Nature Search

In situ structure of a bacterial flagellar motor at subnanometre resolution reveals adaptations for increased torque

In situ cryoEM and modelling of the Campylobacter jejuni flagellar motor characterize the periplasmic scaffold and the structural basis for increased torque generation.

Tina Drobnič
Eli J. Cohen
Morgan Beeby
ResearchOpen Access01 Jul 2025
Nature Microbiology

Volume: 10, P: 1723-1740
Immune checkpoint inhibitors plus debulking surgery for patients with metastatic renal cell carcinoma: clinical outcomes and immunological correlates of a prospective pilot trial

Clinical evidence suggests that debulking surgery in patients with metastatic disease could enhance response to immune checkpoint therapy. Here the authors report the results of a clinical trial of immune checkpoint inhibitors plus debulking surgery in patients with metastatic renal cell carcinoma.

Sangeeta Goswami
Jianjun Gao
Padmanee Sharma
ResearchOpen Access21 Feb 2025
Nature Communications

Volume: 16, P: 1-13
BWC0977, a broad-spectrum antibacterial clinical candidate to treat multidrug resistant infections

In this work, the authors probe the efficacy of BWC0977, a bacterial topoisomerase inhibitor, in pre-clinical animal models, also demonstrating that BWC0977 is safe and well tolerated in healthy human volunteers, in a phase 1 trial.

Shahul Hameed P
Harish Kotakonda
Balasubramanian V
ResearchOpen Access18 Sept 2024
Nature Communications

Volume: 15, P: 1-20
Failure of acids to eliminate aziridinyl residues in chemosterilised mosquitoes

J. A. SEAWRIGHT
D. A. CARLSON
K. D. KONYHA
Research04 May 1978
Nature

Volume: 273, P: 76
Artificial Stimulation of Rain at Kongwa

D. A. DAVIES
Research14 Jun 1952
Nature

Volume: 169, P: 1001-1002
Seasonal prediction of Indian summer monsoon extreme rainfall frequency

Devabrat Sharma
Santu Das
B. N. Goswami
ResearchOpen Access13 Apr 2025
npj Climate and Atmospheric Science

Volume: 8, P: 1-11
Attention-based hybrid deep learning model with CSFOA optimization and G-TverskyUNet3+ for Arabic sign language recognition

Ahmed A. Mohamed
Abdullah Al-Saleh
Ghanshyam Tejani
ResearchOpen Access26 Jun 2025
Scientific Reports

Volume: 15, P: 1-33
Lithocholic acid facilitates release of angiocrine factors by liver sinusoidal endothelial cells during liver regeneration

Impreet Kaur
Aarti Sharma
Savneet Kaur
ResearchOpen Access30 Sept 2025
npj Gut and Liver

Volume: 2, P: 1-13
Advanced deep learning approach for the fault severity classification of rolling-element bearings

Vivek Parmar
Shirshendu Layek
Arpit Kumar Sharma
ResearchOpen Access02 Oct 2025
Scientific Reports

Volume: 15, P: 1-20
CHASHNIt for enhancing skin disease classification using GAN augmented hybrid model with LIME and SHAP based XAI heatmaps

Saksham Anand
Abhiram Sharma
R. Elakkiya
ResearchOpen Access24 Aug 2025
Scientific Reports

Volume: 15, P: 1-20
Unveiling the attitudinal factors: an integration of TPB and SCT in understanding investor intention towards equity investments

Anurag Singh
Utkarsh Goel
Amar Johri
ResearchOpen Access29 Sept 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-14
Structure-function relationship of ASH1L and histone H3K36 and H3K4 methylation

Mutations of the histone H3K36-specific methyltransferase ASH1L have been linked to several human diseases. Here, the authors report the mechanism by which three C-terminal domains in ASH1L regulate its enzymatic activity and interact with chromatin.

Kendra R. Vann
Rajal Sharma
Tatiana G. Kutateladze
ResearchOpen Access06 Mar 2025
Nature Communications

Volume: 16, P: 1-15
Measurement of the Higgs boson width and evidence of its off-shell contributions to ZZ production

The CMS Collaboration reports evidence for off-shell Higgs boson contributions in the production of Z boson pairs, and measures the width of the Higgs boson, which is inversely related to its lifetime.

