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Showing 1–50 of 1824 results

Advanced filters: Author: D O'Brien Clear advanced filters

Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues

Mellor et al. report that deficiency of GABARAPL1, an ATG8-specific linking protein, impairs diastolic function in diabetic mice. This effect can be reversed by gene delivery of the gene encoding GABARAPL1 in diabetic mice and a human organoid model of type 2 diabetes.

K. M. Mellor
U. Varma
L. M. D. Delbridge
Research29 Sept 2025
Nature Cardiovascular Research

P: 1-14
Coupling CRISPR scanning with targeted chromatin accessibility profiling using a double-stranded DNA deaminase

This paper presents TDAC-seq, a targeted chromatin-accessibility-profiling method using cytidine deaminases and long-read sequencing, to resolve the effects of CRISPR edits on single chromatin fibers.

Heejin Roh
Simon P. Shen
Brian B. Liau
Research11 Sept 2025
Nature Methods

Volume: 22, P: 2083-2093
Thyrotrophin Releasing Factor in Hypophyseal Portal Blood

R. L. W. AVERILL
D. F. SALAMAN
W. CURTIS WORTHINGTON jun.
Research09 Jul 1966
Nature

Volume: 211, P: 144-145
Secondary Clumping Effect in Human Citrated Platelet-Rich Plasma Produced by Adenosine Diphosphate and Adrenaline

D. C. MACMILLAN
Research09 Jul 1966
Nature

Volume: 211, P: 140-144
Lightning-induced relativistic electron precipitation from the inner radiation belt

Microburst are observed in Earth’s outer and inner radiation belts, and in the slot region at typically keV energies. Here, the authors show direct observations of lightning-induced electron precipitation at MeV energies.

Max Feinland
Lauren W. Blum
Mark Looper
ResearchOpen Access08 Oct 2024
Nature Communications

Volume: 15, P: 1-9
Intracrine FFA4 signaling controls lipolysis at lipid droplets

An ‘intracrine’ signaling mechanism is proposed whereby a G-protein-coupled receptor (free fatty acid receptor 4) senses locally released fatty acids on intracellular membranes associated with lipid droplets to efficiently regulate lipolysis in adipocytes.

Shannon L. O’Brien
Emma Tripp
Davide Calebiro
ResearchOpen Access05 Aug 2025
Nature Chemical Biology

P: 1-11
Common feedstocks of late accretion for the terrestrial planets

The impact flux in the inner Solar System just after its formation is studied by looking at the highly siderophile element abundance of Vesta. Results show that leftover planetesimals from the terrestrial planet region have been the major impactor source, indicative of a skewed mass distribution in the primordial inner Solar System.

Meng-Hua Zhu
Alessandro Morbidelli
Kai Wünnemann
Research30 Sept 2021
Nature Astronomy

Volume: 5, P: 1286-1296
Three autosomal dominant corneal dystrophies map to chromosome 5q

Edwin M. Stone
William D. Mathers
Val C. Sheffield
Research01 Jan 1994
Nature Genetics

Volume: 6, P: 47-51
Quantitative Differential Thermal Analysis: Heats and Rates of Solid-Liquid Transitions

D. M. SPEROS
R. L. WOODHOUSE
Research30 Mar 1963
Nature

Volume: 197, P: 1261-1263
Correlation Between Unit Activity and Slow Potential Changes in the Unanaesthetized Cerebral Cortex of the Cat

A. D. J. ROBERTSON
Research20 Nov 1965
Nature

Volume: 208, P: 757-758
An actin-binding protein from Acanthamoeba regulates actin filament polymerization and interactions

Gerhard Isenberg
Ueli Aebi
Thomas D. Pollard
Research04 Dec 1980
Nature

Volume: 288, P: 455-459
Porosity of the Mouse Placenta to Maternal Cells

MAUREEN TUFFREY
N. P. BISHUN
R. D. BARNES
Research15 Mar 1969
Nature

Volume: 221, P: 1029-1030
Walden Inversion and Reaction Mechanism: Walden Inversion in Unimolecular Reactions of Secondary and Tertiary Alkyl Halides

