenitors.

KDM4C regulates cathepsin L-mediated histone H3 N-terminal tail clipping through grainyhead-like 2 (GRHL2) methylation in breast cancer. This link between the cellular redox state and chromatin remodeling might represent a therapeutic target in KDM4C-amplified tumors.

Efficient, large-scale genomic analysis is facilitated on the cloud by a computational tool with error-diagnosing and self-healing capabilities.

PARP inhibitors, either alone or in combination with bevacizumab, have regulatory approval as maintenance therapy following response to first-line platinum-based chemotherapy. Here this group reports SOLACE2 trial investigating whether combining olaparib with low dose cyclophosphamide treatment improves progression-free survival, comparing to olaparib monotherapy alone, in platinum-sensitive recurrent ovarian cancer.

Excised signal circles are circular DNA by-products of V(D)J recombination that form a complex with the V(D)J recombinase, and when increased in abundance, result in increased mutagenesis, causing adverse outcomes in cancer.

As presented at the ESMO Congress 2025: Results of the phase 2/3 AGITG DYNAMIC-III trial show that de-escalated chemotherapy based on ctDNA-negative status in patients with stage III colon cancer did not meet non-inferiority for 3-year recurrence-free survival when compared to standard of care, although it enables better informed treatment decisions.

cSplotch compares spatial transcriptomics data across ages and regions of mouse colon tissue.

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

Rhizosphere viruses mediate arsenic (As) biogeochemistry by promoting lysogeny in As-oxidizing microbes. Metagenomics, metabolic modeling, and in vitro experiments estimate rhizosphere lysogenic viruses contribute to up to 25% of microbial As oxidation.

LIG3α forms a complex with XRCC1 during single strand break and base excision repair. Here, the authors show that LIG3α displays higher affinity for nicks than XRCC1 and binds with its N-terminal ZnF domain more avidly to an undamaged nucleosome.

Methods for developing machine learning models in medical imaging across multi-centre collaborations face important challenges, including technical burdens and privacy issues. Here, the authors introduce CATegorical and PHenotypic Image SyntHetic learnING - CATphishing - as an alternative to Federated Learning to generate synthetic multi-contrast 3D MRI data for downstream tasks.

Using multi-omic analyses, the authors reveal how aging, sex, and trisomy 21 shape human biology across the lifespan, showing that age- and sex-specific changes peak during puberty and adulthood, while trisomy 21 exerts differential effects over time.

α/β-hydrolase domain-containing protein 11 (ABHD11) is a mitochondrial hydrolase, and its expression in CD4 + T-cells has been linked to remission status in rheumatoid arthritis. Here the authors report that pharmacological inhibition of ABHD11 modulates T-cell effector function via increased 24,25-epoxycholesterol biosynthesis and subsequent liver X receptor activation.