A. Tumasyan
W. Adam
W. Vetens
ResearchOpen Access20 Oct 2022
Nature Physics

Volume: 18, P: 1329-1334
Observation of triple J/ψ meson production in proton-proton collisions

The CMS Collaboration reports the study of three simultaneous hard interactions between quarks and gluons in proton–proton collisions. This manifests through the concurrent production of three J/ψ mesons, which consist of a charm-quark–antiquark pair.

A. Tumasyan
W. Adam
W. Vetens
ResearchOpen Access19 Jan 2023
Nature Physics

Volume: 19, P: 338-350
A deep learning framework for automated early diagnosis and classification of skin cancer lesions in dermoscopy images

Alaa S. Al-Waisy
Shumoos Al-Fahdawi
Mohammed Nasser Al-Andoli
ResearchOpen Access25 Aug 2025
Scientific Reports

Volume: 15, P: 1-20
Research Environments and Productivity

S. P. GUPTA
K. D. SHARMA
Research01 Aug 1971
Nature

Volume: 232, P: 450-452
Krylov diagonalization of large many-body Hamiltonians on a quantum processor

The estimation of low energies of many-body systems is a cornerstone of the computational quantum sciences. This paper demonstrates on a superconducting quantum processor that the Krylov quantum diagonalization algorithm is poised to complement its classical counterparts at the foundation of computational methods for quantum systems.

Nobuyuki Yoshioka
Mirko Amico
Antonio Mezzacapo
ResearchOpen Access24 Jun 2025
Nature Communications

Volume: 16, P: 1-8
Fe-phosphates in Jezero Crater as evidence for an ancient habitable environment on Mars

The Perseverance rover has made the most definitive identification of Fe-phosphate minerals on Mars to date. High-resolution chemical and textural PIXL analyses suggest they originally formed after vivianite in a potentially habitable environment.

T. V. Kizovski
M. E. Schmidt
A. C. Allwood
ResearchOpen Access14 Jul 2025
Nature Communications

Volume: 16, P: 1-12
Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts

Rao and Cai et al. perform a detailed metabolic comparison between primary tumours from patients and their matching xenografts, which identify conserved as well as divergent metabolic patterns.

Aparna D. Rao
Ling Cai
Jennifer G. Gill
ResearchOpen Access29 Jul 2025
Nature Metabolism

Volume: 7, P: 1703-1713
A pathogenic role for IL-10 signalling in capillary stalling and cognitive impairment in type 1 diabetes

Interleukin-10 promotes the formation of microcirculatory defects in the brain associated with cognitive impairment in a mouse model of type 1 diabetes.

Sorabh Sharma
Manjinder Cheema
Craig E. Brown
ResearchOpen Access04 Nov 2024
Nature Metabolism

Volume: 6, P: 2082-2099
Global evolution of inflammatory bowel disease across epidemiologic stages

An analysis of data from 522 population-based studies encompassing 82 global regions and spanning more than a century (1920–2024) shows spatiotemporal transitions across epidemiologic stages 1 to 3 of inflammatory bowel disease, and models stage 4 progression.

Lindsay Hracs
Joseph W. Windsor
Gilaad G. Kaplan
ResearchOpen Access30 Apr 2025
Nature

Volume: 642, P: 458-466
IDH status dictates oHSV mediated metabolic reprogramming affecting anti-tumor immunity

The role of glioma cellular metabolism in response to oncolytic herpes virus (oHSV) therapy remains to be studied. Here the authors report that oHSV induces metabolic reprogramming in IDH wildtype glioma cells, leading to ferroptosis and anti-tumor immune response. Pharmacological blockade of mutant IDH enhances glioma cell sensitivity to oHSV therapy.

Upasana Sahu
Matthew P. Mullarkey
Balveen Kaur
ResearchOpen Access24 Apr 2025
Nature Communications

Volume: 16, P: 1-21
Resistance to Marek's Disease in Immunologically Deficient Chickens

J. M. SHARMA
Research11 Jan 1974
Nature

Volume: 247, P: 117-118
Modeling Urotropine adsorption thermodynamic on kaolinite particles

Qingling Zhu
Zahraa Sabah Ghnim
Khursheed Muzammil
ResearchOpen Access08 Oct 2025
Scientific Reports

Volume: 15, P: 1-14
A FAN1 point mutation associated with accelerated Huntington’s disease progression alters its PCNA-mediated assembly on DNA

Patients with Huntington’s disease carrying the FAN1 R507H mutation have earlier than predicted onset of motoric symptoms. This study provides mechanistic insight into the interactions that may promote CAG repeat expansion. FAN1 R507 interacts with PCNA D232 and this interaction is impaired for FAN1 R507H, resulting in reduced FAN1 activity.