E. D. HUGHES
C. K. INGOLD
D. F. MEIGH
Research21 Oct 1950
Nature

Volume: 166, P: 679-680
Ultrafast acousto-plasmonic control and sensing in complex nanostructures

The nanometre length scale of plasmonic structures leads to vibrational dynamics at high frequencies, which could be exploited for sensitive optical detectors. O'Brien et al. show that they can detect spatial properties of phonon modes in multimodal plasmonic structures, revealing complex nanomechanical dynamics.

Kevin O’Brien
N. D. Lanzillotti-Kimura
Xiang Zhang
Research04 Jun 2014
Nature Communications

Volume: 5, P: 1-6
Geomagnetically Trapped Radiation Produced by a High-Altitude Nuclear Explosion on July 9, 1962

B. J. O'BRIEN
C. D. LAUGHLIN
J. A. VAN ALLEN
Research08 Sept 1962
Nature

Volume: 195, P: 939-943
Self-control as a mediator between caregiver burden and psychological resilience among psychiatric caregivers in Oman

Al Reem Al Marshoudi
Maram Al Aisaiee
Mohammed Al Alawi
ResearchOpen Access09 Oct 2025
Scientific Reports

Volume: 15, P: 1-8
The role of CCR5 and CCR2 polymorphisms in HIV-1 transmission and disease progression

Nelson L. Michael
Leslie G. Louie
Haynes W. Sheppard
Research01 Oct 1997
Nature Medicine

Volume: 3, P: 1160-1162
Action of Schradan in the Cockroach

R. D. O'BRIEN
E. Y. SPENCER
Research05 Jan 1957
Nature

Volume: 179, P: 52-53
Are the Lsh and Ity disease resistance genes at one locus on mouse chromosome 1?

Janet E. Plant
Jenefer M. Blackwell
A. A. Glynn
Research10 Jun 1982
Nature

Volume: 297, P: 510-511
Vitamin B₄ and Adenine

R. D. HEARD
H. W. KINNERSLEY
V. READER
Research29 Apr 1933
Nature

Volume: 131, P: 617-618
Radio Observations of the Quiet Sun at 49 cm

G. SWARUP
V. K. KAPAHI
R. P. SINHA
Research26 Nov 1966
Nature

Volume: 212, P: 910-911
Action of D-1-Alkyl-2-(α-Hydroxybenzyl)-Benzimidazoles on Tissue-Culture Cells Infected with Poliovirus

D. G. O'SULLIVAN
DANICA PANTIC
A. K. WALLIS
Research25 Jan 1964
Nature

Volume: 201, P: 378-379
Fast X-ray transient EP240315A from a Lyman-continuum-leaking galaxy at z ≈ 5

Observations of a fast X-ray transient reveal that it is a gamma-ray-burst explosion from a very distant galaxy that emits light with the wavelength necessary to drive cosmic reionization, the last major phase change in the history of the Universe.

Andrew J. Levan
Peter G. Jonker
Tayyaba Zafar
Research19 Aug 2025
Nature Astronomy

Volume: 9, P: 1375-1386
Membrane Active Drugs and the Aggregation of Human Blood Platelets

D. C. B. MILLS
G. C. K. ROBERTS
Research07 Jan 1967
Nature

Volume: 213, P: 35-38
Genetic heterogeneity in GM1-gangliosidosis

H. GALJAARD
A. HOOGEVEEN
D. ROBINSON
Research01 Sept 1975
Nature

Volume: 257, P: 60-62
Sasanlimab plus BCG in BCG-naive, high-risk non-muscle invasive bladder cancer: the randomized phase 3 CREST trial

As presented at the 2025 ASCO Annual Meeting: in a randomized controlled phase 3 trial evaluating subcutaneous administration of sasanlimab, an anti-PD-1 inhibitor, with Bacillus Calmette–Guérin induction and maintenance treatment, combination treatment significantly improved event-free survival versus standard-of-care therapy.