Jonas Aretz
Gayathri Jeyasankar
Brinda C. Prasad
ResearchOpen Access14 May 2025
Nature Communications

Volume: 16, P: 1-14
Impact of halide variation on the optoelectronic properties of double perovskites

Deepak Choudhary
Mandeep Kaur
Manendra
ResearchOpen Access29 Sept 2025
Scientific Reports

Volume: 15, P: 1-14
Divergent molecular pathways govern temperature-dependent wheat stem rust resistance genes

Wheat stem rust resistance gene Sr6-mediated resistance is enhanced at lower temperatures whereas Sr13 and Sr21 resistances are enhanced at higher temperatures. Here, the authors clone Sr6 and show the divergent molecular pathways governing temperature-dependent resistance among these genes.

Tim C. Hewitt
Keshav Sharma
Matthew N. Rouse
ResearchOpen Access28 May 2025
Nature Communications

Volume: 16, P: 1-13
Development and validation of a prognostic model and risk calculator for the estimation of bipolar-spectrum disorder risk in hospitalised adolescents with non-psychotic/non-bipolar mental disorders

Gonzalo Salazar de Pablo
Joaquim Radua
Christoph U. Correll
ResearchOpen Access29 Sept 2025
Molecular Psychiatry

P: 1-10
A portrait of the Higgs boson by the CMS experiment ten years after the discovery

The most up-to-date combination of results on the properties of the Higgs boson is reported, which indicate that its properties are consistent with the standard model predictions, within the precision achieved to date.

A. Tumasyan
W. Adam
A. Zhokin
ResearchOpen Access04 Jul 2022
Nature

Volume: 607, P: 60-68
Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4⁺8⁺ thymocytes

Pawel Kisielow
Horst Blüthmann
Harald von Boehmer
Research23 Jun 1988
Nature

Volume: 333, P: 742-746
Acto-myosin force organization modulates centriole separation and PLK4 recruitment to ensure centriole fidelity

Centriolar separation is thought to be crucial for centriole duplication, but the mechanism behind separation is poorly understood. Here, using micropatterning, the authors report that actomyosin forces influence the direction, distance, and time of centriole separation.

Elisa Vitiello
Philippe Moreau
Martial Balland
ResearchOpen Access03 Jan 2019
Nature Communications

Volume: 10, P: 1-12
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Imaging shapes of atomic nuclei in high-energy nuclear collisions

The collective-flow-assisted nuclear shape-imaging method images the nuclear global shape by colliding them at ultrarelativistic speeds and analysing the collective response of outgoing debris.

M. I. Abdulhamid
B. E. Aboona
M. Zyzak
ResearchOpen Access06 Nov 2024
Nature

Volume: 635, P: 67-72
Neoantigen-specific cytotoxic Tr1 CD4 T cells suppress cancer immunotherapy

Type 1 regulatory T cells (Tr1) represent a major obstacle that compromises naturally occurring and therapeutically induced tumour-specific immunity.

Hussein Sultan
Yoshiko Takeuchi
Robert D. Schreiber
ResearchOpen Access24 Jul 2024
Nature

Volume: 632, P: 182-191
Microsatellite alterations in serum DNA of head and neck cancer patients

Homaira Nawroz
Wayne Koch
David Sidransky
Research01 Sept 1996
Nature Medicine

Volume: 2, P: 1035-1037
Linkage mapping of dopa–responsive dystonia (DRD) to chromosome 14q

Torbjoern G. Nygaard
Kirk C. Wilhelmsen
Daniel E. Weeks
Research01 Dec 1993
Nature Genetics

Volume: 5, P: 386-391
Direct observation of the dead-cone effect in quantum chromodynamics

The direct measurement of the QCD dead cone in charm quark fragmentation is reported, using iterative declustering of jets tagged with a fully reconstructed charmed hadron.

S. Acharya
D. Adamova
N. Zurlo
ResearchOpen Access18 May 2022
Nature

Volume: 605, P: 440-446
Burdens of type 2 diabetes and cardiovascular disease attributable to sugar-sweetened beverages in 184 countries

Estimates from the Global Dietary Database indicated that 2.2 million new type 2 diabetes and 1.2 million new cardiovascular disease cases were attributable to sugar-sweetened beverages worldwide in 2020, with the highest burdens in sub-Saharan Africa, Latin America and the Caribbean.

Laura Lara-Castor
Meghan O’Hearn
Rubina Hakeem
ResearchOpen Access06 Jan 2025
Nature Medicine

Volume: 31, P: 552-564
A dietary commensal microbe enhances antitumor immunity by activating tumor macrophages to sequester iron

Here the authors show that a heteropolysaccharide from a commensal bacteria commonly found in the Korean food kimchi is able to bolster antitumor immune responses by instructing tumor-associated macrophages to release lipocalin-2, which sequesters iron away from tumor cells contributing to the immune response to attack these cells.

Garima Sharma
Amit Sharma
Sin-Hyeog Im
Research25 Apr 2024
Nature Immunology

Volume: 25, P: 790-801
Linkage of an important gene locus for tuberous sclerosis to a chromosome 16 marker for polycystic kidney disease

R. S. Kandt
J. L. Haines
M. A. Pericak-Vance
Research01 Sept 1992
Nature Genetics

Volume: 2, P: 37-41
Measurement of anti-³He nuclei absorption in matter and impact on their propagation in the Galaxy

Measurements of the inelastic cross section of anti-³He allow the estimation of the transparency of the Milky Way to the propagation of these light antinuclei produced in either cosmic-ray collisions or annihilation of dark-matter particles.

S. Acharya
D. Adamová
N. Zurlo
ResearchOpen Access12 Dec 2022
Nature Physics

Volume: 19, P: 61-71
Observation of quantum entanglement with top quarks at the ATLAS detector

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s = 13 TeV and an integrated luminosity of 140 fb⁻¹.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access18 Sept 2024
Nature

Volume: 633, P: 542-547
Drivers and Impacts of the Record-Breaking 2023 Wildfire Season in Canada

The record-breaking 2023 wildfire season in Canada ( ~ 15 Mha burned) was enabled by early snowmelt, drought, and extreme weather. It had profound impacts that included evacuation of >200 communities, millions exposed to hazardous smoke, and a strain on fire-fighting resources.

Piyush Jain
Quinn E. Barber
Marc-André Parisien
ResearchOpen Access20 Aug 2024
Nature Communications

Volume: 15, P: 1-14
Parallel sub class modified teaching learning based optimization

Ghanshyam G. Tejani
Sunil Kumar Sharma
Shailendra Mishra
ResearchOpen Access29 Aug 2025
Scientific Reports

Volume: 15, P: 1-38
Optimized bio-signal reconstruction and watermarking via enhanced fractional orthogonal moments

Gaber Hassan
Khalid M. Hosny
Islam S. Fathi
ResearchOpen Access19 Aug 2025
Scientific Reports

Volume: 15, P: 1-21
Myeloid-specific KDM6B inhibition sensitizes glioblastoma to PD1 blockade

Goswami and colleagues identify high expression of KDM6B in immune-suppressive myeloid cells in glioblastoma and show that its myeloid cell-specific deletion enhances inflammatory signaling and antigen presentation, thereby extending survival.

Sangeeta Goswami
Deblina Raychaudhuri
Padmanee Sharma
Research31 Aug 2023
Nature Cancer

Volume: 4, P: 1455-1473
Bladder lesion detection using EfficientNet and hybrid attention transformer through attention transformation

Poonam Sharma
Bhisham Sharma
Julian L. Webber
ResearchOpen Access23 May 2025
Scientific Reports

Volume: 15, P: 1-17
Thermoluminescence dating of sand dunes in Rajasthan, India

A. K. Singhvi
Y. P. Sharma
D. P. Agrawal
Research28 Jan 1982
Nature

Volume: 295, P: 313-315
Phosphorylation-driven epichaperome assembly is a regulator of cellular adaptability and proliferation

Epichaperomes are chaperone assemblies that reorganize protein networks under stress. Here, authors reveal how HSP90 phosphorylation drives epichaperome formation, linking this process to cancer cell behaviors and pluripotent stem cell functions.

Tanaya Roychowdhury
Seth W. McNutt
Feixia Chu
ResearchOpen Access16 Oct 2024
Nature Communications

Volume: 15, P: 1-28
FungAMR: a comprehensive database for investigating fungal mutations associated with antimicrobial resistance

An online, manually curated and continually updating database of fungal antimicrobial resistance mutations provides a starting point for further research in fungal AMR.

Camille Bédard
Alicia Pageau
Christian R. Landry
Research11 Aug 2025
Nature Microbiology

Volume: 10, P: 2338-2352

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