Neal D. Shore
Thomas B. Powles
Gary D. Steinberg
ResearchOpen Access31 May 2025
Nature Medicine

Volume: 31, P: 2806-2814
Activation of Thionophosphates by Liver Microsomes

R. D. O'BRIEN
Research10 Jan 1959
Nature

Volume: 183, P: 121-122
Somites are a source of nephron progenitors in zebrafish

This study reveals that cells of the zebrafish kidney can originate from the somites, structures traditionally held as precursors to the skeletal muscle, challenging a century-old paradigm and prompting a re-evaluation of kidney organogenesis in vertebrates.

Zhenzhen Peng
Thitinee Vanichapol
Alan J. Davidson
ResearchOpen Access26 Jul 2025
Nature Communications

Volume: 16, P: 1-11
Hydrolysis of Esters by Extracts of Insects

K. A. LORD
C. POTTER
Research10 Oct 1953
Nature

Volume: 172, P: 679-681
Conservation of Conformation in Mono and Poly-nucleotides

STRUTHER ARNOTT
D. W. L. HUKINS
Research29 Nov 1969
Nature

Volume: 224, P: 886-888
Role of fimbrin and villin in determining the interfilament distances of actin bundles

Paul Matsudaira
Eckhard Mandelkow
Klaus Weber
Research20 Jan 1983
Nature

Volume: 301, P: 209-214
Reproductive and genetic consequences of founding isolated lion populations

D. E. Wildt
M. Bush
S. J. O'Brien
Research24 Sept 1987
Nature

Volume: 329, P: 328-331
Binding in Hæmoglobin Azide as Determined by Electron Resonance: Electron Resonance Studies of Hæmoglobin Azide and Hydroxide Derivatives

J. F. GIBSON
D. J. E. INGRAM
Research06 Jul 1957
Nature

Volume: 180, P: 29-30
Circulating tumor DNA analysis guiding adjuvant therapy in stage II colon cancer: 5-year outcomes of the randomized DYNAMIC trial

An updated analysis of the DYNAMIC biomarker-driven trial, including mature survival data at 5 years, supports a ctDNA-guided approach to adjuvant chemotherapy for stage II colon cancer.

Jeanne Tie
Yuxuan Wang
Peter Gibbs
Research07 Mar 2025
Nature Medicine

Volume: 31, P: 1509-1518
Exome analysis links kidney malformations to developmental disorders and reveals causal genes

The authors analyze rare coding variants in 1990 individuals with congenital kidney anomalies, finding diagnostic variants in 14.1% of cases. They identify two new causal genes, ARID3A and NR6A1, along with 38 candidate genes, providing evidence for shared genetics with other developmental disorders.

Hila Milo Rasouly
Sarath Babu Krishna Murthy
Ali G. Gharavi
ResearchOpen Access07 Aug 2025
Nature Communications

Volume: 16, P: 1-16
Kelvin on the Origin of the Earth

D. W. ALLAN
Research28 Apr 1956
Nature

Volume: 177, P: 801-802
Observations of an extreme storm in interplanetary space caused by successive coronal mass ejections

Coronal mass ejections are large expulsions of plasma from the solar corona into space, and are drivers of major space weather effects. Here, the authors report observations of two successive ejections, whose interaction led to extremely enhanced magnetic fields and high solar wind speeds near 1 AU.

Ying D. Liu
Janet G. Luhmann
Antoinette B. Galvin
Research18 Mar 2014
Nature Communications

Volume: 5, P: 1-8
Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex

Ossenkoppele, Coomans and colleagues analyzed the tau PET data of 12,048 individuals from 42 cohorts worldwide. They found that age, amyloid-β status, presence of an APOE ε4 allele and female sex are key contributors to tau PET positivity, which should aid clinical decision-making and trial designs.

Rik Ossenkoppele
Emma M. Coomans
Oskar Hansson
ResearchOpen Access16 Jul 2025
Nature Neuroscience

Volume: 28, P: 1610-1621
Examining the replicability of online experiments selected by a decision market

This study finds that decision markets can be a useful tool for selecting studies for replication. For a sample of 26 online experiments published in PNAS selected by a decision market, the authors find replication rates ranging between 54% and 62%.

Felix Holzmeister
Magnus Johannesson
Anna Dreber
ResearchOpen Access19 Nov 2024
Nature Human Behaviour

Volume: 9, P: 316-330
Detection of BCR-ABL kinase domain mutations in CD34+ cells from newly diagnosed chronic phase CML patients and their association with imatinib resistance

Abid Taj
Muhammad Khalid
Tariq Gill
ResearchOpen Access28 Nov 2011
Nature Precedings

P: 1
Changes in Intracellular Hydrogen Ion Activity in Acute Experimental Salicylate Intoxication

J B Moon
D O'Brien
Research01 Jul 1967
Pediatric Research

Volume: 1, P: 277-286
Maternal and Fœtal Lipids of Sheep

D. R. BODY
F. B. SHORLAND
Research23 May 1964
Nature

Volume: 202, P: 769
Voltage-dependent translocation of the asialoglycoprotein receptor across lipid membranes

Robert Blumenthal
Richard D. Klausner
John N. Weinstein
Research27 Nov 1980
Nature

Volume: 288, P: 333-338
Behaviour in Eggs and Tissue Culture of the Inclusion BlennorrhŒea (LB4) Strain of the Trachoma–Inclusion Conjunctivitis Virus group

N. M. LARIN
J. D. TREHARNE
Research10 Oct 1964
Nature

Volume: 204, P: 166-167
Relationship between Refractive Index and Concentration of Solutions

F. A. GLOVER
J. D. S. GOULDEN
Research21 Dec 1963
Nature

Volume: 200, P: 1165-1166
A fast X-ray transient from a weak relativistic jet associated with a type Ic-BL supernova

The Einstein Probe has discovered a fast X-ray transient, EP240414a, associated with a broad-lined type Ic supernova. Its unusually soft spectrum and weak jet add to the diversity of stellar deaths and suggest a previously unknown Wolf–Rayet star explosion mechanism.

H. Sun
W.-X. Li
H. Zou
Research26 Jun 2025
Nature Astronomy

Volume: 9, P: 1073-1085
Carbonate chemistry of an in-situ free-ocean CO₂ enrichment experiment (antFOCE) in comparison to short term variation in Antarctic coastal waters

J. S. Stark
N. P. Roden
D. Roberts
ResearchOpen Access12 Feb 2018
Scientific Reports

Volume: 8, P: 1-16
WSTF nuclear autophagy regulates chronic but not acute inflammation

During chronic but not acute inflammation, chromatin remodelling is influenced by nuclear autophagy through WSTF interaction with ATG8 in the nucleus, leading to WSTF nuclear export and its subsequent degradation.

Yu Wang
Vinay V. Eapen
Zhixun Dou
Research02 Jul 2025
Nature

Volume: 644, P: 780-789
An Asn > Lys substitution in saposin B involving a conserved amino acidic residue and leading to the loss of the single N-glycosylation site in a patient with metachromatic leukodystrophy and normal arylsulphatase A activity

Stefano Regis
Mirella Filocamo
Rosanna Gatti
Research30 Mar 1999
European Journal of Human Genetics

Volume: 7, P: 125-130
Aspirin, indomethacin, catecholamine and prostaglandin interactions on rat arterioles and rabbit hearts

D. F. HORROBIN
M. S. MANKU
PATRICA A. DAVIES
Research02 Aug 1974
Nature

Volume: 250, P: 425-426

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